Talk:Eightfold increase in ME/CFS incidence in the 1980s
lack of peer-reviewed info -- ~Njt (talk) 20:13, July 29, 2023 (UTC)[edit source | reply | new]
The poliovirus vaccine introduced in the late 1950s[edit source | reply | new]
One possible cause of the 1980s explosion in ME/CFS cases might have been the introduction of the polio vaccine in the late 1950s.[citation needed] This is because natural infection from poliovirus (which the vaccine eliminated from the wild) may confer some cross-immunity against other enteroviruses such as coxsackievirus B and echovirus, two viruses linked to ME/CFS. [1] [citation needed]
Prior infection with wild poliovirus likely does provide immunological cross-protection against coxsackievirus B, as a study from Estonia[2] details the differences between Estonian children immunised with the live attenuated polio vaccine, versus Finnish children immunised with the inactivated polio vaccine; it was found that the Estonian children given the live vaccine (which is closest to wild poliovirus infection) have a stronger T-cell responses against coxsackievirus B4, which the authors suggest may explain why type 1 diabetes (linked to coxsackievirus B4) is 3 times lower in Estonia compared to its neighbour Finland.[citation needed]
- Section above moved here due to lack of sources, see MEpedia guidelines ~Njt (talk) 20:13, July 29, 2023 (UTC)
- ↑ https://forums.phoenixrising.me/threads/did-the-introduction-of-the-polio-vaccine-cause-the-massive-rise-in-me-cfs-incidence-in-the-1980s.50642/.
- ↑ Juhela, S; HyöTy, H; Uibo, R; Meriste, S H; Uibo, O; LöNnrot, M; Halminen, M; Simell, O; Ilonen, J (December 24, 2001). "Comparison of enterovirus-specific cellular immunity in two populations of young children vaccinated with inactivated or live poliovirus vaccines". Clinical and Experimental Immunology. 117 (1): 100–105. doi:10.1046/j.1365-2249.1999.00954.x. ISSN 0009-9104. PMC 1905481. PMID 10403922.
