File:T-cell-types ME CFS.jpg

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Proportions of differentiated T cell populations in people with ME/CFS, people with MS and healthy controls. CD4+ (A) and CD8+ (B) T cells were analysed for CCR7, CD45RA, CD28, and CD57 co-expression to quantify proportions of T cells expressing combinations of these markers. The pie charts show the median average proportions of each cell type in each clinical group. In the bar and whisker plots, cell populations were compared between clinical groups for multiple comparisons for each cell differentiation subtype, with only significant (P < 0.05) results shown. The colour under each cell phenotype bar chart shows its representation in the pie charts.

  • P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

Key: Healthy controls (C), multiple sclerosis (MS), mild/moderate ME/CFS (ME-M), and severely affected ME/CFS (ME-S).

Author: (or citation)[edit | edit source]

Cliff JM, King EC, Lee J-S, Sepúlveda N, Wolf A-S, Kingdon C, Bowman E, Dockrell HM, Nacul L, Lacerda E and Riley EM (2019) Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Immunol. 10:796. doi: 10.3389/fimmu.2019.00796

Figure 5

Source: (e.g. internet address)[edit | edit source]

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full

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T cell A type of white blood cell which is mostly produced or matured in the thymus gland (hence T-cell) and is involved in the adaptive immune response on a cellular level. Also known as a T lymphocyte. (Learn more: www.youtube.com)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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current13:34, June 27, 2020Thumbnail for version as of 13:34, June 27, 2020765 × 1,276 (482 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== Proportions of differentiated T cell populations in people with ME/CFS, people with MS and healthy controls. CD4+ (A) and CD8+ (B) T cells were analysed for CCR7, CD45RA, CD28, and CD57 co-expre...

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