Excessive irritability

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Presentation[edit | edit source]

Prevalence[edit | edit source]

  • Katrina Berne reports a prevalence of 70-90% for mood swings, excessive irritability, and overreaction in people with chronic fatigue syndrome.[1]

Symptom recognition[edit | edit source]

  • In the Holmes criteria, excessive irritability is an optional criteria for diagnosis, under the section Minor Symptom Criteria - Neuropsychologic Complaints.[2]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

Potential treatments[edit | edit source]

Severe irritability is a common symptom in autism, and the main treatment for this is atypical anti-psychotic drugs such as amisulpride (Solian), risperidone (Risperdal) or aripiprazole (Abilify).[3] Very low dose amisulpride has also been shown to reduce the fatigue and bodily symptoms of ME/CFS[4]. N-acetyl-cysteine can help the irritability in autism, but the research showed this is not quite as effective as atypical anti-psychotics.[5]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Berne, Katrina (Dec 1, 1995). Running on Empty: The Complete Guide to Chronic Fatigue Syndrome (CFIDS) (2nd ed.). Hunter House. p. 60. ISBN 978-0897931915. 
  2. The 1988 Holmes Definition for CFS
  3. Posey, David J.; Stigler, Kimberly A.; Erickson, Craig A.; McDougle, Christopher J. (Jan 2, 2008). "Antipsychotics in the treatment of autism". The Journal of Clinical Investigation. 118 (1): 6–14. doi:10.1172/JCI32483. ISSN 0021-9738. PMC 2171144Freely accessible. PMID 18172517. 
  4. Pardini, Matteo; Guida, Silvia; Primavera, Alberto; Krueger, Frank; Cocito, Leonardo; Gialloreti, Leonardo Emberti (Mar 2011). "Amisulpride vs. fluoxetine treatment of chronic fatigue syndrome: a pilot study". European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology. 21 (3): 282–286. doi:10.1016/j.euroneuro.2010.10.008. ISSN 1873-7862. PMID 21112746. 
  5. Hardan, Antonio Y.; Fung, Lawrence K.; Libove, Robin A.; Obukhanych, Tetyana V.; Nair, Surekha; Herzenberg, Leonore A.; Frazier, Thomas W.; Tirouvanziam, Rabindra (Jun 2012). "A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism". Biological Psychiatry. 71 (11): 956–961. doi:10.1016/j.biopsych.2012.01.014. ISSN 0006-3223. PMC 4914359Freely accessible. PMID 22342106. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.