Nora Chapman

Source:University of Nebraska

Nora M. Chapman, Ph.D., is a Professor in the department of Pathology and Microbiology, at the College of Medicine, University of Nebraska. Her interests are in virology and molecular biology and is part of the University's Enterovirus Research Group. Dr. Chapman and her associates at the University of Nebraska are working to collabrate Dr. John Chia's work on enteroviruses being present in gut biopsies of patients with ME/CFS. She serves on the Board of Directors of the Enterovirus Foundation.

In a landmark 2005 paper, Prof Chapman discovered the mechanism by which a normal lytic enterovirus can get transformed into an aberrant non-cytolytic virus capable of producing persistent low-level infections. The mechanism of transformation involves mutations that the virus acquires during the acute infection in the host: see non-cytolytic enterovirus. This has importance for ME/CFS, which has long been associated with persistent non-cytolytic enteroviral infections of the muscle, brain and stomach tissues.

Education

• B.A. (Highest Honors), University of California, Santa Cruz, 1975
• Ph.D., Harvard University, Cambridge, MA, 1981

Talks and interviews

• 2008: International Symposium on Viruses In CFS and Post-Viral Fatigue: How does a lytic enterovirus infection persist and cause chronic disease?.
• 2009: Human Enteroviruses and Chronic Infectious Disease. Steven Tracy and Nora M. Chapman. Journal of IiME, Vol 3, Issue 1, pages 23-31. Also available as pdf (pages 23-31). 
• 2010: Prof Nora M. Chapman, Invest in ME International ME Conference, London 2010: Persistent Enteroviral Infections.
• 2012: Replication Defective Enterovirus Infections: Implications for Type I Diabetes. Slides from a presentation at the 2012 Annual Meeting of the Network for Pancreatic Organ Donors with Diabetes.
• 2013: Human Enterovirus Persistence: Potential for Exacerbation of Myocarditis. International Academy of Cardiology: 18th World Congress on Heart Disease, 2013 Vancouver, Canada.

Book chapter

• 2008, Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy. In: Tracy S., Oberste M.S., Drescher K.M. (eds) Group B Coxsackieviruses. Current Topics in Microbiology and Immunology, vol 323. Springer, Berlin, Heidelberg (Preview)

Notable studies

• 2002, Toward Testing the Hypothesis that Group B Coxsackieviruses (CVB) Trigger Insulin-Dependent Diabetes: Inoculating Nonobese Diabetic Mice with CVB Markedly Lowers Diabetes Incidence (Full Text)
• 2022, Persistent Enterovirus Infection: Little Deletions, Long Infections.

See also

• Coxsackievirus
• Non-cytolytic enterovirus

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

See myalgic encephalomyelitis.

See chronic fatigue syndrome.

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)