Talk:Diagnostic biomarker

This page is getting very large.

I think it would be better to re-arrange it into subheadings by the area of body or type of test, with alphabetic subheadings underneath, or move tests to change to a category with separate pages for each test, perhaps with discategories like Brain imaging, Blood tests. Tests could turn fit in multiple categories of needed.

• Blood tests
  • Cytokines
  • B-calls
  • Plasma neuropeptide Y

• Brain imaging

• Physiological tests
  • Hand grip strength
  • Two-day cardiopulmonary exercise testing

• Saliva tests

tests so far are -

Blood tests

Activin B

ATP Profiles Test (Mitochondrial energy production blockage)

Buspirone challenge test

CellTrend diagnostic test

Cytokine expression

EBV-encoded DNA polymerase and EBV-encoded dUTPase

Electrical Impedance

Extracellular Vesicles

Immunosignatures

Metabolomics

MicroRNA (miRNA)

Natural killer cell function

Phenylalanine measured via Raman microspectroscopy

Plasma neuropeptide Y

Ratio of active:inactive PKR

TCA and urea cycles

Brain imaging

DTI and MRI tests

ECG

Short QT interval

Cerebrospinal fluid

Orosomucoid

Proteome in cerebrospinal fluid

Physiological tests

Hand grip strength

Two-day cardiopulmonary exercise testing

Saliva tests

Saliva proteins ACON and ATPB

Urine tests

Allantoin

Combination of methods

Blood and fecal matter / Gut microbiome

Blood and muscle nerves (electrical) /Combination of M-wave, TBars, and CD2

Others

notjusttired (talk) 13:28, 13 November 2018 (EST)

Reliability of the markers is missing -- 95.90.247.229 19:23, May 15, 2021 (UTC)

The page provides a list of "biomarkers", but does not mention which of those studies have been replicated / falsified and to what extend. This is necessary to judge the expressiveness of that particular method.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

plasma The liquid part of blood, lymph, or milk after removing any suspended material. Most of the time, "plasma" simply refers to blood, after all the blood cells have been removed. If you also remove the clotting factors, then the plasma is referred to as "serum".

physiological Concerning living organisms, such as cells or the human body.  Physio logical (as in physio) is not to be confused with psych ological (emotional stress).

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

extracellular vesicle An extracellular vesicle (sometimes abbreviated EV) is a piece of a cell that has broken off and formed a separate membrane-bound vesicle. A membrane-bound vesicle is like a bubble, or like a mini-cell, in that it has a membrane surrounding some liquid. An extracellular vesicle may also contain some parts of the cell from which the extracellular vesicle arose. There are currently two types of extracellular vesicles: "exosomes" and "microvesicles". An "exosome" is an extracellular vesicle that began inside the cell as an intracellular vesicle known as an "endosome". A "microvesicle" is an extracellular vesicle that begins at the cell surface, and pinches off the cell's own membrane to form a separate vesicle. (Learn more: journals.physiology.org)

metabolomics The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.