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A tricyclic antidepressant is a type of antidepressant named for its three-ringed chemical structure. Tricyclic antidepressants can be an effective treatment for depression but are less commonly used now that alternatives with fewer side effects exist. However, they remain a good option if those treatments are not effective in a given case.
Approved tricyclic antidepressants[edit | edit source]
- Desipramine (Norpramin)
- Imipramine (Tofranil)
- Nortriptyline (Pamelor)
- Protriptyline (Vivactil)
- Trimipramine (Surmontil)
Use in ME[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- "Tricyclic antidepressants (TCAs)". Mayo Clinic. Retrieved Jan 9, 2019.
Adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.