List of symptoms in ME CFS/ICC/PENE

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Jump to: navigation, search
Post-exertional Neuroimmune Exhaustion
(PENE) is a compulsory neuroimmune symptom in the International Consensus Criteria diagnostic criteria for Myalgic Encephalomyelitis.
PENE is also known as Post-exertional Malaise (PEM).

This cardinal feature is a pathological inability to produce sufficient energy on demand with prominent symptoms primarily in the neuroimmune regions. Characteristics are:

  • Marked, rapid physical and/or cognitive fatigability in response to exertion, which may be minimal such as activities of daily living or simple mental tasks, can be debilitating and cause a relapse.
  • Post-exertional symptom exacerbation: e.g. acute flu-like symptoms, pain and worsening of other symptoms.
  • Post-exertional exhaustion may occur immediately after activity or be delayed by hours or days.
  • Recovery period is prolonged, usually taking 24 hours or longer. A relapse can last days, weeks or longer.
  • Low threshold of physical and mental fatigability (lack of stamina) results in a substantial reduction in pre-illness activity level.

[1]

Learn more[edit | edit source]

References[edit | edit source]

post-exertional neuroimmune exhaustion (PENE) - An alternative term for post-exertional malaise (PEM), used by people who find that the word 'malaise' fails to capture the serious nature of the condition. Used in the Institute of Medicine (IOM) report.

post-exertional neuroimmune exhaustion (PENE) - An alternative term for post-exertional malaise (PEM), used by people who find that the word 'malaise' fails to capture the serious nature of the condition. Used in the Institute of Medicine (IOM) report.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.