Fucosyltransferase 2 enzyme

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Fucosyltransferase 2 enzyme (FUT2) is an enzyme that adds fucose to N-glycans. Fucose N-glycans protect against intestinal dysbiosis and sepsis.[1] 20-30% of humans carry nonsense mutations of FUT2 and are "non-secretors."[2]

Microbiome[edit | edit source]

Genetic non-secretors of FUT2 and those who have reduced fucose N-glycans have reduced diversity, richness, and abundance of bifidobacteria[3], a commensal bacterium.

Disease risk[edit | edit source]

Non-secretors may have an increased risk of Crohn's disease[4] and Type 1 diabetes,[5] but a decreased risk of norovirus[6] and helicobacter pylori[7] infection.

Learn more[edit | edit source]

References[edit | edit source]


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history