Editing Fibromyalgia notable studies

'''Fibromyalgia notable studies''' houses the research for the [[Fibromyalgia]] (FM/FMS) page.

== Notable studies ==

=== 2000-2004 ===
*2002, Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia<ref name="Gracely2002">{{Cite journal | last = Gracely | first = Richard H. | author-link = | last2 = Petzke | first2 = Frank | authorlink2 = | last3 = Wolf | first3 = Julie M. | authorlink3 = | last4 = Clauw | first4 = Daniel J. | authorlink4 = Daniel Clauw | date = 2002 | title = Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia| url = https://onlinelibrary.wiley.com/doi/abs/10.1002/art.10225|journal=Arthritis & Rheumatism|language=en|volume=46|issue=5 | pages = 1333–1343|doi=10.1002/art.10225|issn=1529-0131|pmc=|pmid=|access-date=|quote=|via=}}</ref>
::Reported as '''Fibromyalgia Pain Isn't All In Patient's Heads, New Brain Study Finds'''

*2004, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754959/ A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing]<ref>{{Cite journal | last = Pimentel | first = M | last2 = Wallace | first2 = D | last3 = Hallegua | first3 = D | last4 = Chow | first4 = E | last5 = Kong | first5 = Y | last6 = Park | first6 = S | last7 = Lin | first7 = H | date = 2004 | title = A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754959/|journal=Annals of the Rheumatic Diseases|volume=63|issue=4 | pages = 450–452|doi=10.1136/ard.2003.011502|issn=0003-4967|pmid=15020342|via=}}</ref>

=== 2005-2009 ===
* 2006, [[pubmed:16556247|Prevalence of fibromyalgia syndrome in migraine patients.]]<ref>{{Cite journal | last = Ifergane | first = G. | last2 = Buskila | first2 =D. | last3 = Simiseshvely | first3 = N. | last4 = Zeev | first4 = K. | last5 = Cohen | first5 = H. | date = 2006 | title=Prevalence of fibromyalgia syndrome in migraine patients| url = https://www.ncbi.nlm.nih.gov/pubmed/16556247|journal=Cephalalgia: An International Journal of Headache|volume=26|issue=4 | pages = 451–456|doi=10.1111/j.1468-2982.2005.01060.x|issn=0333-1024|pmid=16556247|via=}}</ref>

*2007, [https://link.springer.com/article/10.1186/1744-8069-3-25 Neuroimaging revolutionizes therapeutic approaches to chronic pain]<ref name=":0">{{Cite journal | last = Borsook | first = David | last2 = Moulton | first2 = Eric A | last3 = Schmidt | first3 = Karl F | last4 = Becerra | first4 = Lino R | date = 2007-09-11 | title = Neuroimaging Revolutionizes Therapeutic Approaches to Chronic Pain | url =https://link.springer.com/article/10.1186/1744-8069-3-25|journal=Molecular Pain|language=en|volume=3|issue=1 | pages = 1744–8069-3-25|doi=10.1186/1744-8069-3-25|issn=1744-8069|pmid=17848191|via=}}</ref>
<blockquote>Chronic pain is a multidimensional process that now must be considered as a chronic degenerative disease not only affecting sensory and emotional processing, but also producing an altered [[brain]] state. Therapeutic interventions should be reconsidered in this context.<ref name=":0" /></blockquote>[[File:Schematic Examples of CNS Structural Changes in chronic pain.jpg|700px|thumb|center|Schematic Examples of CNS Structural Changes. Red circles signify decreased gray matter density relative to controls. A. Subjects with chronic back pain show decreases in gray matter density in bilateral dorsolateral prefrontal cortex (DLPFC) and right anterior thalamus (adapted from [25]). B. Patients with fibromyalgia show decreases in cingulate cortex (CC), medial prefrontal cortex (Med. PFC), parahippocampal gyrus (PHG) and insula (adapted from [27]). 3-D surface renderings were created using Freesurfer. Borsook et al. Molecular Pain 2007 3:25 [http://journals.sagepub.com/doi/10.1186/1744-8069-3-25 doi:10.1186/1744-8069-3-25]<ref name=":0" />]]

