It is a critical co-enzyme of five carboxylases: acetyl-Coenzyme A carboxylase 1 and acetyl Co-enzyme A carboxylase 2,; propionyl Co-enzyme A carboxylase; β-methylcrotonyl Co-enzyme A carboxylase; and pyruvate Co-enzyme A carboxylase.
RDA[edit | edit source]
The RDA for adults is 30mcg (micrograms, or mcg) for both males and females in the United States. In Australia 30μg of biotin is recommended for adult men, and 25μg for women who are not pregnant or breastfeeding.
Deficiency[edit | edit source]
Excessive biotin is rare but can develop with prolonged consumption of raw egg whites total intravenous nutritional support lacking biotin. Women may develop subclinical biotin deficiency during pregnancy. Anticonvulsants increase the risk of Biotin deficiency.
Chronic fatigue syndrome[edit | edit source]
A blinded randomised controlled trial of a supplement containing 40mcg of biotin and many other vitamins, minerals and trace elements did not find any benefit to people with chronic fatigue syndrome.
Other diseases[edit | edit source]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- NIH. "Office of Dietary Supplements - Biotin". Retrieved Nov 17, 2018.
- nrv.gov.au (Mar 17, 2014). "Biotin". www.nrv.gov.au. Retrieved Nov 17, 2018.
- "Biotin". Linus Pauling Institute. Apr 22, 2014. Retrieved Nov 17, 2018.
- Brouwers, F. M.; Van Der Werf, S.; Bleijenberg, G.; Van Der Zee, L.; Van Der Meer, J. W. M. (Oct 2002). "The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: a double-blind randomized controlled trial". QJM: monthly journal of the Association of Physicians. 95 (10): 677–683. ISSN 1460-2725. PMID 12324640.
- "Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis - Full Text View - ClinicalTrials.gov". Retrieved Nov 17, 2018.
- "Effect of MD1003 in Spinal Progressive Multiple Sclerosis - Full Text View - ClinicalTrials.gov". Retrieved Nov 17, 2018.
enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.
chronic fatigue syndrome (CFS) - A controversial term, invented by the U.S. Centers for Disease Control, that generally refers to a collection of symptoms as “fatigue”. There have been multiple attempts to come up with a set of diagnostic criteria to define this term, but few of those diagnostic criteria are currently in use. Previous attempts to define this term include the Fukuda criteria and the Oxford criteria. Some view the term as a useful diagnostic category for people with long-term fatigue of unexplained origin. Others view the term as a derogatory term borne out of animus towards patients. Some view the term as a synonym of myalgic encephalomyelitis, while others view myalgic encephalomyelitis as a distinct disease.
randomized controlled trial (RCT) - A trial in which participants are randomly assigned to two groups, with one group receiving the treatment being studied and a control or comparison group receiving a sham treatment, placebo, or comparison treatment.