Calcitonin gene-related peptide

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Calcitonin gene-related peptide or CGRP is a neurosensory peptide that has a key role in pain and is a key sensory neurotransmitter involved in immune function, and is mainly expressed in the central and peripheral sensory nerves.[1][2] CGRP is part of the calcitonin gene family.[3][4] CGRP triggers migraines in people who experience migraines but not in others.[5]

Known isoforms of CGRP are αCGRP (alpha CGRP) and βCGRP (beta CGRP).[1]

Purpose[edit | edit source]

The nervous system and immune system release CGRP when transient receptor potential vanilloid 1 (TRPV1) is activated.[1] CGRP regulates inflammation in the skin, has a key role in neurogenic inflammation and has protective effects on the heart.[6]

αCGRP[edit | edit source]

αCGRP or CGRP-I is a vasodilator, appears to act as an immunomodulator, and may affect the inflammatory cascade to a pathological threat .[1][6]

βCGRP[edit | edit source]

βCGRP or CGRP-II.[1][6]

ME/CFS[edit | edit source]

αCGRP is the main isotype in sensory neurons in the dorsal root ganglion.[1]

Evidence[edit | edit source]

CGRP antagonists have been found to be effective in the treatment and prevention of migraines.

News and interviews[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.01.11.21.31.41.5 https://www.frontiersin.org/articles/10.3389/fnins.2014.00023/full
  2. Abudool, A.A.; Kodji, X.; Brain, S.D. (2017). "Calcitonin Gene-Related Peptide (CGRP)". Encyclopedia of Endocrine Diseases. 4. New York: Elsevier. pp. 425–435. doi:10.1016/b978-0-12-801238-3.95757-x. ISBN 978-0-12-812200-6.
  3. Granstein, Richard D.; Wagner, John A.; Stohl, Lori L.; Ding, Wanhong (March 2015). "Calcitonin Gene-Related Peptide: Key Regulator of Cutaneous Immunity". Acta physiologica (Oxford, England). 213 (3): 586–594. doi:10.1111/apha.12442. ISSN 1748-1708. PMC 4308419. PMID 25534428.
  4. Russell, F. A.; King, R.; Smillie, S.-J.; Kodji, X.; Brain, S. D. (October 2014). "Calcitonin Gene-Related Peptide: Physiology and Pathophysiology". Physiological Reviews. 94 (4): 1099–1142. doi:10.1152/physrev.00034.2013. ISSN 0031-9333. PMC 4187032. PMID 25287861.
  5. https://europepmc.org/article/MED/20820195
  6. 6.06.16.2 https://www.sciencedirect.com/science/article/pii/S2666354621001642

β β / Β. Greek letter beta (a symbol used in science), equivalent to "b".

immunomodulator An immunomodulator is a substance that affects the functioning of the immune system

antagonist A chemical that reduces or helps block the activity of another chemical in the body. For example, most antihistamines are H1 antagonists because they block the H1 histamine receptor, which helps relieve allergy symptoms. The opposite of an agonist.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.