*2007, Clinical and Economic Characteristics of Patients With Fibromyalgia Syndrome<ref name="Weir2007">{{Cite journal | last = Lachaine | first = Jean | last2 = Beauchemin | first2 = Catherine | last3 = Landry | first3 = Pierre-Alexandre | date = May 2010 | title = Clinical and Economic Characteristics of Patients With Fibromyalgia Syndrome | url =https://journals.lww.com/clinicalpain/Fulltext/2010/05000/The_Validity_of_the_Neuropathic_Pain_Scale_for.3.aspx|journal=The Clinical Journal of Pain|language=en-US|volume=26|issue=4 | pages = 284–290|doi=10.1097/AJP.0b013e3181cf599f|issn=0749-8047}}</ref> [https://journals.lww.com/clinicalpain/Fulltext/2010/05000/The_Validity_of_the_Neuropathic_Pain_Scale_for.3.aspx (Abstract)]

*2008, Symptom Clusters in Fibromyalgia<ref name="Rutledge2009">{{Cite journal | last = Rutledge | first = Dana N. | author-link = | last2 = Mouttapa | first2 = Michele | authorlink2 = | last3 = Wood | first3 = Patrick B. | authorlink3 = | date = Sep 2009 | title = Symptom Clusters in Fibromyalgia| url = https://journals.lww.com/nursingresearchonline/fulltext/2009/09000/symptom_clusters_in_fibromyalgia__potential.8.aspx|journal=Nursing Research|language=en-US|volume=58|issue=5 | pages = 359–367|doi=10.1097/NNR.0b013e3181b499d2|issn=0029-6562|pmc=|pmid=|access-date=|quote=|via=}}</ref> [https://journals.lww.com/nursingresearchonline/fulltext/2009/09000/symptom_clusters_in_fibromyalgia__potential.8.aspx (Abstract)]

* 2009, [[pubmed:19170692|Fibromyalgia comorbidity in primary headaches.]]<ref>{{Cite journal | last = de Tommaso | first = M. | last2 = Sardaro | first2 = M. | last3 = Serpino | first3 = C. | last4 = Costantini | first4 = F. | last5 = Vecchio | first5 = E. | last6 = Prudenzano | first6 = M. Pia | last7 = Lamberti | first7 = P. | last8 = Livrea | first8 = P. | date = 2009 | title = Fibromyalgia comorbidity in primary headaches| url = https://www.ncbi.nlm.nih.gov/pubmed/19170692|journal=Cephalalgia: An International Journal of Headache|volume=29|issue=4 | pages = 453–464|doi=10.1111/j.1468-2982.2008.01754.x|issn=1468-2982|pmid=19170692|via=}}</ref>

=== 2010-2014 ===
* 2010, [[pubmed:20719340|Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.]]<ref>{{Cite journal | last = Nickel | first = J. Curtis | last2 = Tripp | first2 = Dean A. | last3 = Pontari | first3 = Michel | last4 = Moldwin | first4 = Robert | last5 = Mayer | first5 = Robert | last6 = Carr | first6 = Lesley K. | last7 = Doggweiler | first7 = Ragi | last8 = Yang | first8 = Claire C. | last9 = Mishra | first9 = Nagendra | date = 2010 | title=Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/20719340|journal=The Journal of Urology|volume=184|issue=4 | pages = 1358–1363|doi=10.1016/j.juro.2010.06.005|issn=1527-3792|pmid=20719340|via=}}</ref>

*2010, [https://www.psychiatrist.com/jcp/somatic/pain/pain-inhibition-is-deficient-chronic-widespread-pain/ Pain Inhibition Is Deficient in Chronic Widespread Pain but Normal in Major Depressive Disorder]<ref name="Normand2010">{{Cite journal | last = Normand | first = Edith | author-link = | last2 = Potvin | first2 = Stéphane | authorlink2 = | last3 = Gaumond | first3 = Isabelle | authorlink3 = | last4 = Cloutier | first4 = Guylaine | authorlink4 = | last5 = Corbin | first5 = Jean-François | authorlink5 = | last6 = Marchand | first6 = Serge | date = 2010-08-10 | title = Pain Inhibition Is Deficient in Chronic Widespread Pain but Normal in Major Depressive Disorder |url =https://www.psychiatrist.com/jcp/somatic/pain/pain-inhibition-is-deficient-chronic-widespread-pain/|journal=The Journal of Clinical Psychiatry|language=en-US|volume=72|issue=2 | pages = 219–224|doi=10.4088/JCP.08m04969blu|pmc=|pmid=|access-date=|quote=|via=}}</ref>

