Matrix metalloproteinase

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Matrix metalloproteinases (MMPs) are a group of enzymes that in concert are responsible for the degradation of most extracellular matrix proteins including collagen, gelatin, and elastin.

Types[edit | edit source]

Pharmacology[edit | edit source]

Potential MMP inhibitors[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 De Paiva, Cintia S.; Corrales, Rosa M.; Villarreal, Arturo L.; Farley, William J.; Li, De-Quan; Stern, Michael E.; Pflugfelder, Stephen C. (September 1, 2006). "Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye". Experimental Eye Research. 83 (3): 526–535. doi:10.1016/j.exer.2006.02.004. ISSN 0014-4835.
  2. ↑ Roach, D. M; Fitridge, R. A; Laws, P. E; Millard, S. H; Varelias, A; Cowled, P. A (March 1, 2002). "Up-regulation of MMP-2 and MMP-9 Leads to Degradation of Type IV Collagen During Skeletal Muscle Reperfusion Injury; Protection by the MMP Inhibitor, Doxycycline". European Journal of Vascular and Endovascular Surgery. 23 (3): 260–269. doi:10.1053/ejvs.2002.1598. ISSN 1078-5884.
  3. ↑ Niedzwiecki, A.; Rath, M.; Kalinovsky, T.; Monterrey, J.C.; Roomi, M.W. (March 1, 2010). "In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer cell lines by cytokines, inducers and inhibitors". Oncology Reports. 23 (3): 605–614. doi:10.3892/or_00000675. ISSN 1021-335X.
  4. ↑ Choi, Dong-Hoon; Moon, Ik-Sang; Choi, Bong-Kyu; Paik, Jeong-Won; Kim, Yoon-Sik; Choi, Seong-Ho; Kim, Chong-Kwan (2004). "Effects of sub-antimicrobial dose doxycycline therapy on crevicular fluid MMP-8, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis". Journal of Periodontal Research. 39 (1): 20–26. doi:10.1111/j.1600-0765.2004.00696.x. ISSN 1600-0765.
  5. ↑ Li, De-Quan; Lokeshwar, Balakrishna L; Solomon, Abraham; Monroy, Dagoberto; Ji, Zhonghua; Pflugfelder, Stephen C (October 1, 2001). "Regulation of MMP-9 Production by Human Corneal Epithelial Cells". Experimental Eye Research. 73 (4): 449–459. doi:10.1006/exer.2001.1054. ISSN 0014-4835.
  6. ↑ Brown David L.; Desai Kavita K.; Vakili Babak A.; Nouneh Chadi; Lee Hsi-Ming; Golub Lorne M. (April 1, 2004). "Clinical and Biochemical Results of the Metalloproteinase Inhibition with Subantimicrobial Doses of Doxycycline to Prevent Acute Coronary Syndromes (MIDAS) Pilot Trial". Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (4): 733–738. doi:10.1161/01.ATV.0000121571.78696.dc.
  7. ↑ Górska, Renata; Nędzi-Góra, Małgorzata (December 1, 2006). "The effects of the initial treatment phase and of adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in the saliva and peripheral blood of patients with chronic periodontitis". Archivum Immunologiae et Therapiae Experimentalis. 54 (6): 419–426. doi:10.1007/s00005-006-0047-6. ISSN 1661-4917.

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

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