Pleconaril

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Pleconaril (Picovir) is an antiviral drug developed by Schering-Plough, now Merck. It has activity against Picornaviridae viruses including Enteroviruses and Rinoviruses.

Pleconaril has shown promise for the treatment of enteroviruses in a number of in vitro and clinical studies.[1][2][3][4][5]

The drug was available under compassionate use until 2003 and has not been approved by the FDA.

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References[edit | edit source]

  1. ↑ Rotbart, Harley A.; Webster, A. David (January 15, 2001), "Treatment of Potentially Life-Threatening Enterovirus Infections with Pleconaril", Clinical Infectious Diseases, 32 (2): 228–235, doi:10.1086/318452, ISSN 1058-4838, PMID 11170912, retrieved November 9, 2016
  2. ↑ Pevear, Daniel C.; Tull, Tina M.; Seipel, Martin E.; Groarke, James M. (September 1, 1999), "Activity of Pleconaril against Enteroviruses", Antimicrobial Agents and Chemotherapy, 43 (9): 2109–2115, ISSN 0066-4804, PMID 10471549, retrieved November 9, 2016
  3. ↑ Bauer, Sofia; Gottesman, Giora; Sirota, Lea; Litmanovitz, Ita; Ashkenazi, Shay; Levi, Itzhak (September 1, 2002), "Severe Coxsackie virus B infection in preterm newborns treated with pleconaril", European Journal of Pediatrics, 161 (9): 491–493, doi:10.1007/s00431-002-0929-5, ISSN 0340-6199, retrieved November 9, 2016
  4. ↑ Groarke, James M.; Pevear, Daniel C. (June 1, 1999), "Attenuated Virulence of Pleconaril-Resistant Coxsackievirus B3 Variants", Journal of Infectious Diseases, 179 (6): 1538–1541, doi:10.1086/314758, ISSN 0022-1899, PMID 10228078, retrieved November 9, 2016
  5. ↑ Abzug, Mark J.; Cloud, Gretchen; Bradley, John; Sánchez, Pablo J.; Romero, José; Powell, Dwight; Lepow, Martha; Mani, Chitra; Capparelli, Edmund V.; Blount, Sharon; Lakeman, Fred; Whitley, Richard J.; Kimberlin, David W.; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group (April 2003), "Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis", The Pediatric Infectious Disease Journal, 22 (4): 335–341, doi:10.1097/01.inf.0000059765.92623.70, ISSN 0891-3668, PMID 12690273

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)

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