Brain-derived neurotrophic factor
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Brain-derived neurotrophic factor or BDNF is a protein in the neurotrophic family.[1] The name BDNF is also used to refer to the related gene that expresses BDNF.[1]
Function[edit | edit source]
ME/CFS[edit | edit source]
Notable studies[edit | edit source]
- 2015, Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome[2] - (Abstract)
- 2015, Exercise and caffeine improve sustained attention following fatigue independent of fitness status[3] - (Full text)
- 2015, Brain-derived neurotrophic factor (BDNF) as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?[4] - (Full text)
- 2020, DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia[5] - (Abstract)
See also[edit | edit source]
- Central sensitization
- Allodynia (pain on touch)
Learn more[edit | edit source]
- Epigenetic modification of BDNF and HDAC in pain and post-exertional malaise - ME Research UK
- Epigenetics of the BDNF gene and its relevance for pain: an exploratory study - ME Research UK
- Brain-derived neurotrophic factor (BDNF) as a driving force behind central sensitization pain: a new therapeutic target? - Jo Nijs (2015), Pain in Motion
References[edit | edit source]
- ↑ 1.0 1.1 Binder, Devin K.; Scharfman, Helen E. (September 2004). "Brain-derived Neurotrophic Factor". Growth factors (Chur, Switzerland). 22 (3): 123–131. doi:10.1080/08977190410001723308. ISSN 0897-7194. PMC 2504526. PMID 15518235.
- ↑ Patrick, David M.; Miller, Ruth R.; Steiner, Theodore; Gardy, Jennifer L.; Parker, Shoshana M.; Tang, Patrick (April 3, 2015). "Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 3 (2): 122–125. doi:10.1080/21641846.2015.1024004. ISSN 2164-1846.
- ↑ Kumar, Namrita; Wheaton, Lewis A.; Snow, Teresa K.; Millard-Stafford, Melinda (April 3, 2015). "Exercise and caffeine improve sustained attention following fatigue independent of fitness status". Fatigue: Biomedicine, Health & Behavior. 3 (2): 104–121. doi:10.1080/21641846.2015.1027553. ISSN 2164-1846.
- ↑ Nijs, Jo; Meeus, Mira; Versijpt, Jan; Moens, Maarten; Bos, Inge; Knaepen, Kristel; Meeusen, Romain (April 2015). "Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?". Expert Opinion on Therapeutic Targets. 19 (4): 565–576. doi:10.1517/14728222.2014.994506. ISSN 1744-7631. PMID 25519921.
- ↑ Polli, Andrea; Ghosh, Manosij; Bakusic, Jelena; Ickmans, Kelly; Monteyne, Dora; Velkeniers, Brigitte; Bekaert, Bram; Godderis, Lode; Nijs, Jo (November 2020). "DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia". Arthritis & Rheumatology (Hoboken, N.J.). 72 (11): 1936–1944. doi:10.1002/art.41405. ISSN 2326-5205. PMID 32562379.
