Brigitte Huber

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Source:Tufts University

Brigitte Huber, PhD, is a Professor of Integrative Physiology & Pathobiology, at the Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts.[1] She has studied the presence of retrovirus HERV K-18 as a potential biomarker for those who develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) after a case of infectious mononucleosis.[2] HERV-K18 is one of many endogenous human retroviruses in the normal human genome. It can be activated in a variety of ways and affect the outcome of Epstein-Barr virus infection and influence autoimmune disease.[3]Dr. Huber's research has shown that there are more HERV K-18 alleles in post-mononucleosis ME/CFS patients than in controls.[4]

In 2011, Dr. Huber and her lab associates were one of the groups who were unable to duplicate Dr. Judy Mikovits's finding of the presence of XMRV in ME/CFS patients.[5]In 2013, she and her lab associates were unable to show reactivation of human herpesvirus 6 (HHV-6) or human herpesvirus 7 (HHV-7) in chronic fatigue syndrome.[6]

Education[edit | edit source]

  • BA, Biology, University of Zurich
  • MSc, Pharmacology, University of Basel
  • PhD, Immunogenetics, University of London
  • Postdoctoral Training, Harvard Medical School

Talks and interviews[edit | edit source]

Studies[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. http://sackler.tufts.edu/Faculty-and-Research/Faculty-Profiles/Brigitte-Huber-Profile
  2. http://www.investinme.org/IIMEC5.shtml
  3. http://sackler.tufts.edu/Faculty-and-Research/Faculty-Research-Pages/Brigitte-Huber
  4. http://www.investinme.org/IIMEC5.shtml
  5. Oakes B1, Qiu X, Levine S, Hackett J Jr, Huber BT. (2011). Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays. Advances in Virology, 2011:854540. doi: 10.1155/2011/854540. Epub 2011 Jul 27. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22312356
  6. Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. (2013). Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. Clinical Infectious Disease,56 (10):1394-400. doi: 10.1093/cid/cit086. Epub 2013 Feb 13. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23408682
  7. Sutkowski N1, Conrad B, Thorley-Lawson DA, Huber BT. (2001). Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity, 15 (4):579-89
  8. Oakes B, Qiu X, Levine S, Hackett J Jr, Huber BT. (2011). Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays. Advances in Virology,2011:854540. doi: 10.1155/2011/854540
  9. Oakes B, Hoagland-Henefield M, Komaroff AL, Erickson JL, Huber BT. (2013). Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients. Clinical Infectious Disease, 56 (10):1394-400. doi: 10.1093/cid/cit086

endogenous - Growing or originating from within an organism.

genome - an organism’s complete set of DNA, including all of its genes

antibody - Antibodies or immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.