Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

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Peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor or PPIF is protein involved in reactive oxygen species stress response (ROS stress response).[1]

ME/CFS[edit | edit source]

A small study by Sweetman et al. (2020) found that PPIF expression was decreased in patients with ME/CFS compared to healthy controls.[1]

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References[edit | edit source]

  1. ↑ 1.0 1.1 Sweetman, Eiren; Kleffmann, Torsten; Edgar, Christina; de Lange, Michel; Vallings, Rosamund; Tate, Warren (September 24, 2020). "A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction". Journal of Translational Medicine. 18 (1): 365. doi:10.1186/s12967-020-02533-3. ISSN 1479-5876. PMC 7512220.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

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