Gailen D. Marshall, Jr, MD, PhD, is the R. Faser Triplett Sr. MD Chair of Allergy and Immunology; Professor of Medicine, Pediatrics and Pathology; Vice Chair for Research; Director, Division of Clinical Immunology and Allergy; and Chief, Laboratory of Behavioral Immunology Research at the University of Mississippi Medical Center, Jackson, Mississippi. He also serves as editor-in-chief of the Annals of Allergy, Asthma and Immunology journal.
Chronic Fatigue Syndrome Advisory Committee
- 2014, Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers. (FULL TEXT)
- 2012, Minimum data elements for research reports on CFS. Full text
Abstract: Chronic fatigue syndrome (CFS) is a debilitating condition that has received increasing attention from researchers in the past decade. However, it has become difficult to compare data collected in different laboratories due to the variability in basic information regarding descriptions of sampling methods, patient characteristics, and clinical assessments. The issue of variability in CFS research was recently highlighted at the NIH's 2011 State of the Knowledge of CFS meeting prompting researchers to consider the critical information that should be included in CFS research reports. To address this problem, we present our consensus on the minimum data elements that should be included in all CFS research reports, along with additional elements that are currently being evaluated in specific research studies that show promise as important patient descriptors for subgrouping of CFS. These recommendations are intended to improve the consistency of reported methods and the interpretability of reported results. Adherence to minimum standards and increased reporting consistency will allow for better comparisons among published CFS articles, provide guidance for future research and foster the generation of knowledge that can directly benefit the patient.
- 2005, Stress-associated changes in the steady state expression of latent Epstein-Barr Virus: Implications for Chronic Fatigue Syndrome and Cancer
Abstract - Antibodies to several Epstein-Barr virus (EBV)-encoded enzymes are observed in patients with different EBV-associated diseases. The reason for these antibody patterns and the role these proteins might play in the pathophysiology of disease, separate from their role in virus replication, is unknown. In this series of studies, we found that purified EBV deoxyuridine triphosphate nucleotidohydrolase (dUTPase) can inhibit the replication of human peripheral blood mononuclear cells in vitro and upregulate the production of TNF-alpha, IL-1beta, IL-6, IL-8, and IL-10. It also enhanced the ability of natural killer cells to lyse target cells. The EBV dUTPase also significantly inhibited the replication of mitogen-stimulated lymphocytes and the synthesis of IFN-gamma by cells isolated from lymph nodes and spleens obtained from mice inoculated with the protein. It also produced sickness behaviors known to be induced by some of the cytokines that were studied in the in vitro experiments. These symptoms include an increase in body temperature, a decrease in body mass and in physical activity. The data provide a new perspective on how an early nonstructural EBV-encoded protein can cause immune dysregulation and produce clinical symptoms observed in patients with chronic fatigue syndrome (CFS) separate from its role in virus replication and may serve as a new approach to help identify one of the etiological agents for CFS. The data also provide additional insight into the pathophysiology of EBV infection, inflammation, and cancer.
Talks & interviews
- HHS.gov, Chronic Fatigue Syndrome Advisory Committee Roster (PDF) (pdf)
- Fischer, David B.; William, Arsani H.; Strauss, Adam C.; Unger, Elizabeth R.; Jason, Leonard; Marshall, Jr, Gailen D.; Dimitrakoff, Jordan D. (2014), "Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers", Fatigue: Biomedicine, Health & Behavior, 2 (2): 93-109, doi:10.1080/21641846.2014.906066
- Jason, LA; Unger, ER; Dimitrakoff, JD; Fagin, AP; Houghton, M; Cook, DB; Marshall, GD, Jr; Klimas, N; Snell, C (2012), "Minimum data elements for research reports on CFS", Brain, Behavior, Immunology, 26 (3): 401-6, PMID 22306456, doi:10.1016/j.bbi.2012.01.014
- Glaser, R.; Padgett, D.A.; Litsky, M.L.; Baiocchi, R.A.; Yang, E.V.; Che, M.; Yeh, P-E.; Klimas, N.G.; Marshall, G.D.; Whiteside, T.; Herberman, R.; Kiecolt-Glaser, J.K.; Williams, M.V. (2005), "Stress-associated changes in the steady state expression of latent Epstein-Barr Virus: Implications for Chronic Fatigue Syndrome and Cancer", Brain, Behavior and Immunity, 19 (2): 91-103, PMID 15664781, doi:10.1016/j.bbi.2004.09.001