Talk:Prognosis for myalgic encephalomyelitis and chronic fatigue syndrome

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-- ~Njt (talk) 23:48, August 25, 2021 (UTC)[edit source | reply | new]

Updates[edit source | reply | new]

CDC prognosis section unchanged from 2018 but most of CDC pages have been updated since then.

sources[edit source | reply | new]

These may or may not be in the content already

  • 2021, Health, Wellbeing, and Prognosis of Australian Adolescents[1] (Full text)

By illness and patient group[edit source | reply | new]

Very long term follow up[edit source | reply | new]

  • 2012, Understanding Long-Term Outcomes of Chronic Fatigue Syndrome[2] [PMC MC3940158 (Full text)]
25 yr follow up
  • 2001, Thirteen-year follow-up of children and adolescents with chronic fatigue syndrome[3] (Full text)
Average age 23, follow up on average 8 years, mean disease duration 11.4 years at contact 2
  • 2014, Longitudinal follow-up of employment status in patients with chronic fatigue syndrome after mononucleosis[4] (Full text)
  • 2000, The course of severe chronic fatigue syndrome in childhood[5] (Full text)
Approx 2 year follow up
At contact 1, 9 (10%) were part-time or full- time employed. At contact 2, 49 (55%) were part-time or full-time employed. Logical regression analysis showed that FSS≥5 at contact 2 was associated with depression, arthralgia and long disease duration (all at contact 1). Conclusions: About half of younger patients with CFS with long-term incapacity for work experienced marked improvement including full-time or part-time employment showing better outcomes than expected. Risk factors for transition to permanent disability were depression, arthralgia and disease duration.
  • 2017, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer[6] (Full text)
It is generally accepted that young people with ME/CFS have a more favorable prognosis than adults. There have been few studies with sufficient numbers and duration of follow-up to be confident of the findings, but factors such as severity of symptoms or age at onset have not been shown to be reliable predictors of long-term outcomes. In a follow-up study of nearly 700 young people the average duration of illness of those who report having “recovered” was 4–5 years with a range from 1 to 15 years. By 5 years, 60% reported recovery, and by 12 years, 88% reported recovery. Of those who reported recovery, about one-third admitted to modifying their activities to remain feeling well (19). Several other studies found that although many patients improved, 20–48% showed no improvement or actually had worse fatigue and physical impairment at follow-up times ranging from 2 to 13 years (20–22). Even among those who report having completely recovered, many describe persistent symptoms that are not reported by healthy individuals (20).
Feedback from young people indicated that an important determinant of their functioning as adults was the effort made to enable them to remain engaged in education. This might have followed relatively unconventional pathways but it enabled them to remain socially connected and to feel they were able to achieve their aspirations fully or in part. From this group, more than 95% were either studying or working part or fulltime (23).
~Njt (talk) 23:48, August 25, 2021 (UTC)
  1. ↑ Josev, Elisha K.; Cole, Rebecca C.; Scheinberg, Adam; Rowe, Katherine; Lubitz, Lionel; Knight, Sarah J. (January 2021). "Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study". Journal of Clinical Medicine. 10 (16): 3603. doi:10.3390/jcm10163603.
  2. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940158/
  3. ↑ https://pediatrics.aappublications.org/content/107/5/994.short
  4. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named Hyland2014
  5. ↑ https://journals.sagepub.com/doi/abs/10.1177/014107680009300306
  6. ↑ https://www.frontiersin.org/articles/10.3389/fped.2017.00121/full

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

See Centers for Disease Control and Prevention.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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