Tryptase alpha/beta 1
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Tryptase alpha/beta 1 or TPSAB1 is a protein-encoding gene for tryptase.[1]
Function[edit | edit source]
Hereditary alpha tryptasemia syndrome[edit | edit source]
Extra copies of the TPSAB1 gene is known as familial hypertryptasemia (FHT) or hereditary alpha tryptasemia (H⍺T or HAT) and is one of several possible causes for increased tryptase production.[2] HAT is common and often does not cause illness.[2]
Hereditary alpha tryptasemia syndrome (HATS) is a recently discovered multi-systemic illness involving an increased number of TPSAB1 genes with a cluster of symptoms similar to those found in MCAS.
Other symptoms and diseases[edit | edit source]
The TPSAB1 has also been implicated in pruritus, medically unexplained (functional) gastrointestinal symptoms and in.[3][2]
ME/CFS[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
- TPSAB1 Gene - Gene cards
- Hereditary Alpha Tryptasemia Syndrome FAQ - National Institute of Allergy and Infectious Diseases
References[edit | edit source]
- ↑ "Tryptase alpha/beta 1 Gene". Gene cards. Retrieved April 3, 2022.
- ↑ 2.0 2.1 2.2 Lyons, Jonathan J. (August 1, 2018). "Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features". Immunology and Allergy Clinics of North America. Mastocytosis. 38 (3): 483–495. doi:10.1016/j.iac.2018.04.003. ISSN 0889-8561. PMC 6411063. PMID 30007465.
- ↑ "Hereditary Alpha Tryptasemia Syndrome FAQ". National Institute of Allergy and Infectious Diseases. October 17, 2016.