*2011, [https://www.mayoclinicproceedings.org/article/S0025-6196(11)60035-9/abstract Improving the Recognition and Diagnosis of Fibromyalgia]<ref name="Arnold2011">{{Cite journal | last = Arnold | first = Lesley M. | last2 = Clauw | first2 = Daniel J. | authorlink2 = Daniel Clauw | last3 = McCarberg | first3 = Bill H. | date = 2011-05-01 | title = Improving the Recognition and Diagnosis of Fibromyalgia| url = https://www.mayoclinicproceedings.org/article/S0025-6196(11)60035-9/abstract|journal=Mayo Clinic Proceedings|language=English|volume=86|issue=5 | pages = 457–464|doi=10.4065/mcp.2010.0738|issn=0025-6196}}</ref>

*2011, [https://doi.org/10.1186/1471-2377-11-55 Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia.]<ref name="Koroschetz2011">{{Cite journal | last = Koroschetz | first = Jana | last2 = Rehm | first2 = Stefanie E. | last3 = Gockel | first3 = Ulrich | last4 = Brosz | first4 = Mathias | last5 = Freynhagen | first5 = Rainer | last6 = Tölle | first6 = Thomas R. | last7 = Baron | first7 = Ralf | date = 2011-05-25 | title = Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia| url = https://doi.org/10.1186/1471-2377-11-55|journal=BMC Neurology|volume=11|issue=1 | pages = 1-8|doi=10.1186/1471-2377-11-55|issn=1471-2377|pmc=3125308|pmid=21612589}}</ref> 
 
*2011, [https://dx.org/10.1155/2012/184835 The Clinical Concept of Fibromyalgia as a Changing Paradigm in the Past 20 Years]<ref name="Fitzcharles2011">{{Cite journal | last = Fitzcharles | first = Mary-Ann | last2 = Yunus | first2 = Muhammad B. | date = 2012-10-29 | title = The Clinical Concept of Fibromyalgia as a Changing Paradigm in the Past 20 Years| url = https://dx.org/10.1155/2012/184835|journal=Pain Research and Treatment|volume=2012 | pages = 1–8|doi=10.1155/2012/184835|issn=2090-1542|pmc=3205680|pmid=22135738}}</ref>

*2011, [https://doi.org/10.1186/1477-7525-9-71 The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States]<ref name="Schaefer2011">{{Cite journal | last = Schaefer | first = Caroline | last2 = Chandran | first2 = Arthi | last3 = Hufstader | first3 = Meghan | last4 = Baik | first4 = Rebecca | last5 = McNett | first5 = Michael | last6 = Goldenberg | first6 = Don | last7 = Gerwin | first7 = Robert | last8 = Zlateva | first8 = Gergana | date = 2011-08-22 | title = The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States| url = https://doi.org/10.1186/1477-7525-9-71|journal=Health and Quality of Life Outcomes|volume=9|issue=1 | pages = 71|doi=10.1186/1477-7525-9-71|issn=1477-7525|pmc=3179696|pmid=21859448}}</ref>

*2012, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394355/ Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management]<ref name="Jahan2012">{{Cite journal | last = Jahan | first = Firdous | last2 = Nanji | first2 = Kashmira | last3 = Qidwai | first3 = Waris | last4 = Qasim | first4 = Rizwan | date = 2012  | title = Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394355/|journal=Oman Medical Journal|volume=27|issue=3 | pages = 192–195|doi=10.5001/omj.2012.44|issn=1999-768X|pmc=|pmid=22811766|via=}}</ref>  
<blockquote>Pathophysiology: Although the etiology remains unclear, characteristic alterations in the [[Sleep dysfunction|pattern of sleep]] and changes in neuroendocrine transmitters such as [[serotonin]], [[substance P]], growth hormone and [[cortisol]] suggest that regulation of the [[Autonomic nervous system|autonomic]] and neuro-endocrine system appears to be the basis of the syndrome. Fibromyalgia is not a life-threatening, deforming, or progressive disease. [[Anxiety]] and [[depression]] are the most common association. Aberrant pain processing, which can result in [[chronic pain]], may be the result of several interplaying mechanisms. [[Central sensitization]], blunting of inhibitory pain pathways and alterations in [[neurotransmitter]]s lead to aberrant neuro-chemical processing of sensory signals in the [[central nervous system|CNS]], thus lowering the threshold of pain and amplification of normal sensory signals causing constant pain.<ref name="Jahan2012" /></blockquote><blockquote>The frequent co-morbidity of fibromyalgia with mood disorders suggests a major role for the stress response and for [[neuroendocrine system|neuroendocrine]] abnormalities. The [[hypothalamic pituitary axis]] (HPA) is a critical component of the stress-adaptation response. In FMS, stress adaptation response is disturbed leading to stress induce symptoms. Psychiatric co-morbidity has been associated with FMS and needs to be identified during the consultation process, as this requires special consideration during treatment.<ref name="Jahan2012" /></blockquote>

