From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Lymphotoxin-alpha or LTA or Tumor necrosis factor beta or TNF-beta gene encodes a cytokine that is produced by Th1 cells, CD8+ T cells, natural killer (NK) cells, B cells, and macrophages.[1][2]

Alternative names for lymphotoxin-alpha include:

  • LT-Alpha
  • LT
  • Tumor Necrosis Factor Ligand Superfamily Member 1
  • TNFB
  • TNFSF1
  • Tumor Necrosis Factor Ligand 1E
  • TNF Superfamily, Member 1
  • TNLG1E[2]

Function[edit | edit source]

The protein encoded by LTA is involved in many inflammatory, immunostimulatory, and antiviral responses.[2]

LTA gene variants have been linked to susceptibility to leprosy type 4, myocardial infarction (heart attacks), non-Hodgkin's lymphoma, and psoriatic arthritis.[2]

ME/CFS[edit | edit source]

Notable studies[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Calmon-Hamaty, Flavia; Combe, Bernard; Hahne, Michael; Morel, Jacques (2011). "Lymphotoxin α revisited: general features and implications in rheumatoid arthritis". Arthritis Research & Therapy. 13 (4): 232. doi:10.1186/ar3376. ISSN 1478-6354. PMC 3239340. PMID 21861866.
  2. 2.0 2.1 2.2 2.3 "LT-Alpha Gene card". Gene cards. Retrieved March 18, 2022.