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Transforming growth factor beta
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Transforming growth factor beta (TGF-β ) is a cytokine secreted by many types of cells including macrophages.
TGF-β is disturbed in Marfan's syndrome and Loeys–Dietz syndrome.
It activates fibroblast proliferation[1] and stimulates fibroblasts to release connective tissue growth factor (CTGF).[2]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Strutz, Frank; Zeisberg, Michael; Renziehausen, Anja; Raschke, Birgit; Becker, Volker; Van Kooten, Cees; Müller, Gerhard A. (February 1, 2001). "TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)". Kidney International. 59 (2): 579–592. doi:10.1046/j.1523-1755.2001.059002579.x. ISSN 0085-2538.
- ↑ Grotendorst, Gary R. (September 1, 1997). "Connective tissue growth factor: a mediator of TGF-β action on fibroblasts". Cytokine & Growth Factor Reviews. 8 (3): 171–179. doi:10.1016/S1359-6101(97)00010-5. ISSN 1359-6101.
