Wiskott-Aldrich Syndrome Protein Family Member 3
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WASF3 or WAVE3 or Wiskott-Aldrich Syndrome Protein Family Member 3 is a protein-encoding gene which has been implicated in chronic fatigue including the fatigue and exertion intolerance found in ME/CFS and Long COVID.[1]
Function[edit | edit source]
WASF3 possibly regulates brain cytokines involved in the fatigue through the p38 MAPK regulatory pathway.[2]
ME/CFS[edit | edit source]
In 2023, a Centers for Disease Control study by Wang et al. reported that over-expression of WASF3 may contribute to exercise intolerance in patients with ME/CFS.[3]
A new, unlicensed and unapproved drug called salubrinal is being investigated as a potential treatment for ME/CFS and long-COVID because it appears to block or suppress WASF3 production.[1]
Notable studies[edit | edit source]
- 2025, Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID[1] - (Abstract)
- 2023, WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome[3] - (Abstract)
- 2011, Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data[4] - (Full text)
News and articles[edit | edit source]
- A protein that disrupts cells’ energy centers may be a culprit in chronic fatigue syndrome - Science
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 1.2 Warrayat, Aseel; Ali, Ayah; Waked, Joulin; Tocci, Darcy; Speth, Robert C. (May 2025). "Assessment of the therapeutic potential of salubrinal for ME/CFS and long-COVID". Trends in Molecular Medicine. 31 (5): 466–478. doi:10.1016/j.molmed.2024.10.001. ISSN 1471-4914.
- ↑ "WASF3 Gene - WASP Family Member 3". Genecards. Retrieved August 15, 2023.
- ↑ 3.0 3.1 Wang, Ping-Yuan; Ma, Jin; Kim, Young-Chae; Son, Annie Y.; Syed, Abu Mohammad; Liu, Chengyu; Mori, Mateus P.; Huffstutler, Rebecca D.; Stolinski, JoEllyn L.; Talagala, S. Lalith; Kang, Ju-Gyeong (August 22, 2023). "WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome". Proceedings of the National Academy of Sciences. 120 (34): e2302738120. doi:10.1073/pnas.2302738120. ISSN 0027-8424.
- ↑ Pihur, Vasyl; Datta, Somnath; Datta, Susmita (April 22, 2011). "Meta analysis of Chronic Fatigue Syndrome through integration of clinical, gene expression, SNP and proteomic data". Bioinformation. 6 (3): 120–124. ISSN 0973-2063. PMC 3089886. PMID 21584188.