[[File:Conditions Fibro.JPG|600px|thumb|center|'''Conditions associated with fibromyalgia.'''<br />
Source: Oman Med J 2012 May; 27(3):192-195. Jahan F, Nanji K, Qidwai W, Qasim R.[https://www.omjournal.org/articleDetails.aspx?coType=1&aId=234&se=Fibromyalgia%20Syndrome:%20An%20Overview%20of%20Pathophysiology,%20Diagnosis%20and%20Management Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management]. Oman Med J 2012 May; 27(3):192-195. Table 1.<ref name="Jahan2012" /> License: [http://creativecommons.org/licenses/by-nc/4.0/ CC BY-NC-4.0]]]


*2012, [https://www.researchgate.net/publication/230626400_Dysfunctional_endogenous_analgesia_during_exercise_in_patients_with_chronic_pain_To_exercise_or_not_to_exercise Dysfunctional endogenous analgesia during exercise in patients with chronic pain: To exercise or not to exercise?]<ref>{{Cite journal | last = Meeus | first = M. | author-link = Mira Meeus | last2 = Kosek | first2 = E. | authorlink2 = | last3 = Van Oosterwijck | first3 = J. | authorlink3 = Jessica Van Oosterwijck | last4 = Nijs | first4 = J. | authorlink4 = Jo Nijs | authorlink5 = | date = Sep 2011 | title = Dysfunctional endogenous analgesia during exercise in patients with chronic pain: To exercise or not to exercise?| url = http://dx.doi.org/10.1016/s1754-3207(11)70024-4|journal=European Journal of Pain Supplements|volume=5|issue=1 | pages = 8|doi=10.1016/s1754-3207(11)70024-4|issn=1754-3207|quote=|via=}}</ref>
*2014, [[pubmed:25350761|Aquatic exercise training for fibromyalgia.]]<ref>{{Cite journal | last = Bidonde | first = Julia | last2 = Busch | first2 = Angela J. | last3 = Webber | first3 = Sandra C. | last4 = Schachter | first4 = Candice L. | last5 = Danyliw | first5 = Adrienne | last6 = Overend | first6 = Tom J. | last7 = Richards | first7 = Rachel S. | last8 = Rader | first8 = Tamara | date = 2014-10-28 | title = Aquatic exercise training for fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pubmed/25350761|journal=The Cochrane Database of Systematic Reviews|issue=10| pages=CD011336|doi=10.1002/14651858.CD011336|issn=1469-493X|pmid=25350761}}</ref>

=== 2015-2019 ===

* 2015, [https://academic.oup.com/brain/article/138/3/604/333527?searchresult=1 Evidence for brain glial activation in chronic pain patients]<ref name=":7">{{Cite journal | last = Loggia | first = Marco L. | last2 = Chonde | first2 = Daniel B. | last3 = Akeju | first3 = Oluwaseun | last4 = Arabasz | first4 = Grae | last5 = Catana | first5 = Ciprian | last6 = Edwards | first6 = Robert R. | last7 = Hill | first7 = Elena | last8 = Hsu | first8 = Shirley | last9 = Izquierdo-Garcia | first9 = David | date = 2015-01-08 | title = Evidence for brain glial activation in chronic pain patients| url = https://academic.oup.com/brain/article/138/3/604/333527?searchresult=1|journal=Brain|language=en|volume=138|issue=3 | pages = 604–615|doi=10.1093/brain/awu377|issn=1460-2156}}</ref>

<blockquote>Whole-brain voxel-wise analyses. (A) Median SUVR map from healthy controls (n = 9) and patients with chronic LBP (n = 10) are presented. Matched-pairs tests (nine versus nine) revealed significantly higher TSPO levels in patients, in thalamus, pre- and postcentral gyri, and paracentral lobule (P < 0.05 corrected for multiple comparisons; permutation testing, 10 000 permutations). As two patients were matching the same controls, the analyses were performed first using the patient best matching the control. A second analysis was performed using the other patient, limiting our search to significant clusters from the first analysis, with identical results. (B) Boxplots for each of the four regions demonstrating statistically higher SUVRs in patients are shown for illustrative purposes. postc. = postcentral; g. = gyrus; parac. lob. = postcentral lobule; prec. = precentral.<ref name=":7" /></blockquote>



