Succinate dehydrogenase

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Succinate dehydrogenase or SDH is an enzyme involved in the Kreb's cycle. It oxidizes succinate to fumarate. It is also known as succinate-coenzyme Q reductase or respiratory Complex II.

ME/CFS[edit | edit source]

A small study of chronic fatigue syndrome patients found an inversion of the cytochrome oxidase/succinate dehydrogenase ratio in muscle biopses.[1]

A study of poliovirus found that polio infection rapidly decreases cellular oxygen consumption (and thus energy production through cellular respiration) by inhibiting succinate dehydrogenase and blocking mitochondrial electron transport.[2]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Vecchiet, L (April 1996). "Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome". Neuroscience Letters. 208: 117–20.
  2. Koundouris, A (May 2000). "Poliovirus Induces an Early Impairment of Mitochondrial Function by Inhibiting Succinate Dehydrogenase Activity". Biochemical and Biophysical Research Communications. 271: 610–4.