Mark VanNess

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Dr J. Mark VanNess, PhD, is a member of the scientific advisory committee of the Workwell Foundation which specializes in two-day cardiopulmonary exercise testing (2-day CPET) for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia and other fatiguing conditions. He has been working on ME/CFS since 1999, and is particularly interested in issues of autonomic dysfunction and mechanisms that produce post-exertional malaise.

Dr VanNess serves as department chair and Full Professor of Health, Exercise & Sport Sciences, Department of Sport Sciences, and an Adjunct Instructor at the College of Engineering, both at the University of the Pacific, Stockton, California.[1]

Education[edit | edit source]

  • 1990 - BS, Wheaton College, Illinois - Major: Exercise Physiology Minor: Biology[2]
  • 1993 - MS, California State University Sacramento - Thesis Title: "Lactate and Metabolic Responses to Controlled Frequency Breathing During Graded Tethered Swimming"[2]
  • 1997 - PhD, Florida State University - Dissertation Title: "Role of the Paraventricular Hypothalamic Nuclei and Neuropeptide Y in the Antihypertensive Effect of Food Restriction in Aortic Coarctation Hypertension"[2]
  • 1997-1999 - Post-Doctoral Training, Depts. of Pharmacology and Physiology, Univ. Texas Health Science Center. Gender differences in sodium-dependent hypertension[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Member of the Quality of Life/Functional Status (CPET)/Activity Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control and Prevention.[3]

Notable studies[edit | edit source]

  • 2001, Assessment of Functional Impairment by Cardiopulmonary Exercise Testing in Patients with Chronic Fatigue Syndrome[4]ABSTRACT
  • 2001, Chronic Fatigue Syndrome, Ampligen, and Quality of Life: A Phenomenological Perspective[5]ABSTRACT
  • 2002, Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome[6]ABSTRACT
  • 2003, Subclassifying chronic fatigue syndrome through exercise testing[7]ABSTRACT
  • 2005, Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS)[8]FULL TEXT
  • 2007, Legal and Scientific Considerations of the Exercise Stress Test[9]ABSTRACT
  • 2007, Diminished Cardiopulmonary Capacity During Post-Exertional Malaise[10]ABSTRACT
  • 2010, Post-exertional malaise in women with chronic fatigue syndrome[11]ABSTRACT
  • 2011, Diagnostic accuracy of symptoms characterising chronic fatigue syndrome[12]ABSTRACT
  • 2011, Reliability and validity of Short Form 36 Version 2 to measure health perceptions in a sub-group of individuals with fatigue[13]
  • 2013, Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome[14]FULL TEXT
  • 2018, Editorial - Checking our blind spots: current status of research evidence summaries in ME/CFS.[15](Introduction)
  • 2018, Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome[16]Abstract
  • 2019, Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?[17](Full text)
  • 2019, Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing[18](Full text)

Clinic location[edit | edit source]

The Workwell Foundation is based in Ripon, California.