*2015, [http://onlinelibrary.wiley.com/doi/10.1111/1756-185X.12550/abstract Some oxidative and antioxidative parameters and their relationship with clinical symptoms in women with fibromyalgia syndrome]<ref>{{Cite journal | last = Fatima | first = Ghizal | last2 = Das | first2 = Siddharth Kumar | last3 = Mahdi | first3 = Abbas Ali | date = 2015-07-14 | title = Some oxidative and antioxidative parameters and their relationship with clinical symptoms in women with fibromyalgia syndrome | url =https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.12550|journal=International Journal of Rheumatic Diseases|language=en|volume=20|issue=1 | pages = 39–45|doi=10.1111/1756-185x.12550|issn=1756-1841}}</ref>

*2015, [http://onlinelibrary.wiley.com/doi/10.1002/acr.22626/full Understanding the Association of Fatigue With Other Symptoms of Fibromyalgia: Development of a Cluster Model] <ref>{{Cite journal | last = Lukkahatai | first = Nada | last2 = Walitt | first2 = Brian | last3 = Espina | first3 = Alexandra | last4 = Gelio | first4 = Alves | last5 = Saligan | first5 = Leorey N. | date = 2015-12-21 | title = Understanding the Association of Fatigue With Other Symptoms of Fibromyalgia: Development of a Cluster Model| url = https://onlinelibrary.wiley.com/doi/full/10.1002/acr.22626|journal=Arthritis Care & Research|language=en|volume=68|issue=1 | pages = 99–107|doi=10.1002/acr.22626|issn=2151-464X|pmc=|pmid=26017904|via=}}</ref>

*2015, [http://www.jneuro.com/neurology-neuroscience/evaluation-of-antiviral-antibodies-against-epsteinbarr-virus-and-neurotransmitters-in-patients-with-fibromyalgia.pdf Evaluation of Antiviral Antibodies against Epstein-Barr Virus and Neurotransmitters in Patients with Fibromyalgia]<ref>{{Cite journal | last = Reshkova | first = V | last2 = D | first2 = Kalinova | last3 = Milanov | first3 = Ivan | date = 2015-01-01 | title = Evaluation of Antiviral Antibodies against Epstein-Barr Virus and Neurotransmitters in Patients with Fibromyalgia| url = https://www.researchgate.net/publication/289245186_Evaluation_of_Antiviral_Antibodies_against_Epstein-Barr_Virus_and_Neurotransmitters_in_Patients_with_Fibromyalgia|journal=Journal of Neurology and Neuroscience|volume=6 | pages = 35|doi=10.21767/2171-6625.100035}}</ref>

*2015, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648619/ Sleep is associated with task-negative brain activity in fibromyalgia participants with comorbid chronic insomnia]<ref>{{Cite journal | last = Vatthauer | first = Karlyn E | last2 = Craggs | first2 = Jason G | last3 = Robinson | first3 = Michael E | last4 = Staud | first4 = Roland | last5 = Berry | first5 = Richard B | last6 = Perlstein | first6 = William M | last7 = McCrae | first7 = Christina S | date = 2015-11-12 | title = Sleep is associated with task-negative brain activity in fibromyalgia participants with comorbid chronic insomnia| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648619/|journal=Journal of Pain Research|volume=8 | pages = 819–827|doi=10.2147/JPR.S87501|issn=1178-7090|pmc=|pmid=26648751|issue=|via=|quote= | authorlink3 = | authorlink4 = Roland Staud | authorlink5 = }}</ref>

*2015, [https://biblio.ugent.be/publication/6993821 Cognitive performance is related to central sensitization in patients with chronic whiplash-associated disorders and fibromyalgia: a case-control study]<ref>{{Cite journal | last = Coppieters | first = Iris | last2 = Ickmans | first2 = Kelly | authorlink2 = Kelly Ickmans | last3 = Cagnie | first3 = Barbara | last4 = Nijs | first4 = Jo | last5 = De Pauw | first5 = Robby | last6 = Meeus | first6 = Mira | date = 2015 | title=Cognitive performance is related to central sensitization in patients with chronic whiplash-associated disorders and fibromyalgia: a case-control study| url = https://biblio.ugent.be/publication/6993821|journal=Pain Science in Motion congress, abstracts|issue=| pages=|quote= | author-link = Iris Coppieters|via=|volume=}}</ref>

