Proton pump inhibitor

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Proton pump inhibitors or PPIs are a class of drugs that reduce levels of stomach acid.[1]

Proton pump inhibitors may be used to treat symptoms of Gastroesophageal Reflux (GERD).

Warning: long term use of PPIs is considered a risk factor for the development of SIBO[2][3] (small intestinal bacterial overgrowth), which has symptoms like fatigue and brain fog that are quite similar to conditions Chronic fatigue syndrome.

Theory[edit | edit source]

Evidence[edit | edit source]

Clinicians[edit | edit source]

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

List of proton pump inhibitors[edit | edit source]

Proton pump inhibitors include:

Systemic mastocytosis[edit | edit source]

Proton pump inhibitors for systematic mastocytosis (which is not the same as mast cell activation disorder) include:

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 "List of Proton Pump Inhibitors + Uses, Side Effects". Retrieved February 16, 2021.
  2. LO, WAI–KIT; CHAN, Walter W. (2013). "Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis". CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (11): 483–490.
  3. Su, Tingting; Lai, Sanchuan; Lee, Allen; He, Xingkang; Chen, Shujie (January 2018). "Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth". Journal of Gastroenterology. 53 (1): 27–36. doi:10.1007/s00535-017-1371-9. ISSN 1435-5922. PMID 28770351.
  4. "Medications for Systemic Mastocytosis". Retrieved February 18, 2021.