Calcitonin gene-related peptide

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Calcitonin gene-related peptide or CGRP is a neurosensory peptide that has a key role in pain and is a key sensory neurotransmitter involved in immune function, and is mainly expressed in the central and peripheral sensory nerves.[1][2] CGRP is part of the calcitonin gene family.[3][4] CGRP triggers migraines in people who experience migraines but not in others.[5]

Known isoforms of CGRP are αCGRP (alpha CGRP) and βCGRP (beta CGRP).[1]

Purpose[edit | edit source]

The nervous system and immune system release CGRP when transient receptor potential vanilloid receptor 1 (TRPV1) is activated.[1] CGRP regulates inflammation in the skin, has a key role in neurogenic inflammation and has protective effects on the heart.[6]

αCGRP[edit | edit source]

αCGRP or CGRP-I is a vasodilator, appears to act as an immunomodulator, and may affect the inflammatory cascade to a pathological threat .[1][6]

βCGRP[edit | edit source]

βCGRP or CGRP-II.[1][6]

ME/CFS[edit | edit source]

αCGRP is the main isotype in sensory neurons in the dorsal root ganglion.[1]

Evidence[edit | edit source]

CGRP antagonists have been found to be effective in the treatment and prevention of migraines.

News and interviews[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 1.3 1.4 1.5
  2. Abudool, A.A.; Kodji, X.; Brain, S.D. (2017). "Calcitonin Gene-Related Peptide (CGRP)". Encyclopedia of Endocrine Diseases. 4. New York: Elsevier. pp. 425–435. doi:10.1016/b978-0-12-801238-3.95757-x. ISBN 978-0-12-812200-6.
  3. Granstein, Richard D.; Wagner, John A.; Stohl, Lori L.; Ding, Wanhong (March 2015). "Calcitonin Gene-Related Peptide: Key Regulator of Cutaneous Immunity". Acta physiologica (Oxford, England). 213 (3): 586–594. doi:10.1111/apha.12442. ISSN 1748-1708. PMC 4308419. PMID 25534428.
  4. Russell, F.A.; King, R.; Smillie, S.-J.; Kodji, X.; Brain, S.D. (October 2014). "Calcitonin Gene-Related Peptide: Physiology and Pathophysiology". Physiological Reviews. 94 (4): 1099–1142. doi:10.1152/physrev.00034.2013. ISSN 0031-9333. PMC 4187032. PMID 25287861.
  6. 6.0 6.1 6.2