*2015, [http://eujournal.org/index.php/esj/article/viewFile/6167/5952 Fibromyalgia: A search for markers and their evaluation throughout a treatment]<ref>{{Cite journal | last = Wyatt | first = H.J. | last2 = Day | first2 = N.W. | date = 1976-01-16 | title = Specific effects of neurotransmitter antagonists on ganglion cells in rabbit retina| url = https://www.ncbi.nlm.nih.gov/pubmed/1857|format = PDF | journal=Science (New York, N.Y.)|volume=191|issue=4223 | pages = 204–205|issn=0036-8075|pmid=1857|via=European Scientific Journal}}</ref>

*2015, [http://www.sciencedirect.com/science/article/pii/S2213158215001394 Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three-month physical exercise therapy]<ref>{{Cite journal | date = 2015-01-01 | title = Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy| url = https://www.sciencedirect.com/science/article/pii/S2213158215001394|journal=NeuroImage: Clinical|language=en|volume=9 | pages = 134–139|doi=10.1016/j.nicl.2015.08.004|issn=2213-1582}}</ref>

*2015, [https://journals.physiology.org/doi/full/10.1152/jn.00280.2015 Thalamic Mechanisms Underlying Alpha-Delta Sleep with Implications for Fibromyalgia]<ref name="Vijayan2015">{{Cite journal | last = Vijayan | first = Sujith | last2 = Klerman | first2 = Elizabeth B. | last3 = Adler | first3 = Gail K. | last4 = Kopell | first4 = Nancy J. | date = 2015-09-01 | title = Thalamic mechanisms underlying alpha-delta sleep with implications for fibromyalgia| url = https://journals.physiology.org/doi/full/10.1152/jn.00280.2015 |journal=Journal of Neurophysiology|volume=114|issue=3 | pages = 1923–1930|doi=10.1152/jn.00280.2015 |issn=0022-3077|pmc=PMC4575971|pmid=26245315}}</ref>
<blockquote>Our model also suggests that drugs that specifically target the somatosensory thalamus may be effective in treating fibromyalgia.<ref name="Vijayan2015" /></blockquote>

*2015, [http://synapse.koreamed.org/search.php?where=aview&id=10.3344/kjp.2015.28.3.169&code=0047KJP&vmode=FULL The Iceberg Nature of Fibromyalgia Burden: The Clinical and Economic Aspects]<ref name="Banafsheh2015">{{Cite journal | last = Banafsheh | first = Ghavidel-Parsa | last2 = Ali | first2 = Bidari | last3 = Alireza | first3 = Amir Maafi | last4 = Babak | first4 = Ghalebaghi | date = 2015-07-01 | title = The Iceberg Nature of Fibromyalgia Burden: The Clinical and Economic Aspects| url = https://synapse.koreamed.org/search.php?where=aview&id=10.3344/kjp.2015.28.3.169&code=0047KJP&vmode=FULL|journal=The Korean Journal of Pain|language=en|volume=28|issue=3|doi=10.3344/kjp.2015.28.3.169&code=0047kjp&vmode=full|issn=2005-9159}}</ref>

*2015, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499983/ The effects of aquatic, isometric strength-stretching and aerobic exercise on physical and psychological parameters of female patients with fibromyalgia syndrome]<ref>{{Cite journal | last = Sevimli | first = Dilek | last2 = Kozanoglu | first2 = Erkan | last3 = Guzel | first3 = Rengin | last4 = Doganay | first4 = Ahmet | date = 2015 | title = The effects of aquatic, isometric strength-stretching and aerobic exercise on physical and psychological parameters of female patients with fibromyalgia syndrome | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499983/|journal=Journal of Physical Therapy Science|volume=27|issue=6 | pages = 1781–1786|doi=10.1589/jpts.27.1781|issn=0915-5287|pmid=26180320|via=}}</ref>



[[File:Cytokines Fibro.jpg|200px|thumb|left|The probability densities of CCC test scores of 119 controls, 160 FM patients, 100 SLE patients and 98 RA patients<ref name=":1" />]]


*2015, [http://www.ncbi.nlm.nih.gov/pubmed/25377646 Cytokine and chemokine profiles in fibromyalgia, rheumatoid arthritis, and systemic lupus erythematosus: a potentially useful tool in differential diagnosis.]<ref name=":1">{{Cite journal | last = Wallace | first = Daniel J. | last2 = Gavin | first2 = Igor M. | last3 = Karpenko | first3 = Oleksly | last4 = Barkhordar | first4 = Farnaz | last5 = Gillis | first5 = Bruce S. | date = 2015 | title=Cytokine and chemokine profiles in fibromyalgia, rheumatoid arthritis and systemic lupus erythematosus: a potentially useful tool in differential diagnosis| url = https://www.ncbi.nlm.nih.gov/pubmed/25377646|journal=Rheumatology International|volume=35|issue=6 | pages = 991–996|doi=10.1007/s00296-014-3172-2|issn=1437-160X|pmc=|pmid=25377646|via=}}</ref>

