Ekua Brenu
Ekua Weba Brenu, PhD, is a post-doctorate researcher at the School of Medical Science, Griffith University, Griffith Health Institute, and a Senior Research Fellow at the National Centre for Neuroimmunology and Emerging Diseases, Gold Coast, Queensland, Australia.[1]
Awards[edit | edit source]
- 2011, Junior Investigator Award to encourage young CFS/FM researchers in recognition of their work awarded by IACFSME.[2]
Diagnostic biomarker[edit | edit source]
In 2015, Griffith University filed for a patent for a biological marker (Patent Publication number WO2016023077 A1) for the diagnosis and management of ME and CFS. Sonya Marshall-Gradisnik and Ekua Brenu are listed as the inventors. The patent application states: "The present invention resides broadly in the use of at least one miRNA as a biological marker for identifying or diagnosing a subject having CFS and/or ME." Very simply stated, microRNA (miRNA) are molecules involved in gene expression. They are different from mRNA which stands for messenger RNA.[3] In 2016, Griffith University's Professor Donald Staines and Professor Sonya Marshall-Gradisnik announced that they have been awarded a $4-million grant to be administered during the next five years that will enable them to continue research into developing a diagnostic test for ME/CFS.[4]
Notable studies in ME/CFS[edit | edit source]
- 2011, Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[5] (Full Text)
- 2012, Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis[6] (Full Text)
- 2012, Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[7] (Abstract)
- 2012, The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[8] (Full Text)
- 2013, The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings[9] (Abstract)
- 2014, The Role of Adaptive and Innate Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[10] (Full Text)
- 2014, Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[11] (Full Text)
- 2014, Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)[12] (Full Text)
- 2015, A Comparison of Cytokine Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Patients[13] (Full Text)
- 2015, Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients[14] (Full Text)
- 2015, Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)[15] (Full Text)
- 2015, Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients[16] (Full Text)
- 2015, Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients[17] (Full Text)
- 2015, Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis[18] (Full Text)
- 2016, Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison.[19] (Full Text)
- 2016, Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis[20] (Abstract)
- 2016, A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis[21] (Full Text)
Talks and interviews[edit | edit source]
- 2013, The 2nd International Symposium for Chronic Fatique Syndrome/Myalgic Encephalomyelitis Presented: "Immune dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"[22]
Online presence[edit | edit source]
Learn more[edit | edit source]
- Ekua Brenu page at Griffith University
- Ekua Brenu receives Junior Investigator Research Award for CFS/ME
See also[edit | edit source]
References[edit | edit source]
- ↑ https://www.griffith.edu.au/health/national-centre-neuroimmunology-emerging-diseases/our-team
- ↑ "IACFS/ME Awardees". IACFS/ME. Retrieved April 23, 2020.
- ↑ https://www.google.co.uk/patents/WO2016023077A1?cl=en&dq=sonya+marshall-gradisnik
- ↑ http://www.goldcoastbulletin.com.au/lifestyle/gold-coast-team-getting-closer-to-discovering-test-for-chronic-fatigue-syndrom/news-story/1627b3fcc41c53efac927200a53cc756
- ↑ 1first 2 first 1 first 3 first 2, "Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"
- ↑ 1first 6 first 1 first 7 first 6, "Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis"
- ↑ 1first 2 first 1 first 3 first 2, "Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis."
- ↑ Brenu; van Driel, Mieke L; Staines, Donald R; Kreijkamp-Kaspers, Sanne; Hardcastle, Sharni L; Marshall-Gradisnik, Sonya M (2012), "The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis" (PDF), International Journal of Clinical Medicine, 3 (6): 544-551, doi:10.4236/ijcm.2012.36098 Text "first 1" ignored (help)
- ↑ Johnston, S. C.; Brenu; Staines, D. R.; Marshall-Gradisnik (2013), "The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings", Fatigue: Biomedicine, Health & Behavior, 2 (1): 28-39, doi:10.1080/21641846.2013.860779 Text "first 2" ignored (help); Text "first 4" ignored (help)
- ↑ 1first 2 first 1 first 3 first 2, "The Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis"
- ↑ 2first 3 first 2 first 6 first 3, "Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"
- ↑ 4first 5 first 4 first 7 first 5, "Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)"
- ↑ 1first 2 first 1 first 4 first 2, "A Comparison of Cytokine Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Patients"
- ↑ 1first 8 first 1 first 9 first 8, "Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients"
- ↑ 1first 3 first 1 first 8 first 3, "Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)"
- ↑ Marshall-Gradisnik, Sonya M.; Smith; Brenu, Ekua W.; Nilius; Ramos, Sandra B.; Staines, Donald R. (2015), "Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients", Immunology and Immunogenetics Insights, 7 (2015): 1-6, doi:10.4137/III.S25147 Text "first 2" ignored (help); Text "first 4" ignored (help)
- ↑ 4first 5 first 4 first 6 first 5, "Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients"
- ↑ 1first 2 first 1 first 3 first 2, "Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis"
- ↑ 1first 2 first 1 first 3 first 2, "Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison"
- ↑ 2first 3 first 2 first 4 first 3, "Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis"
- ↑ Brenu, EW; Broadley, S; Nguyen, T; Johnston, S; Ramos, S; Staines, D; Marshall-Gradisnik, S (January 4, 2016), "A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis" (PDF), Journal of Immunology Research: 9064529, doi:10.1155/2016/9064529
- ↑ https://www.griffith.edu.au/__data/assets/pdf_file/0009/566118/CFS-Symposium-2013-Program.pdf