GETSET trial

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

The GETSET trial (short for Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome) was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with CFS/ME. The protocol was published in June 2016.[1] The results were published in June 2017.[2]

Researchers[edit | edit source]

Lead Author Lucy Clark, Peter White, Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon

Funding[edit | edit source]

The trial was funded in full by the National Institute for Health Research's Research for Patient Benefit programme.[3]

Protocol[edit | edit source]

The protocol of the trial was published in JMIR Research Protocols in June 2016.[1]

Publications[edit | edit source]

The results were published on 22 June 2017 in the Lancet: Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial[4]

Commentary was provided by Daniel Clauw in the Lancet: Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome.[5]

The Science Media Centre provided: Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS).[6]

It was reported in the Telegraph as Exercise can help chronic fatigue syndrome, study shows and other media outlets: Defeating chronic fatigue thanks to guided self-help approach to exercise.[7]

The long term follow-up results were published July 2021 in the Journal of Psychosomatic Research: Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial.[8]

Criticism[edit | edit source]

Dr David Tuller criticized the trial in the blog post Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet. Tuller later also criticized misleading presentation of the long term follow-up results, which presented the results as demonstrating sustained improvement, despite them finding a lack of significant difference between the treated and untreated groups.[9] The paper was subsequently revised in response to this criticism.[10]

Spoonseekerdotcom has criticised the GETSET trial.[11][12][13]

Professor Jonathan Edwards criticised the study for its "incompetent level of science".[14]

The ME Association also criticised the trial in ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function.

Additional criticism has been published by other patients such as Lou Corsius and Cort Johnson.[15][16]

Documents[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 Clark, Lucy V.; McCrone, Paul; Ridge, Damien; Cheshire, Anna; Vergara-Williamson, Mario; Pesola, Francesca; White, PeterD. (June 8, 2016), "Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study", JMIR research protocols, 5 (2): 70, doi:10.2196/resprot.5395, PMC 4917732, PMID 27278762
  2. ↑ Clark, Lucy V.; Pesola, Francesca; Thomas, Janice; Vergara-Williamson, Mario; Beynon, Michelle; White, PeterD. (June 22, 2017), "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial", The Lancet, doi:10.1016/S0140-6736(16)32589-2
  3. ↑ "ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME". isrctn.com. Retrieved January 26, 2020.
  4. ↑ Clark, Lucy V.; Pesola, Francesca; Thomas, Janice M.; Vergara-Williamson, Mario; Beynon, Michelle; White, PeterD. (July 22, 2017). "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial". The Lancet. 390 (10092): 363–373. doi:10.1016/S0140-6736(16)32589-2. ISSN 0140-6736. PMID 28648402.
  5. ↑ Clauw, Daniel J (July 2017). "Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome". The Lancet. 390 (10092): 335–336. doi:10.1016/S0140-6736(17)30577-9.
  6. ↑ "expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) | Science Media Centre". Retrieved May 8, 2020.
  7. ↑ "Defeating chronic fatigue thanks to guided self-help approach to exercise". Emergency Live. Retrieved May 8, 2020.
  8. ↑ Clark, Lucy V.; McCrone, Paul; Pesola, Francesca; =Vergara-Williamson, Mario; White, Peter D. (July 1, 2021). "Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial". Journal of Psychosomatic Research. 146: 110484. doi:10.1016/j.jpsychores.2021.110484. ISSN 0022-3999.
  9. ↑ "Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise–but Declares Success Anyway". www.virology.ws. Retrieved November 8, 2022.
  10. ↑ Clark, Lucy V.; McCrone, Paul; Pesola, Francesca; =Vergara-Williamson, Mario; White, Peter D. (September 1, 2021). "Corrigendum to "Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial" [Journal of Psychosomatic Research 146 (2021) 110484]". Journal of Psychosomatic Research. 148: 110542. doi:10.1016/j.jpsychores.2021.110542. ISSN 0022-3999.
  11. ↑ Spoonseeker, Author (May 23, 2016). "A Few Notes on GETSET". spoonseekerdotcom. Retrieved January 26, 2020.
  12. ↑ Spoonseeker, Author (June 29, 2017). "Do GET Yourself". spoonseekerdotcom. Retrieved January 26, 2020.
  13. ↑ Spoonseeker, Author (July 3, 2017). "Spotlight on GETSET Julie". spoonseekerdotcom. Retrieved January 26, 2020.
  14. ↑ "Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet". Phoenix Rising ME / CFS Forums. Retrieved January 26, 2020.
  15. ↑ Corsius, Lou (June 23, 2017). "Yet another publication with misleading conclusions from PACE-land". it's about ME (in Nederlands). Retrieved January 26, 2020.
  16. ↑ Johnson, Cort (June 26, 2017). "On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)". Health Rising. Retrieved January 26, 2020.
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