Valyl-tRNA synthetase 2, mitochondrial: Difference between revisions
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Notjusttired (talk | contribs) m (Text replacement - "|first5=" to " | first5 = ") |
Notjusttired (talk | contribs) m (Text replacement - "|last=" to " | last =") |
||
| Line 1: | Line 1: | ||
{{stub}} | {{stub}} | ||
'''Valyl-tRNA synthetase 2, mitochondrial''' or '''Valine--TRNA Ligase, Mitochondrial''' or '''VARS2''' or '''VARS2L''' or '''VARSL''' or '''DKFZP434L1435''' or '''G7a''' or '''KIAA1885''' is a protein encoded by the VARS2 gene. VARS2 encodes mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of [[valine]] to tRNA(Val) for mitochondrial translation.<ref name="proteinatlas" /><ref name="genecards">{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=VARS2|title=VARS2 Gene|last= | first = |authorlink= | date = |website=Gene Cards|archive-url=|archive-date=|url-status=|access-date=2022-01-16}}</ref> | '''Valyl-tRNA synthetase 2, mitochondrial''' or '''Valine--TRNA Ligase, Mitochondrial''' or '''VARS2''' or '''VARS2L''' or '''VARSL''' or '''DKFZP434L1435''' or '''G7a''' or '''KIAA1885''' is a protein encoded by the VARS2 gene. VARS2 encodes mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of [[valine]] to tRNA(Val) for mitochondrial translation.<ref name="proteinatlas" /><ref name="genecards">{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=VARS2|title=VARS2 Gene | last = | first = |authorlink= | date = |website=Gene Cards|archive-url=|archive-date=|url-status=|access-date=2022-01-16}}</ref> | ||
==Function== | ==Function== | ||
| Line 7: | Line 7: | ||
* neurodevelopmental disorder With microcephaly (unusually small skull will be visible at birth) | * neurodevelopmental disorder With microcephaly (unusually small skull will be visible at birth) | ||
* seizures | * seizures | ||
* cortical atrophy (a wasting in part of the brain matter)<ref name="proteinatlas">{{Cite web|url=https://www.proteinatlas.org/ENSG00000137411-VARS2|title=VARS2 protein expression summary|last= | first = |authorlink= | date = |website=The Human Protein Atlas|archive-url=|archive-date=|url-status=|access-date=2022-01-16}}</ref><ref name="genecards" /> | * cortical atrophy (a wasting in part of the brain matter)<ref name="proteinatlas">{{Cite web|url=https://www.proteinatlas.org/ENSG00000137411-VARS2|title=VARS2 protein expression summary | last = | first = |authorlink= | date = |website=The Human Protein Atlas|archive-url=|archive-date=|url-status=|access-date=2022-01-16}}</ref><ref name="genecards" /> | ||
==ME/CFS== | ==ME/CFS== | ||
| Line 13: | Line 13: | ||
==Notable studies== | ==Notable studies== | ||
* 2019, Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study<ref name="Nathanson2019">{{Cite journal|last=Nathanson | first = Lubov | authorlink = Lubov Nathanson | authorlink2 = Travis Craddock | last2 = Craddock | first2 = Travis J.A. | last3 = Klimas | first3=Nancy G.|author-link3=Nancy Klimas | authorlink4 = | last4 = Gemayel | first4 = Kristina | last5 = Del Alamo | first5 = Ana | authorlink5 = Ana Del Alamo | authorlink6 = | last6 = Hilton | first6=Kelly | last7 = Jaundoo | first7 = Rajeev | authorlink7 = | last8 = Perez | first8 = Melanie | authorlink8 = | date = 2019 | title=Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study|url=https://www.frontiersin.org/articles/10.3389/fped.2019.00206/full|journal=Frontiers in Pediatrics|language=English|volume=7|issue=|pages=206|doi=10.3389/fped.2019.00206|issn=2296-2360}}</ref> [https://doi.org/10.3389/fped.2019.00206 (Full text)] | * 2019, Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study<ref name="Nathanson2019">{{Cite journal | last =Nathanson | first = Lubov | authorlink = Lubov Nathanson | authorlink2 = Travis Craddock | last2 = Craddock | first2 = Travis J.A. | last3 = Klimas | first3=Nancy G.|author-link3=Nancy Klimas | authorlink4 = | last4 = Gemayel | first4 = Kristina | last5 = Del Alamo | first5 = Ana | authorlink5 = Ana Del Alamo | authorlink6 = | last6 = Hilton | first6=Kelly | last7 = Jaundoo | first7 = Rajeev | authorlink7 = | last8 = Perez | first8 = Melanie | authorlink8 = | date = 2019 | title=Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study|url=https://www.frontiersin.org/articles/10.3389/fped.2019.00206/full|journal=Frontiers in Pediatrics|language=English|volume=7|issue=|pages=206|doi=10.3389/fped.2019.00206|issn=2296-2360}}</ref> [https://doi.org/10.3389/fped.2019.00206 (Full text)] | ||
==See also== | ==See also== | ||
Revision as of 00:19, March 4, 2023
 | This article is a stub. |
Valyl-tRNA synthetase 2, mitochondrial or Valine--TRNA Ligase, Mitochondrial or VARS2 or VARS2L or VARSL or DKFZP434L1435 or G7a or KIAA1885 is a protein encoded by the VARS2 gene. VARS2 encodes mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation.[1][2]
Function[edit | edit source]
VARS2 gene mutations cause combined oxidative phosphorylation deficiency-20, and are associated with:
- early-onset mitochondrial encephalopathies
- neurodevelopmental disorder With microcephaly (unusually small skull will be visible at birth)
- seizures
- cortical atrophy (a wasting in part of the brain matter)[1][2]
ME/CFS[edit | edit source]
The ME/CFS Gene Study is still collecting data, but the pilot study publication by Perez et al. (2019) found that VARS2 was one of the ten relatively common genes or gene variants that were both significantly more common in people with ME/CFS, and likely to be harmful.[3]
Notable studies[edit | edit source]
- 2019, Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study[3] (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
- VARS2 - The Human Protein Atlas
- VARS2 Gene - Gene cards
References[edit | edit source]
- ↑ 1.0 1.1 "VARS2 protein expression summary". The Human Protein Atlas. Retrieved January 16, 2022.
- ↑ 2.0 2.1 "VARS2 Gene". Gene Cards. Retrieved January 16, 2022.
- ↑ 3.0 3.1 Nathanson, Lubov; Craddock, Travis J.A.; Klimas, Nancy G.; Gemayel, Kristina; Del Alamo, Ana; Hilton, Kelly; Jaundoo, Rajeev; Perez, Melanie (2019). "Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study". Frontiers in Pediatrics. 7: 206. doi:10.3389/fped.2019.00206. ISSN 2296-2360.
