Interferon gamma inducible protein 10

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(Redirected from CXCL10)

IP-10 is Interferon gamma (INF-γ) inducible protein 10, and is also known as C-X-C Motif Chemokine Ligand 10 or CXCL10.[1] IP-10 is a chemokine, and important for recruiting natural killer cells to the myocardium, and for limiting viral duplication in murine (mice/rodent) coxsackievirus infection.[2]

Alternative names[edit | edit source]

IP-10 is also known as:

Function[edit | edit source]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

  • 2017 - The Role of IP-10 in Chronic Fatigue Syndrome[4]
This study found "compelling evidence" of the role of several cytokines/chemokines in the physiological and cognitive pathology in a group of patients with chronic fatigue syndrome, although these patients were selected using the Oxford criteria, which includes many patients with chronic fatigue not caused by ME/CFS.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 "CXCL10 - C-X-C motif chemokine 10 precursor - Homo sapiens (Human) - CXCL10 gene & protein". Retrieved January 24, 2019.
  2. 2.0 2.1 Loux, Tara J.; Lotze, Michael T.; Zeh, Herbert J. (January 1, 2010). Lotze, Michael T.; Thomson, Angus W. (eds.). Chapter Fourteen - NK cells as recipients of cytokine signals. San Diego: Academic Press. pp. 189–201. ISBN 9780123704542.
  3. Lee, James J.; Rosenberg, Helene F., eds. (January 1, 2013). Chapter 6 - Eosinophil Trafficking. Eosinophils in Health and Disease. Boston: Academic Press. pp. 121–166. ISBN 9780123943859.
  4. McArdle, Anne; Gusnanto, Arief; Earl, Kate; Sakellariou, George; Lawton, Clare; Owens, Daniel; Close, Graeme; Beadsworth, Michael; Dye, Louise (April 1, 2017). "The role of IP-10 in Chronic Fatigue Syndrome". The FASEB Journal. 1 (1 supplement): lb789. doi:10.1096/fasebj.31.1_supplement.lb789.