Dichloroacetic acid or DCA is an analogue of acetic acid. Salts of DCA may be used as drugs because they inhibit pyruvate dehydrogenase kinase. Dichloroacetic acid is has many alternative names including bichloroacetic acid, dichloroethanoic acid, Urner's liquid, potassium dichloroacetate, sodium dichloroacetate,DB08809, dichlorphos and 2,2-dichloroacetic acid. Dichloroacetic acid is a colorless liquid which is corrosive to metals and tissue.
Molecular formulas[edit | edit source]
Uses[edit | edit source]
In 1989, Canada approved DCA for applying to the skin for treating warts and for "cauterization and removal of a wide variety of skin and tissue lesions", though this was cancelled post-market. DCA has also been experimentally used by patients with brain cancer, but the effectiveness is unknown.
Theory[edit | edit source]
ME/CFS[edit | edit source]
Evidence[edit | edit source]
Notable studies and publications[edit | edit source]
- 2018, Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate: An open-label, proof-of-principle pilot trial - (Full text)
- 2018, Why do some ME/CFS patients benefit from treatment with sodium dichloroacetate, but others do not? - (Full text)
Clinicians[edit | edit source]
Risks and safety[edit | edit source]
Costs and availability[edit | edit source]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- PubChem. "Dichloroacetic acid". pubchem.ncbi.nlm.nih.gov. Retrieved May 21, 2020.
- Comhaire, F (May 2018). "Treating Patients Suffering From Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) With Sodium Dichloroacetate: An Open-Label, Proof-Of-Principle Pilot Trial". Medical hypotheses. PMID 29602463. Retrieved May 21, 2020.
- Comhaire, Frank (Nov 1, 2018). "Why do some ME/CFS patients benefit from treatment with sodium dichloroacetate, but others do not?". Medical Hypotheses. 120: 65–67. doi:10.1016/j.mehy.2018.08.014. ISSN 0306-9877.
myalgic encephalopathy - An alternate term that is sometimes used for myalgic encephalomyelitis, by people who believe the evidence for inflammation in ME is insufficient. This terminology reflects the belief that the "-itis" suffix implies inflammation.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.