<blockquote>Nearly 500 FM, autoimmune and healthy control patients underwent testing for cytokine/chemokine activity after mitogenic stimulation. Using a numerical score, all three groups had unique patterns with FM patients demonstrating less response to stimulation. This cytokine profile test had a 93 % sensitivity and an 89.4 % specificity for the diagnosis of FM. We also found that these profiles are relatively sensitive and specific for FM compared to SLE and RA. It remains unclear if these differences are directly related to the pathogenesis of FM.<ref name=":1" /></blockquote>

*2015, [http://onlinelibrary.wiley.com/doi/10.1002/art.39043/abstract The Somatosensory Link in Fibromyalgia: Functional Connectivity of the Primary Somatosensory Cortex Is Altered by Sustained Pain and Is Associated With Clinical/Autonomic Dysfunction]<ref>{{Cite journal | last = Kim | first = Jieun | last2 = Loggia | first2 = Marco L. | last3 = Cahalan | first3 = Christine M. | last4 = Harris | first4 = Richard E. | last5 = Beissner | first5 = Florian | last6 = Garcia | first6 = Ronald G. | last7 = Kim | first7 = Hyungjun | last8 = Barbieri | first8 = Riccardo | last9 = Wasan | first9 = AjayD. | date = 2015-04-27 | title = The Somatosensory Link in Fibromyalgia: Functional Connectivity of the Primary Somatosensory Cortex Is Altered by Sustained Pain and Is Associated With Clinical/Autonomic Dysfunction | url =https://onlinelibrary.wiley.com/doi/abs/10.1002/art.39043|journal=Arthritis & Rheumatology|language=en|volume=67|issue=5 | pages = 1395–1405|doi=10.1002/art.39043|issn=2326-5191|pmc=|pmid=25622796|via=}}</ref>
*2015, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372601/ Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia]<ref>{{Cite journal | last = Cerdá-Olmedo | first = Germán | last2 = Mena-Durán | first2 = Armando Vicente | last3 = Monsalve | first3 = Vicente | last4 = Oltra | first4 = Elisa | date = 2015-03-24 | title = Identification of a MicroRNA Signature for the Diagnosis of Fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372601/|journal=PLoS ONE|volume=10|issue=3| pages=|doi=10.1371/journal.pone.0121903|issn=1932-6203|pmid=25803872|via=}}</ref>

*2016, [https://www.ncbi.nlm.nih.gov/pubmed/27713820 Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice.]<ref>{{Cite journal | last = Oezel | first = Lisa | last2 = Then | first2 = Hanna | last3 = Jung | first3 = Anna L. | last4 = Jabari | first4 = Samir | last5 = Bonaterra | first5 = Gabriel A. | last6 = Wissniowski | first6 = Thaddeus T. | last7 = Önel | first7 = Susanne F. | last8 = Ocker | first8 = Matthias | last9 = Thieme | first9 = Kati | date = 2016 | title=Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice | url =https://www.ncbi.nlm.nih.gov/pubmed/27713820|journal=Pharmacology Research & Perspectives|volume=4|issue=5| pages = e00248|doi=10.1002/prp2.248|issn=2052-1707|pmc=|pmid=27713820|via=}}</ref>

*2016, [http://bjpo.rcpsych.org/content/2/4/275 The association between borderline personality disorder, fibromyalgia and chronic fatigue syndrome: systematic review]<ref name=":27">{{Cite journal | last = Penfold | first = Sarah | last2 = Denis | first2 = Emily St | last3 = Mazhar | first3 = Mir Nadeem | date = Jul 2016 | title = The association between borderline personality disorder, fibromyalgia and chronic fatigue syndrome: systematic review | url =https://www.cambridge.org/core/journals/bjpsych-open/article/association-between-borderline-personality-disorder-fibromyalgia-and-chronic-fatigue-syndrome-systematic-review/119F3075289EBCC85D454D8D182DB1A6|journal=BJPsych Open|language=en|volume=2|issue=4 | pages = 275–279|doi=10.1192/bjpo.bp.115.002808|issn=2056-4724}}</ref> 

<blockquote>There does not appear to be firm and consistent evidence to support the hypothesis that the prevalence of BPD ([[Borderline Personality Disorder]]) would be higher in individuals with fibromyalgia compared with the general population.<ref name=":27" /></blockquote>

