Theory[edit | edit source]
Molnupiravir was developed specifically to target the Venezuelan equine encephalitis virus (VEEV) but proved effective in early trials against COVID-19 caused by the SARS-CoV-2 virus. Molnupiravir targets the virus by introducing copy errors as it replicates. It breaks down to n-hydroxycytidine (NHC) in the body, and is then metabolised to NHC-TP.
Evidence[edit | edit source]
There is no evidence yet of the use of molnupiravir in patients with ME/CFS.
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Side effects in adults taking molnupiravir for COVID-19 for the recommended 5 days included diarrhea, nausea, dizziness, and headaches which were either mild or moderate, but this was based on a trial of less than 400 people. Based on drug chemistry, interactions with other drugs are not expected.
Costs and availability[edit | edit source]
Molnupiravir is not yet FDA-approved, although approval is likely in 2022. The European Medicines Agency is conducting a rolling review of molnupiravir for COVID-19 and if had been approved by the UK's Medicines and Healthcare products Regulatory Agency. Molnupiravir is taken orally.
Articles and news[edit | edit source]
- Sep 2021, A Daily Pill to treat Covid could be just Months Away Scientists Say - WebMD
Notable studies[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Mahase, Elisabeth (October 4, 2021). "Covid-19: Molnupiravir reduces risk of hospital admission or death by 50% in patients at risk, MSD reports". BMJ. 375: n2422. doi:10.1136/bmj.n2422. ISSN 1756-1833. PMID 34607801.
- "Molnupiravir". DrugBank. Retrieved October 26, 2021.
- "Molnupiravir FDA Approval Status". Drugs.com. Retrieved October 26, 2021.
- "First oral antiviral for COVID-19, Lagevrio (molnupiravir), approved by MHRA". gov.uk. Retrieved November 7, 2021.
- Malek, Rory J.; Bill, Colin A.; Vines, Charlotte M. (December 1, 2021). "Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19". Biomedicine & Pharmacotherapy. 144: 112276. doi:10.1016/j.biopha.2021.112276. ISSN 0753-3322.
- "Lagevrio 200 mg hard capsules - Summary of Product Characteristics (SmPC)". Electronic Medicines Compendium. Retrieved November 7, 2021.
- "Covid-19: EMA starts rolling review of molnupiravir". European Medicines Agency. 2021.
- "A Pill to Treat COVID Could Be Just Months Away". WebMD. Retrieved October 26, 2021.
adverse reaction Any unintended or unwanted response to a treatment, whether in a clinical trial or licensed treatment. May be minor or serious.