Tryptase alpha/beta 1

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Tryptase alpha/beta 1 or TPSAB1 is a protein-encoding gene for tryptase.[1]

Function[edit | edit source]

Hereditary alpha tryptasemia syndrome[edit | edit source]

Extra copies of the TPSAB1 gene is known as familial hypertryptasemia (FHT) or hereditary alpha tryptasemia (H⍺T or HAT) and is one of several possible causes for increased tryptase production.[2] HAT is common and often does not cause illness.[2]

Hereditary alpha tryptasemia syndrome (HATS) is a recently discovered multi-systemic illness involving an increased number of TPSAB1 genes with a cluster of symptoms similar to those found in MCAS.

Other symptoms and diseases[edit | edit source]

The TPSAB1 has also been implicated in pruritus, medically unexplained (functional) gastrointestinal symptoms and in.[3][2]

ME/CFS[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Tryptase alpha/beta 1 Gene". Gene cards. Retrieved April 3, 2022.
  2. 2.02.12.2 Lyons, Jonathan J. (August 1, 2018). "Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features". Immunology and Allergy Clinics of North America. Mastocytosis. 38 (3): 483–495. doi:10.1016/j.iac.2018.04.003. ISSN 0889-8561. PMC 6411063. PMID 30007465.
  3. "Hereditary Alpha Tryptasemia Syndrome FAQ". National Institute of Allergy and Infectious Diseases. October 17, 2016.

β β / Β. Greek letter beta (a symbol used in science), equivalent to "b".

mastocytosis A type of mast cell disease in which chronic symptoms are related to overproduction or over-accumulation of mast cells. Not to be confused with Mast Cell Activation Syndrome (MCAS), where there are normal numbers of mast cells, but abnormal activity.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.