Vance Spence

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Vance A. Spence, Ph.D., was a Principal Clinical Scientist responsible for vascular services and research. In 1997, he returned from an early retirement due to contracting myalgic encephalomyelitis (ME)[1] to become an Honorary Senior Research Fellow in the Department of Medicine at the University of Dundee, Scotland, with the objective of stimulating research into the cause of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS).[2] He is especially interested in the role of inflammation, oxidative stress, and acetylcholine in these illnesses.

Dr Spence helped found and serves as Chairman of ME Research UK, a research group.[3] Additionally, he helped found MERGE, the ME biomedical research charity and serves as Scientific Advisor for the 25 Percent ME Group, a patient group for the severe ME patient.[1]

Talks and interviews[edit | edit source]

  • 01 May 2007, Speaker at Day 1 of the 2nd Invest in ME International ME Conference; talk title - Biomedical Research into ME/CFS: where does it go from here[4] - (Video)
  • 02 May 2007, Speaker at Day 2 of the 2nd Invest in ME International ME Conference; talk title - Biomedical Research into ME/CFS: where does it go from here[4] - (Video)
  • 2007, Speaker at the Eighth International IACFSME Conference Agenda on "Inflammation and Arterial Stiffness in Patients with Chronic Fatigue Syndrome"[5]
  • 2014, Speaker at the ME Research UK Stormont Parliament meeting, ‘ME in Northern Ireland: practice and research priorities’; talk title - “The science of ME/CFS: What do we know?”[6]

Notable studies[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.01.1 "Patrons, Trustees, Advisers". 25% M.E. Group. Retrieved Feb 19, 2020. 
  2. "Invest in ME Research - IIMEC2". www.investinme.org. Retrieved Feb 19, 2020. 
  3. "Meet the team | ME Research UK". Retrieved Feb 19, 2020. 
  4. 4.04.1 "Invest in ME Research - IIMEC2". www.investinme.org. Retrieved Feb 19, 2020. 
  5. "Home". www.iacfsme.org. Retrieved Feb 19, 2020. 
  6. "Meeting at Stormont Parliament | ME Research UK". Retrieved Feb 19, 2020. 
  7. Khan, Faisel; Kennedy, Gwen; Spence, Vance A.; Newton, David J.; Belch, Jill J. F. (2004), "Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure", Clinical Science, 106 (2): 183-189, doi:10.1042/CS20030246 
  8. Spence, VA; Khan, F; Kennedy, G; Abbot, NC; Belch, JJ (2004), "Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome", Prostaglandins, leukotrienes, and essential fatty acids, 70 (4): 403-7, doi:10.1016/j.plefa.2003.12.016 
  9. Kennedy, Gwen; Spence, Vance A.; McLaren, Margaret; Hill, Alexander; Underwood, Christine; Belch, Jill J. F. (2005), "Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms", Free Radical Biology and Medicine, 39 (5): 584–589, doi:10.1016/j.freeradbiomed.2005.04.020 
  10. Spence, Vance A.; Kennedy, Gwen; Belch, Jill J. F.; Hill, Alexander; Khan, Faisel (2008), "Low-grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome", Clinical Science, 114 (8): 561-566, doi:10.1042/CS20070274 

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

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