Pentadecapeptide BPC 157

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Pentadecapeptide BPC 157, a fragment of gastric juice peptide BPC,[1] is an experimental compound used in research for its potential applications in wound healing, collagen repair and angiogenesis.[2]

BPC 157 improved wound healing in rats with muscle crush injury and contusions, and quadricep transection,[3][4] even in the presence of corticosteroids (which impair wound healing).[4] It has also demonstrated efficacy in experimental ulcer models[5] and models of traumatic nerve injury.[6]

References[edit | edit source]

  1. Sikiric, Predrag; Seiwerth, Sven; Grabarevic, Zeljko; Petek, Marijan; Rucman, Rudolf; Turkovic, Branko; Rotkvic, Ivo; Jagic, Vjekoslav; Duvnjak, Marko (Jan 1, 1994). "The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides". Life Sciences. 54 (5): PL63–PL68. doi:10.1016/0024-3205(94)00796-9. ISSN 0024-3205. 
  2. Seiwerth, Sven; Brcic, Luka; Batelja Vuletic, Lovorka; Kolenc, Danijela; Aralica, Gorana; Misic, Marija; Zenko, Anita; Drmic, Domagoj; Rucman, Rudolf (2014). "BPC 157 and Blood Vessels". www.ingentaconnect.com. Retrieved Jun 24, 2019. 
  3. Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka (2006). "Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157". Journal of Orthopaedic Research. 24 (5): 1109–1117. doi:10.1002/jor.20089. ISSN 1554-527X. 
  4. 4.0 4.1 Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka (2006). "Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157". Journal of Orthopaedic Research. 24 (5): 1109–1117. doi:10.1002/jor.20089. ISSN 1554-527X. 
  5. Sikiric, Predrag; Seiwerth, Sven; Grabarevic, Zeljko; Petek, Marijan; Rucman, Rudolf; Turkovic, Branko; Rotkvic, Ivo; Jagic, Vjekoslav; Duvnjak, Marko (Jan 1, 1994). "The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides". Life Sciences. 54 (5): PL63–PL68. doi:10.1016/0024-3205(94)00796-9. ISSN 0024-3205. 
  6. Gjurasin, Miroslav; Miklic, Pavle; Zupancic, Bozidar; Perovic, Darko; Zarkovic, Kamelija; Brcic, Luka; Kolenc, Danijela; Radic, Bozo; Seiwerth, Sven (Feb 25, 2010). "Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury". Regulatory Peptides. 160 (1): 33–41. doi:10.1016/j.regpep.2009.11.005. ISSN 0167-0115. 


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history