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BLLF3

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

BLLF3 is a gene that encodes the protein dUTPase or deoxyuridine triphosphatase, which is an early Epstein-Barr virus (EBV) protein.[1]

Function[edit | edit source]

ME/CFS[edit | edit source]

Ariza (2021) published a hypothesis showing a role for BLLF3 in the immune dysfunction found in ME/CFS.

Notable[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

  • Outside articles: e.g. WebMD, Merck Manual

References[edit | edit source]

  1. ↑ 1.0 1.1 Ariza, Maria Eugenia (January 29, 2021). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!". Biomolecules. 11 (2): 185. doi:10.3390/biom11020185. ISSN 2218-273X. PMC 7912523. PMID 33572802.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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