BLLF3

BLLF3 is a gene that encodes the protein dUTPase or deoxyuridine triphosphatase, which is an early Epstein-Barr virus (EBV) protein.

ME/CFS

Ariza (2021) published a hypothesis showing a role for BLLF3 in the immune dysfunction found in ME/CFS.

Notable

• 2021, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!</ref> - (Full text)

See also

• Epstein-Barr virus

Learn more

• Outside articles: e.g. WebMD, Merck Manual

See myalgic encephalomyelitis.

See chronic fatigue syndrome.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.