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Cold shock protein
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Cold shock proteins (CSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions, in particular cold. Cold shock proteins include RNA binding motif 3 (RBM3)
RNA binding motif 3 (RBM3)[edit | edit source]
RBM3 may improve neurological health. In rodents, it has been linked linked to the regeneration of synapses[1][2] In a mouse model of Alzheimer's disease and prion disease, cooling induced upregulation of RBM3 and resulted in delayed on-set of diseases and prolonged survial.
In human subjects, upregulation of RBM3 was correlated with better prognosis in gastric[3] and colon[4] cancer.
See also[edit | edit source]
References[edit | edit source]
- ↑ Al-Astal, HI (2016). "Cellular Functions of RNA-Binding Motif Protein 3 (RBM3): Clues in Hypothermia, Cancer Biology and Apoptosis". Protein Pept Lett.
- ↑ "RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration". Nature. 2015.
- ↑ Fangpeng, Ye (2017). "High RNA-Binding Motif Protein 3 (RBM3) Expression is Independently Associated with Prolonged Overall Survival in Intestinal-Type Gastric Cancer". Med Sci Monit.
- ↑ Jang, HH (2017). "Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer". Anticancer Research.
