Hydrocortisone: Difference between revisions
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==Clinical trials in ME/CFS== | ==Clinical trials in ME/CFS== | ||
A 1998 double-blind, randomized, placebo-controlled trial found that low dose hydrocortisone led to significant improvement in subjective scores but concluded that the resulting degree of adrenal suppression precludes its practical use.<ref>{{Cite journal | last = McKenzie | first = R|date=Sep 1998|title=Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial|url=https://www.ncbi.nlm.nih.gov/pubmed/9757853|journal=JAMA|volume=280|issue=12|pages=1061-6|via=}}</ref> | A 1998 double-blind, randomized, placebo-controlled trial found that low dose hydrocortisone led to significant improvement in subjective scores but concluded that the resulting degree of adrenal suppression precludes its practical use.<ref>{{Cite journal | last = McKenzie | first = R|date=Sep 1998 | title = Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial|url=https://www.ncbi.nlm.nih.gov/pubmed/9757853|journal=JAMA|volume=280|issue=12|pages=1061-6|via=}}</ref> | ||
In 1999, the Institute of Psychiatry, London, did a randomized crossover trial, in which [[Simon Wessely]] was an author, where low dose hydrocortisone treatments given to patients with [[chronic fatigue syndrome]] were found to reduce [[fatigue scores]] and that 28% of patients in the treatment group had reductions in scores that brought them to or close to normal in the short term.<ref>{{Cite journal | last = Cleare | first = AJ|date=February 1999|title=Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial|url=https://www.ncbi.nlm.nih.gov/pubmed/9989716|journal=Lancet|volume=353 | pages = 455-8|via=}}</ref> | In 1999, the Institute of Psychiatry, London, did a randomized crossover trial, in which [[Simon Wessely]] was an author, where low dose hydrocortisone treatments given to patients with [[chronic fatigue syndrome]] were found to reduce [[fatigue scores]] and that 28% of patients in the treatment group had reductions in scores that brought them to or close to normal in the short term.<ref>{{Cite journal | last = Cleare | first = AJ|date=February 1999 | title = Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial|url=https://www.ncbi.nlm.nih.gov/pubmed/9989716|journal=Lancet|volume=353 | pages = 455-8|via=}}</ref> | ||
A 2003 double-blind, randomized, placebo-controlled trial in combination with [[fludrocortisone]], a [[mineralocorticoid]], found no difference in self-reported outcomes.<ref>{{Cite journal | last = Blockmans | first = D|date=Jun 2003|title=Combination therapy with hydrocortisone and fludrocortisone does not improve symptoms in chronic fatigue syndrome: a randomized, placebo-controlled, double-blind, crossover study|url=https://www.ncbi.nlm.nih.gov/pubmed/12829200|journal=Am J Med|volume=114|issue=9 | pages = 736-41|via=}}</ref> | A 2003 double-blind, randomized, placebo-controlled trial in combination with [[fludrocortisone]], a [[mineralocorticoid]], found no difference in self-reported outcomes.<ref>{{Cite journal | last = Blockmans | first = D|date=Jun 2003 | title = Combination therapy with hydrocortisone and fludrocortisone does not improve symptoms in chronic fatigue syndrome: a randomized, placebo-controlled, double-blind, crossover study|url=https://www.ncbi.nlm.nih.gov/pubmed/12829200|journal=Am J Med|volume=114|issue=9 | pages = 736-41|via=}}</ref> | ||
==Learn more== | ==Learn more== | ||
Revision as of 01:19, October 19, 2022
Hydrocortisone is the name for the hormone cortisol when supplied as a medication.
Clinical trials in ME/CFS[edit | edit source]
A 1998 double-blind, randomized, placebo-controlled trial found that low dose hydrocortisone led to significant improvement in subjective scores but concluded that the resulting degree of adrenal suppression precludes its practical use.[1]
In 1999, the Institute of Psychiatry, London, did a randomized crossover trial, in which Simon Wessely was an author, where low dose hydrocortisone treatments given to patients with chronic fatigue syndrome were found to reduce fatigue scores and that 28% of patients in the treatment group had reductions in scores that brought them to or close to normal in the short term.[2]
A 2003 double-blind, randomized, placebo-controlled trial in combination with fludrocortisone, a mineralocorticoid, found no difference in self-reported outcomes.[3]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ McKenzie, R (September 1998). "Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial". JAMA. 280 (12): 1061–6.
- ↑ Cleare, AJ (February 1999). "Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial". Lancet. 353: 455–8.
- ↑ Blockmans, D (June 2003). "Combination therapy with hydrocortisone and fludrocortisone does not improve symptoms in chronic fatigue syndrome: a randomized, placebo-controlled, double-blind, crossover study". Am J Med. 114 (9): 736–41.
