Glutamate receptor, ionotropic, kinase 2

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Glutamate receptor, ionotropic, kinase 2 or Glutamate Ionotropic Receptor Kainate Type Subunit 2 or GRIK2.[1][2]

Other names[edit | edit source]

  • GluK2
  • GLUR6
  • MRT6
  • Glutamate Receptor Ionotropic, Kainate 2
  • Excitatory Amino Acid Receptor 4
  • EAA4
  • Glutamate Receptor 6
  • GluR-6[1]

Function[edit | edit source]

The glutamate receptors are the main excitatory neurotransmitter receptors in the human brain, and a variety of different GRIK2 gene mutations are associated with different neurodevelopment, neurological and psychiatric conditions.[3]

ME/CFS[edit | edit source]

A small study by Smith et al. (2011) found people with the G allele of rs2247215 (GRIK2) were more likely to have chronic fatigue syndrome, and CFS patientz had decreased GRIK2 expression patients.[2]

Notable studies[edit | edit source]

  • 2011, Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome[2] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 "GRIK2 Gene card". Gene cards. Retrieved April 1, 2022.
  2. 2.0 2.1 2.2 Smith, Alicia K.; Fang, Hong; Whistler, Toni; Unger, Elizabeth R.; Rajeevan, Mangalathu S. (2011). "Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome". Neuropsychobiology. 64 (4): 183–194. doi:10.1159/000326692. ISSN 0302-282X. PMC 3701888. PMID 21912186.
  3. "GRIK2 glutamate ionotropic receptor kainate type subunit 2 [Homo sapiens (human)] - Gene". National Center for Biotechnology Information. February 6, 2022. Retrieved March 31, 2022.