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An autoantibody is a type of antibody created by the immune system which targets the organism's own tissues, cells, or cell components. Many autoimmune diseases are caused by autoantibodies.

Autoantibodies found in ME/CFS and its comorbid conditions of POTS and OH[edit | edit source]

Various studies have detected autoantibodies in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) as well as in its common comorbid conditions of postural orthostatic tachycardia syndrome (POTS) and orthostatic hypotension (OH). The table below lists the autoantibodies found in ME/CFS, POTS and OH.

Autoantibodies Found in ME/CFS, POTS and OH
Autoantibody target ME/CFS POTS OH
Adrenergic receptor alpha 1  Yes[1]
Adrenergic receptor alpha 2
Adrenergic receptor beta 1   Yes[1] Yes[2]
Adrenergic receptor beta 2 Yes[3] Yes[1] Yes[2]
Muscarinic acetylcholine receptor M1 Yes[4] Yes[5]
Muscarinic acetylcholine receptor M2 Yes[5] Yes[2]
Muscarinic acetylcholine receptor M3 Yes[3] Yes[2]
Muscarinic acetylcholine receptor M4 Yes[3]
Nicotinic ganglionic acetylcholine receptor alpha 3 Yes[6]
Nicotinic ganglionic acetylcholine receptor beta 4 Yes[6]
Angiotensin II type 1 receptor Yes[7]
Dopamine D2 receptor Yes[4]
Mu-opioid receptor Yes[4]
Serotonin 5-HT1A receptor    Yes[4]
Serotonin (neurotransmitter) Yes[8]
Gangliosides Yes[8]
Microtubule-associated protein 2 (MAP2) Yes[9]
Phosphatidylinositol Yes[10]
Antinuclear antibodies (ANA) Yes[11][12]
Insoluble cellular antigens Yes[13]
Cardiolipin Yes[14]
Heat shock protein HSP60 Yes[15]
Anti-citrullinated protein Yes[16]

Learn more[edit | edit source]

References[edit | edit source]

  1. Li, Hongliang; Yu, Xichun; Liles, Campbell; Khan, Muneer; Vanderlinde-Wood, Megan; Galloway, Allison; Zillner, Caitlin; Benbrook, Alexandria; Reim, Sean (Feb 26, 2014). "Autoimmune basis for postural tachycardia syndrome". Journal of the American Heart Association. 3 (1): e000755. doi:10.1161/JAHA.113.000755. ISSN 2047-9980. PMC 3959717Freely accessible. PMID 24572257. 
  2. Yu, Xichun; Stavrakis, Stavros; Hill, Michael A.; Huang, Shijun; Reim, Sean; Li, Hongliang; Khan, Muneer; Hamlett, Sean; Cunningham, Madeleine W. (Jan 2012). "Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension". Journal of the American Society of Hypertension: JASH. 6 (1): 40–47. doi:10.1016/j.jash.2011.10.003. ISSN 1878-7436. PMC 3259269Freely accessible. PMID 22130180. 
  3. Loebel, Madlen; Grabowski, Patricia; Heidecke, Harald; Bauer, Sandra; Hanitsch, Leif G.; Wittke, Kirsten; Meisel, Christian; Reinke, Petra; Volk, Hans-Dieter (Feb 2016). "Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome". Brain, Behavior, and Immunity. 52: 32–39. doi:10.1016/j.bbi.2015.09.013. ISSN 1090-2139. PMID 26399744. 
  4. Tanaka, Susumu; Kuratsune, Hirohiko; Hidaka, Yoh; Hakariya, Yukiko; Tatsumi, Ke-Ita; Takano, Toru; Kanakura, Yuzuru; Amino, Nobuyuki (Aug 2003). "Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome". International Journal of Molecular Medicine. 12 (2): 225–230. ISSN 1107-3756. PMID 12851722. 
  5. 5.05.1 Dubey, Divyanshu; Hopkins, Steve; Vernino, Steven. "M1and M2 Muscarinic receptor antibodies among patients with Postural Orthostatic Tachycardia Syndrome: potential disease biomarker" (PDF). 
  6. 6.06.1 Watari, Mari; Nakane, Shunya; Mukaino, Akihiro; Nakajima, Makoto; Mori, Yukiko; Maeda, Yasuhiro; Masuda, Teruaki; Takamatsu, Koutaro; Kouzaki, Yanosuke (Feb 28, 2018). "Autoimmune postural orthostatic tachycardia syndrome". Annals of Clinical and Translational Neurology. 5 (4): 486–492. doi:10.1002/acn3.524. ISSN 2328-9503. PMC 5899914Freely accessible. PMID 29687025. 
  7. Yu, Xichun; Li, Hongliang; Murphy, Taylor A.; Nuss, Zachary; Liles, Jonathan; Liles, Campbell; Aston, Christopher E.; Raj, Satish R.; Fedorowski, Artur (Apr 4, 2018). "Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome". Journal of the American Heart Association. 7 (8). doi:10.1161/JAHA.117.008351. ISSN 2047-9980. PMID 29618472. 
  8. 8.08.1 Klein, R.; Berg, P. A. (Oct 16, 1995). "High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders". European Journal of Medical Research. 1 (1): 21–26. ISSN 0949-2321. PMID 9392689. 
  9. Vernon, Suzanne D.; Reeves, William C. (May 25, 2005). "Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome". Journal of Autoimmune Diseases. 2: 5. doi:10.1186/1740-2557-2-5. ISSN 1740-2557. PMC 1177983Freely accessible. PMID 15916704. 
  10. Maes, Michael; Mihaylova, Ivanka; Leunis, Jean-Claude (Dec 2007). "Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression". Neuro Endocrinology Letters. 28 (6): 861–867. ISSN 0172-780X. PMID 18063934. 
  11. Nishikai, Masahiko (Jun 2007). "[Antinuclear antibodies in patients with chronic fatigue syndrome]". Nihon Rinsho. Japanese Journal of Clinical Medicine. 65 (6): 1067–1070. ISSN 0047-1852. PMID 17561698. 
  12. Konstantinov, K; von Mikecz, A; Buchwald, D; Jones, J; Gerace, L; Tan, E M (Oct 15, 1996). "Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome". Journal of Clinical Investigation. 98 (8): 1888–1896. ISSN 0021-9738. PMID 8878441. 
  13. von Mikecz, A.; Konstantinov, K.; Buchwald, D. S.; Gerace, L.; Tan, E. M. (Feb 1997). "High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome". Arthritis and Rheumatism. 40 (2): 295–305. ISSN 0004-3591. PMID 9041942. 
  14. Hokama, Yoshitsugi; Campora, Cara Empey; Hara, Cynthia; Kuribayashi, Tina; Le Huynh, Diana; Yabusaki, Kenichi (2009). "Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome". Journal of Clinical Laboratory Analysis. 23 (4): 210–212. doi:10.1002/jcla.20325. ISSN 1098-2825. PMID 19623655. 
  15. Elfaitouri, Amal; Herrmann, Björn; Bölin-Wiener, Agnes; Wang, Yilin; Gottfries, Carl-Gerhard; Zachrisson, Olof; Pipkorn, Rϋdiger; Rönnblom, Lars; Blomberg, Jonas (2013). "Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis". PloS One. 8 (11): e81155. doi:10.1371/journal.pone.0081155. ISSN 1932-6203. PMC 3842916Freely accessible. PMID 24312270. 
  16. "Anti-citrullinated protein antibodies in CFS". 

Myalgic encephalomyelitis or chronic fatigue syndrome

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history