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Rotigotine

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Rotigotine is a dopamine agonist used for Parkinson's disease and restless leg syndrome (RLS) which is available only as a slow-release transdermal patch applied to the skin.[1][2] Rotigotine is also sold under the brand name Neupro.[1][3] Rotigotine is in the same class of drugs as ropinirole and pramipexole.[4]

Theory[edit | edit source]

Evidence[edit | edit source]

No clinicial trials have yet been carried out of rotigotine for patients with ME/CFS.

A single study of rotigotine for fibromyalgia had high dropout rates for both the drug and placebo, but did not appear to show a significant improvement in pain or other fibromyalgia symptoms at doses of 4mg or 8mg.[4][5]

There is inconsistent evidence of the effect of rotigotine on fatigue in Parkinson's disease.[6][7]

Clinicians[edit | edit source]

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]


References[edit | edit source]

  1. ↑ Jump up to: 1.0 1.1 "Rotigotine: Indications, Side Effects, Warnings". Drugs.com. Retrieved February 21, 2022.
  2. ↑ "Rotigotine Transdermal Advanced Patient Information". Drugs.com. Retrieved February 21, 2022.
  3. ↑ "Pramipexole: MedlinePlus Drug Information". medlineplus.gov. Retrieved February 21, 2022.
  4. ↑ Jump up to: 4.0 4.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066139/
  5. ↑ https://clinicaltrials.gov/ct2/show/results/NCT00464737
  6. ↑ https://jamanetwork.com/journals/jamaneurology/article-abstract/785048
  7. ↑ https://n.neurology.org/content/78/1_Supplement/P06.088.short

A chemical that binds to the receptor and stimulates it's function, e.g., morphine is an opioid agonist that binds to the opioid receptor, reducing pain. The opposite of an antagonist.[1][2]

agonist A chemical that binds to the receptor and stimulates it's function, e.g., morphine is an opioid agonist that binds to the opioid receptor, reducing pain. The opposite of an antagonist.

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