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. http://www.pacific.edu/Academics/Schools-and-Colleges/College-of-the-Pacific/Academics/Departments-and-Programs/Health-Exercise-and-Sport-Sciences/Our-Faculty/Mark-VanNess.html
  2. 2.02.12.22.3 J. Mark VanNess (July 2015), Curriculum Vitae (PDF) (curriculum vitae)
  3. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
  4. VanNess, J Mark; Snell, Christopher R; Fredrickson, Dean M.; Strayer, David R.; Stevens, Staci R (2001), "Assessment of Functional Impairment by Cardiopulmonary Exercise Testing in Patients with Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 8 (3–4): 103–109, doi:10.1300/J092v08n03_09
  5. Snell, Christopher R; Stevens, Staci R; VanNess, J Mark (2001), "Chronic Fatigue Syndrome, Ampligen, and Quality of Life: A Phenomenological Perspective", Journal of Chronic Fatigue Syndrome, 8 (3–4): 117–121, doi:10.1300/J092v08n03_11
  6. Snell, Christopher R; VanNess, J Mark; Strayer, David R.; Stevens, Staci R (2002), "Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome", In Vivo, 16 (2): 107–9, PMID 12073768
  7. VanNess, J Mark; Snell, Christopher R; Strayer, David R.; Dempsey, IV, Line; Stevens, Staci R (2003), "Subclassifying chronic fatigue syndrome through exercise testing", Med Sci Sports Exerc, 35 (6): 908–913, doi:10.1249/01.MSS.0000069510.58763.E8, PMID 12783037
  8. Snell, Christopher R; VanNess, J Mark; Strayer, David R.; Stevens, Staci R (2005), "Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS)", In Vivo, 19 (2): 387–90, PMID 15796202
  9. Ciccolella, Margaret; Stevens, Staci R.; Snell, Christopher R.; Vanness, J. Mark (2007), "Legal and Scientific Considerations of the Exercise Stress Test", Journal of Chronic Fatigue Syndrome, 14 (2): 61–75, doi:10.1300/J092v14n02_06
  10. VanNess, J Mark; Snell, Christopher R; Stevens, Staci R (2007), "Diminished Cardiopulmonary Capacity During Post-Exertional Malaise", Journal of Chronic Fatigue Syndrome, 14 (2): 77–85, doi:10.1300/J092v14n02_07
  11. VanNess, J Mark; Stevens, Staci R; Bateman, Lucinda; Stiles, Travis L; Snell, Christopher R (January 4, 2010), "Post-exertional malaise in women with chronic fatigue syndrome", J Womens Health (Larchmt), 19 (2): 239–244, doi:10.1089/jwh.2009.1507, PMID 20095909
  12. Davenport, Todd E.; Stevens, Staci R.; Baroni, K; Vanness, J. Mark; Snell, Christopher R. (2011), "Diagnostic accuracy of symptoms characterizing chronic fatigue syndrome", Disabil Rehabil, 33 (19–20): 1768–75, doi:10.3109/09638288.2010.546936, PMID 21208154
  13. Davenport, Todd E.; Stevens, Staci R.; Baroni, K; Vanness, J. Mark; Snell, Christopher R. (2011), "Reliability and validity of Short Form 36 Version 2 to measure health perceptions in a sub-group of individuals with fatigue", Disabil Rehabil, 33 (25–26): 2596–2604, doi:10.3109/09638288.2011.582925, PMID 21682669
  14. Snell, Christopher R; Stevens, Staci R; Davenport, Todd E.; VanNess, J Mark (2013), "Discriminative Validity of Metabolic and Workload Measurements for Identifying People With Chronic Fatigue Syndrome", Physical Therapy, 93 (11): 1484–1492, doi:10.2522/ptj.20110368
  15. Davenport, Todd E.; Stevens, Staci R.; VanNess, J. Mark; Stevens, Jared; Snell, Christopher R. (July 17, 2018). "Checking our blind spots: current status of research evidence summaries in ME/CFS". Br J Sports Med: bjsports–2018–099553. doi:10.1136/bjsports-2018-099553. ISSN 0306-3674. PMID 30018122.
  16. Stevens, Staci; Snell, Chris; Stevens, Jared; Keller, Betsy; VanNess, J. Mark (2018). "Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Pediatrics. 6. doi:10.3389/fped.2018.00242. ISSN 2296-2360.
  17. Davenport, Todd E.; Lehnen, Mary; Stevens, Staci R.; VanNess, J. Mark; Stevens, Jared; Snell, Christopher R. (March 22, 2019). "Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00082. ISSN 2296-2360.
  18. Bouquet, Jerome; Li, Tony; Gardy, Jennifer L.; Kang, Xiaoying; Stevens, Staci; Stevens, Jared; VanNess, Mark; Snell, Christopher; Potts, James; Miller, Ruth R.; Morshed, Muhammad; McCabe, Mark; Parker, Shoshana; Uyaguari, Miguel; Tang, Patrick; Steiner, Theodore; Chan, Wee-Shian; De Souza, Astrid-Marie; Mattman, Andre; Patrick, David M.; Chiu, Charles Y. (March 21, 2019). "Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing". PLOS ONE. 14 (3): e0212193. doi:10.1371/journal.pone.0212193. ISSN 1932-6203. PMID 30897114.
  19. http://www.meresearch.org.uk/news/meeting-at-stormont-parliament/

two-day cardiopulmonary exercise test (CPET) - A diagnostic test which involves testing an ME/CFS patient exercising on an exercise machine, while monitoring their respiration, especially oxygen consumption. This test is repeated the following day in order to confirm the patient's inability to replicate the first-day performance. This test is thought to be the most objective way to detect post-exertional malaise.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

accuracy The "closeness of an observation to the true clinical state". With respect to diagnostic tests, "accuracy" means how specific and sensitive the test is.

virome The human virome is the collection of all viruses that are found in or on humans.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.