Nora Chapman
Nora M. Chapman, Ph.D., is a Professor in the department of Pathology and Microbiology, at the College of Medicine, University of Nebraska. Her interests are in virology and molecular biology and is part of the University's Enterovirus Research Group.[1] Dr. Chapman and her associates at the University of Nebraska are working to collabrate Dr. John Chia's work on enteroviruses being present in gut biopsies of patients with ME/CFS.[2] She serves on the Board of Directors of the Enterovirus Foundation.[3]
In a landmark 2005 paper,[4] Prof Chapman discovered the mechanism by which a normal lytic enterovirus can get transformed into an aberrant non-cytolytic virus capable of producing persistent low-level infections. The mechanism of transformation involves mutations that the virus acquires during the acute infection in the host: see non-cytolytic enterovirus. This has importance for ME/CFS, which has long been associated with persistent non-cytolytic enteroviral infections of the muscle, brain and stomach tissues.
Education[edit | edit source]
- B.A. (Highest Honors), University of California, Santa Cruz, 1975
- Ph.D., Harvard University, Cambridge, MA, 1981
Talks and interviews[edit | edit source]
- 2008: International Symposium on Viruses In CFS and Post-Viral Fatigue: How does a lytic enterovirus infection persist and cause chronic disease?.
- 2009: Human Enteroviruses and Chronic Infectious Disease. Steven Tracy and Nora M. Chapman. Journal of IiME, Vol 3, Issue 1, pages 23-31. Also available as pdf (pages 23-31).
- 2010: Prof Nora M. Chapman, Invest in ME International ME Conference, London 2010: Persistent Enteroviral Infections.
- 2012: Replication Defective Enterovirus Infections: Implications for Type I Diabetes. Slides from a presentation at the 2012 Annual Meeting of the Network for Pancreatic Organ Donors with Diabetes.
- 2013: Human Enterovirus Persistence: Potential for Exacerbation of Myocarditis. International Academy of Cardiology: 18th World Congress on Heart Disease, 2013 Vancouver, Canada.
Book chapter[edit | edit source]
- 2008, Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy. In: Tracy S., Oberste M.S., Drescher K.M. (eds) Group B Coxsackieviruses. Current Topics in Microbiology and Immunology, vol 323. Springer, Berlin, Heidelberg[5] (Preview)
Notable studies[edit | edit source]
- 2002, Toward Testing the Hypothesis that Group B Coxsackieviruses (CVB) Trigger Insulin-Dependent Diabetes: Inoculating Nonobese Diabetic Mice with CVB Markedly Lowers Diabetes Incidence[6] (Full Text)
- 2022, Persistent Enterovirus Infection: Little Deletions, Long Infections.[7]
See also[edit | edit source]
References[edit | edit source]
- ↑ http://www.unmc.edu/pathology/faculty/bios/chapman.html
- ↑ Invest in ME Research. "Invest in ME Research - IIMEC5 International ME Conference 2010". Invest in ME Research. Retrieved August 8, 2018.
- ↑ "Our Community". Enterovirus Foundation. Retrieved August 8, 2018.
- ↑ Kim, K.-S.; Tracy, S.; Tapprich, W.; Bailey, J.; Lee, C.-K.; Kim, K.; Barry, W.H.; Chapman, N.M. (June 2005). "5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA". Journal of Virology. 79 (11): 7024–7041. doi:10.1128/JVI.79.11.7024-7041.2005. ISSN 0022-538X. PMC 1112132. PMID 15890942.
- ↑ Chapman, N.M.; Kim, K. -S. (2008). "Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy". Current Topics in Microbiology and Immunologyvolume=vol 323. Berlin, Heidelberg: Springer. pp. 275–292. doi:10.1007/978-3-540-75546-3_13. ISBN 9783540755456.
- ↑ Tracy, S.; Drescher, K.M.; Chapman, N.M.; Kim, K.-S.; Carson, S. D.; Pirruccello, S.; Lane, P.H.; Romero, J.R.; Leser, J.S. (December 2002). "Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence". Journal of Virology. 76 (23): 12097–12111. doi:10.1128/JVI.76.23.12097-12111.2002. ISSN 0022-538X. PMID 12414951.
- ↑ Chapman, Nora M. (May 12, 2022). "Persistent Enterovirus Infection: Little Deletions, Long Infections". Vaccines. 10 (5): 770. doi:10.3390/vaccines10050770. ISSN 2076-393X. PMC 9143164. PMID 35632526.
