David M. Patrick, MD, FRCPC, MHSc, Infectious Disease physician and epidemiologist. Professor at University of British Columbia, School of Population and Public Health, Vancouver, British Columbia, Canada.
ME/CFS Common Data Element (CDE) Project[edit | edit source]
Member of the Biomarkers Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention. This working group reviewed data collection instruments widely used by investigators in the ME/CFS field, and either recommended their use unchanged or (more often) proposed some modifications.
Notable studies[edit | edit source]
- 2015, Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome(Abstract)
- 2019, Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing(Full text)
Talks and interviews[edit | edit source]
- 2016, CFS/ME Research Collaborative Conference - speech title: Researching a Syndrome: Findings from the UBC Complex Chronic Disease Study Group part one part two
Online presence[edit | edit source]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved Oct 11, 2019.
- Patrick, D. M., Miller, R. R., Steiner, T., Gardy, J. L., Parker, S. M., & Tang, P. (2015). Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome. Fatigue: Biomedicine, Health & Behavior, 3 (2), 122-125. doi:10.1080/21641846.2015.1024004
- Bouquet, Jerome; Li, Tony; Gardy, Jennifer L.; Kang, Xiaoying; Stevens, Staci; Stevens, Jared; VanNess, Mark; Snell, Christopher; Potts, James; Miller, Ruth R.; Morshed, Muhammad; McCabe, Mark; Parker, Shoshana; Uyaguari, Miguel; Tang, Patrick; Steiner, Theodore; Chan, Wee-Shian; De Souza, Astrid-Marie; Mattman, Andre; Patrick, David M.; Chiu, Charles Y. (Mar 21, 2019). "Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing". PLOS ONE. 14 (3): e0212193. doi:10.1371/journal.pone.0212193. ISSN 1932-6203. PMID 30897114.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
virome - The human virome is the collection of all viruses that are found in or on humans
post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others.
chronic disease - a disease or condition that usually lasts for 3 months or longer and may get worse over time
National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.
chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.