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Hypovitaminosis C is also when in-hospital highly prevalent but almost completely unrecognized. Medical awareness of this potentially important disorder is hindered by the inability of most hospital laboratories to determine plasma Vitamin C concentrations. The availability of a simple, reliable method for analyzing plasma vitamin C could increase opportunities for routine plasma vitamin C analysis in clinical medicine.
This is also described in will give the following symptoms: lassitude, fatigue and irritability.
Evidence[edit | edit source]
The disease of terminal vitamin C deficiency – Scurvy – is first suspected on clinical grounds. The diagnosis is confirmed by documenting a plasma vitamin C concentration < 11.4 μmol/L and observing prompt clinical improvement after appropriate vitamin C provision. Scurvy is rare in the modern world, but hypovitaminosis C (plasma vitamin C concentration < 28.4 μmol/L ) or marginal vitamin C deficiency (plasma vitamin C concentration < 28.4 μmol/L but > 11.4 μmol/L ) is not. Hypovitaminosis C occurs in ~ 10% of the general population , in ~ 30 % of cigarette smokers and ~ 60% of acutely hospitalized patients, in whom it could contribute to fatigue and mood disturbance, immune system dysfunction, impaired wound healing, the complex regional pain syndrome and the complications of cardiovascular disease.
Cited from  : Subclinical Vitamin C Deficiency: Clinical Application. Six of seven volunteers noted mild but distinct fatigue and/or irritability at depletion, without scurvy. Symptoms disappeared within several days of the 30- or 60-mg daily dose. Although fatigue and irritability have myriad causes, vitamin C deficiency without scurvy should be an additional consideration. Since fatigue and irritability are common symptoms and were so easily reversible, physicians should ask patients with these symptoms about vitamin C ingestion from foods or supplements.
Blood test[edit | edit source]
Notable studies[edit | edit source]
- 1996, Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance (Full Text)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Robitaille, Line; Hoffer, L John (Apr 21, 2016), "A simple method for plasma total vitamin C analysis suitable for routine clinical laboratory use", Nutrition Journal, 15 (40)
- Levine, Mark; Conry-Cantilena, Cathy; Wang, Yaohui; Welch, Richard W.; Washko, Louis R.; Dhariwal; Park; Lazarev; Graumlich; King; Cantilena (1996), "Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance", Proc Natl Acad Sci U S A, 93 (8): 3704-9