Vitamin D receptor

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The Vitamin D receptor (VDR) is a cell receptor that turns on the expression of certain pathways when activated by Vitamin D. VDR is also the term used to refer to the protein-encoding gene for the vitamin D receptor.[1]

Function[edit | edit source]

Vitamin D Receptor and mitochondria function. Source: Int. J. Mol. Sci. 2018(19): 1672.[2]

Vitamin D has a wide range of effects in the human body, and mutations in VDR and other genes related to vitamin D methylation have been linked to many different diseases including autoimmune and infectious diseases, several cancers, type 2 diabetes, obesity, vitamin D-resistant rickets and others.[3][4]

VDR has recently been found to be essential for metabolism.[2] VDR may be required for the normal development of natural killer T cells that react to cells expressing CD1d, as in cells infected by certain viruses.[5]

ME/CFS[edit | edit source]

An Epstein-Barr virus protein EBNA-3 has an affinity for VDR and may actually block the activation of VDR-dependent genes by Vitamin D.[6]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "VDR - Vitamin D Receptor". Gene cards. Retrieved June 12, 2024.
  2. 2.0 2.1 Ricca, Chiara; Aillon, Alessia; Bergandi, Loredana; Alotto, Daniela; Castagnoli, Carlotta; Silvagno, Francesca (June 5, 2018). "Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health". International Journal of Molecular Sciences. 19 (6): 1672. doi:10.3390/ijms19061672. ISSN 1422-0067. PMC 6032156. PMID 29874855.
  3. Gasperini, Beatrice; Falvino, Angela; Piccirilli, Eleonora; Tarantino, Umberto; Botta, Annalisa; Visconti, Virginia Veronica (December 20, 2023). "Methylation of the Vitamin D Receptor Gene in Human Disorders". International Journal of Molecular Sciences. 25 (1): 107. doi:10.3390/ijms25010107. ISSN 1422-0067. PMC 10779104. PMID 38203278.
  4. Campbell, Moray J.; Trump, Donald L. (December 2017). "Vitamin D Receptor Signaling and Cancer". Endocrinology and metabolism clinics of North America. 46 (4): 1009–1038. doi:10.1016/j.ecl.2017.07.007. ISSN 0889-8529. PMC 7092369. PMID 29080633.
  5. Yu, Sanhong; Cantorna, Margherita T. (April 1, 2008). "The vitamin D receptor is required for iNKT cell development". Proceedings of the National Academy of Sciences of the United States of America. 105 (13): 5207–5212. doi:10.1073/pnas.0711558105. ISSN 0027-8424. PMC 2278204. PMID 18364394.
  6. Yenamandra, Surya Pavan; Hellman, Ulf; Kempkes, Bettina; Darekar, Suhas Deoram; Petermann, Sabine; Sculley, Tom; Klein, George; Kashuba, Elena (December 2010). "Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes". Cellular and molecular life sciences: CMLS. 67 (24): 4249–4256. doi:10.1007/s00018-010-0441-4. ISSN 1420-9071. PMC 11115686. PMID 20593215.