Discoidin Domain Receptor Tyrosine Kinase 1
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Discoidin Domain Receptor Tyrosine Kinase 1 or DDR1 is a tyrosine kinase receptor.[1]
Alternative names[edit | edit source]
- RTK6
- CD167
- CD167 Antigen-Like Family Member A 3 4
- Protein-Tyrosine Kinase RTK-6[1]
Function[edit | edit source]
DDR1 is a tyrosine kinase receptor for collagen.[2]
Diseases[edit | edit source]
Altered DDR function may be associated with:
- Cancer, particularly familial breast cancer and cervix small cell carcinoma
- Lymphangioleiomyomatosis (LAM)
- Idiopathic pulmonary fibrosis
- Meninges sarcoma
- Tissue fibrosis[1]
Drugs[edit | edit source]
Established DDR1 inhibitors, including:
- imatinib, a kinase inhibitor
- dasatinib
- nilotinib[3]
Drugs targetting DDR1 include:
- fostamatinib, a kinase inhibitor (investigational)
- pralsetinib (investigational)
- ATP (investigational)
- DDR1-IN-1[1]
ME/CFS[edit | edit source]
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 1.2 1.3 "Discoidin Domain Receptor Tyrosine Kinase 1". Gene cards. Retrieved November 9, 2021.
- ↑ Guerrot, Dominique; Kerroch, Monique; Placier, Sandrine; Vandermeersch, Sophie; Trivin, Claire; Mael-Ainin, Mouna; Chatziantoniou, Christos; Dussaule, Jean-Claude (July 2011). "Discoidin Domain Receptor 1 Is a Major Mediator of Inflammation and Fibrosis in Obstructive Nephropathy". The American Journal of Pathology. 179 (1): 83–91. doi:10.1016/j.ajpath.2011.03.023. ISSN 0002-9440. PMC 3123843. PMID 21640971.
- ↑ Kothiwale, Sandeepkumar; Borza, Corina M.; Lowe, Will; Pozzi, Ambra; Meiler, Jens (February 2015). "Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery". Drug discovery today. 20 (2): 255–261. doi:10.1016/j.drudis.2014.09.025. ISSN 1359-6446. PMC 4336622. PMID 25284748.
