Ribose

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Ribose is a carbohydrate with the formula C5H10O5, that exists in two forms: D-ribose, which occurs in nature and L-ribose, which is the mirror image of D-ribose and does not occur in nature.[1]

D-ribose is a building block used by the cells in one of the chemical pathways that makes the energy molecule, ATP.[2]

D-ribose comes in powder form, tastes sweet, and can used as a sugar substitute in drinks or on cereal.

Use in ME/CFS and FM[edit | edit source]

It is used as a supplement for help boost muscle energy, such as for athletes and people with ME/CFS, Fibromyalgia, and coronary artery disease.[3] The theory is that if one supplies the body with the precursors to ATP, then it will be easier for the body to make ATP.[2]

Sources[edit | edit source]

Supplemental d-ribose is manufactured from corn, so is to be avoided by those with corn allergies or insensitivities.[2]

Evidence[edit | edit source]

A small study of 41 patients by Jacob Teitelbaum resulted in: "Approximately 66% of patients experienced significant improvement while on D-ribose [at a dose of 5 g, three times a day], with an average increase in energy on the VAS [visual analog scale categories: energy; sleep; mental clarity; and pain intensity] of 45% and an average improvement in overall well-being of 30% (p < 0.0001)." The study authors concluded that "D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome".[4]

Risks[edit | edit source]

Oral D-Ribose intake is linked to memory loss, anxiety, and Aβ-like deposits associated with Alzheimer’s in mice.[5][6][7]

Learn more[edit | edit source]

See also[edit | edit source]

Muscle fatigability

References[edit | edit source]

  1. Wikipedia - Ribose
  2. 2.02.12.2 Doctor Myhill - D-ribose
  3. WebMD - Vitamins and Supplements - Ribose
  4. Teitelbaum, Jacob E.; Johnson, Clarence; St Cyr, John (November 2006), "The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study", Journal of Alternative and Complementary Medicine (New York, N.Y.), 12 (9): 857–862, doi:10.1089/acm.2006.12.857, ISSN 1075-5535, PMID 17109576 
  5. "D-Ribose linked to Memory Loss, Anxiety, & Aβ-like deposits associated with Alzheimer's in Mice". 
  6. Wu, Beibei; Wei, Yan; Wang, Yujing; Su, Tao; Zhou, Lei; Liu, Ying; He, Rongqiao (Oct 7, 2015). "Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice". Oncotarget. 6 (33): 34128–34142. ISSN 1949-2553. PMC 4741441Freely accessible. PMID 26452037. 
  7. Han, C.; Lu, Y.; Wei, Y.; Wu, B.; Liu, Y.; He, R. (Mar 2014). "D -ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation". Cell Death & Disease. 5 (3): e1117–e1117. doi:10.1038/cddis.2014.89. ISSN 2041-4889. 

chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.