IP-10 is Interferon gamma (INF-γ) inducible protein 10. It is a chemokine, and important for recruiting natural killer cells to the myocardium, and for limiting viral duplication in murine (mice/rodent) coxsackievirus infection.
Alternative names[edit | edit source]
IP-10 is also known as:
- C-X-C motif chemokine 10
- IFN-γ inducible protein 10
- Interferon gamma inducible protein 10
- 10 kDa interferon-gamma induced protein
Notable studies[edit | edit source]
- This study found "compelling evidence" of the role of several cytokines/chemokine]]s in the physiological and cognitive pathology in a group of patients with chronic fatigue syndrome, although these patients were selected using the Oxford criteria, which includes many patients with chronic fatigue not caused by ME/CFS.
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- "CXCL10 - C-X-C motif chemokine 10 precursor - Homo sapiens (Human) - CXCL10 gene & protein". www.uniprot.org. Retrieved Jan 24, 2019.
- Loux, Tara J.; Lotze, Michael T.; Zeh, Herbert J. (Jan 1, 2010). Lotze, Michael T.; Thomson, Angus W., eds. "Chapter Fourteen - NK cells as recipients of cytokine signals". San Diego: Academic Press: 189–201. ISBN 9780123704542.
- Lee, James J.; Rosenberg, Helene F., eds. (Jan 1, 2013). "Chapter 6 - Eosinophil Trafficking". Eosinophils in Health and Disease. Boston: Academic Press: 121–166. ISBN 9780123943859.
- McArdle, Anne; Gusnanto, Arief; Earl, Kate; Sakellariou, George; Lawton, Clare; Owens, Daniel; Close, Graeme; Beadsworth, Michael; Dye, Louise (Apr 1, 2017). "The role of IP-10 in Chronic Fatigue Syndrome". The FASEB Journal. 1 (1_supplement): lb789. doi:10.1096/fasebj.31.1_supplement.lb789.
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.