Tubulin polymerization promoting protein
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Tubulin Polymerization Promoting Protein or TPPP is a protein-encoding gene that may be associated with ME/CFS.[1] The TPPP protein is an antibody expressed in the brain.[1][2]
Function[edit | edit source]
ME/CFS[edit | edit source]
The largest genetic study of ME/CFS patients was published by Hajdarevic et al. in 2022; and analysed data from over 2,500 patients from the UK Biobank, Norway and Denmark, reported they "did not find any ME/CFS risk loci displaying genome-wide significance". The study did find that the Tubulin Polymerization Promoting Protein (TPPP) region may be implicated in ME/CFS.[1]
Notable studies[edit | edit source]
- 2022, Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci[1] - (Full text)
See also[edit | edit source]
Learn more[edit | edit source]
- TPPP Gene | TPPP Protein | TPPP Antibody - GeneCards
References[edit | edit source]
- ↑ 1.0 1.1 1.2 1.3 Hajdarevic, Riad; Lande, Asgeir; Mehlsen, Jesper; Rydland, Anne; Sosa, Daisy D.; Strand, Elin B.; Mella, Olav; Pociot, Flemming; Fluge, Øystein; Lie, Benedicte A.; Viken, Marte K. (May 1, 2022). "Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci". Brain, Behavior, and Immunity. 102: 362–369. doi:10.1016/j.bbi.2022.03.010. ISSN 0889-1591.
- ↑ "TPPP Gene | TPPP Protein | TPPP Antibody". GeneCards. Retrieved March 29, 2022.
