HLA-DQB1

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HLA-DQB1 is a class II human leukocyte antigen gene.[1] HLA genes help the "immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria".[1][2]

Function[edit | edit source]

HLA associations are considered "hallmarks of autoimmune disease".[3] Different variations in HLA-DQB1 have been linked to celiac disease, narcolepsy, type I diabetes, autoimmune Addison's disease, rosacea and multiple sclerosis.[4]

ME/CFS[edit | edit source]

Lande et al. (2020) found two HLA associations that were more common in people with ME/CFS, with 19.2% of ME/CFS patients carrying one of the two HLA associations identified, compared to 12.2% of the control group.[3] The HLA associations more common in ME/CFS patients were HLA-C*07:04 and HLA-DQB1*03:03.[3] The 426 ME/CFS patients in the study met the Canadian Consensus Criteria for ME/CFS, except for four who met the International Consensus Criteria for ME.[3]

A small Norwegian trial found patients positive for HLA-DQB1*03:03 and/or HLA-C*07:04 were more likely to respond to cyclophosphamide than patients without those alleles, 83 vs. 43%.[5]

Notable studies[edit | edit source]

  • 2020, Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[3] - (Full text)
  • 2020, Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study[5] - (Full text)
  • 2021, Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci[6] (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 Genetics Home Reference. "Histocompatibility complex". Genetics Home Reference. Retrieved April 25, 2020.
  2. ↑ Merrian-Webster Dictionary. "Definition of HUMAN LEUKOCYTE ANTIGEN". Merrian-Webster Dictionary. Retrieved April 25, 2020.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Lande, Asgeir; Fluge, Øystein; Strand, Elin B.; Flåm, Siri T.; Sosa, DaysiD.; Mella, Olav; Egeland, Torstein; Saugstad, OlaD.; Lie, Benedicte A. (March 24, 2020). "Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Scientific Reports. 10 (1): 1–8. doi:10.1038/s41598-020-62157-x. ISSN 2045-2322.
  4. ↑ https://ghr.nlm.nih.gov/gene/HLA-DQB1 HLA-DQB1
  5. ↑ 5.0 5.1 Rekeland, Ingrid G.; Fosså, Alexander; Lande, Asgeir; Ktoridou-Valen, Irini; Sørland, Kari; Holsen, Mari; Tronstad, Karl J.; Risa, Kristin; Alme, Kine; Viken, Marte K.; Lie, Benedicte K.; Dahl, Olav; Mella, Olav; Fluge, Øystein (2020). "Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study". Frontiers in Medicine. 7: 162. doi:10.3389/fmed.2020.00162. ISSN 2296-858X. PMC 7201056. PMID 32411717.
  6. ↑ Hajdarevic, Riad; Lande, Asgeir; Rekeland, Ingrid; Rydland, Anne; Strand, Elin B.; Sosa, DaisyD.; Creary, Lisa E; Mella, Olav; Egeland, Torstein (November 1, 2021). "Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci". Brain, Behavior, and Immunity. 98: 101–109. doi:10.1016/j.bbi.2021.08.219. ISSN 0889-1591.
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