*2016, [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161574 Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning]<ref name=":2">{{Cite journal | last = Garcia-Martin | first = Elena | last2 = Garcia-Campayo | first2 = Javier | last3 = Puebla-Guedea | first3 = Marta | last4 = Ascaso | first4 = Francisco J. | last5 = Roca | first5 = Miguel | last6 = Gutierrez-Ruiz | first6 = Fernando | last7 = Vilades | first7 = Elisa | last8 = Polo | first8 = Vicente | last9 = Larrosa | first9 = Jose M. | date = 2016-09-01 | title = Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning | url =http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161574|journal=PLOS ONE|language=en|volume=11|issue=9| pages = e0161574|doi=10.1371/journal.pone.0161574|issn=1932-6203|pmc=|pmid=27584145|via=}}</ref>
<blockquote>Fibromyalgia causes subclinical axonal damage in the RNFL that can be detected using innocuous and non-invasive OCT, even in the early disease stages. The impact on the RNFL in the temporal sectors is greater in patients with biologic fibromyalgia, suggesting the presence of neurodegenerative processes in this subgroup of patients with fibromyalgia.<ref name=":2" /><br />
</blockquote>[[File:Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning.PNG|700px|thumb|center|Fig 1. Representation and interpretation of the report from the Axonal application of the Spectralis optical coherence tomography in a control (left side) and in a patient with fibromyalgia and retina nerve fiber layer thinning (right side)<ref>{{Cite journal | last = Garcia-Martin | first = Elena | last2 = Garcia-Campayo | first2 = Javier | last3 = Puebla-Guedea | first3 = Marta | last4 = Ascaso | first4 = Francisco J. | last5 = Roca | first5 = Miguel | last6 = Gutierrez-Ruiz | first6 = Fernando | last7 = Vilades | first7 = Elisa | last8 = Polo | first8 = Vicente | last9 = Larrosa | first9 = Jose M. | date = 2016-09-01 | title = Fibromyalgia Is Correlated with Retinal Nerve Fiber Layer Thinning | url =http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161574|journal=PLOS ONE|language=en|volume=11|issue=9| pages = e0161574|doi=10.1371/journal.pone.0161574|issn=1932-6203}}</ref>]]

*2016, [https://www.ncbi.nlm.nih.gov/pubmed/26272057 The prevalence of severe fatigue in rheumatic diseases: an international study.]<ref>{{Cite journal | last = Overman | first = Cécile L. | last2 = Kool | first2 = Marianne B. | last3 = Da Silva | first3 = José A.P. | last4 = Geenen | first4 = Rinie | date = 2016 | title=The prevalence of severe fatigue in rheumatic diseases: an international study| url = https://www.ncbi.nlm.nih.gov/pubmed/26272057|journal=Clinical Rheumatology|volume=35|issue=2 | pages = 409–415|doi=10.1007/s10067-015-3035-6|issn=1434-9949|pmid=26272057|via=}}</ref> 

*2016, [http://journals.lww.com/clinicalpain/Abstract/2016/04000/Characteristics_of_Disturbed_Sleep_in_Patients.4.aspx Characteristics of Disturbed Sleep in Patients With Fibromyalgia Compared With Insomnia or With Pain-Free Volunteers]<ref>{{Cite journal | last = Roth | first = Thomas | last2 = Bhadra-Brown | first2 = Pritha | last3 = Pitman | first3 = Verne W. | last4 = Roehrs | first4 = Timothy A. | last5 = Resnick | first5 = E. Malca | date = 2016 | title=Characteristics of Disturbed Sleep in Patients With Fibromyalgia Compared With Insomnia or With Pain-Free Volunteers| url = https://journals.lww.com/clinicalpain/Abstract/2016/04000/Characteristics_of_Disturbed_Sleep_in_Patients.4.aspx|journal=The Clinical Journal of Pain|language=en-US|volume=32|issue=4 | pages = 302–307|doi=10.1097/AJP.0000000000000261|issn=0749-8047|via=}}</ref>

*2016, [https://www.ncbi.nlm.nih.gov/pubmed/26218005 Is Efficacy of Milnacipran in Fibromyalgia Predictable? A Data Mining Analysis of Baseline and Outcome Variables.]<ref>{{Cite journal | last = Abtroun | first = Lilia | last2 = Bunouf | first2 = Pierre | last3 = Gendreau | first3 = Roger M. | last4 = Vitton | first4 = Olivier | date = 2016 | title=Is the Efficacy of Milnacipran in Fibromyalgia Predictable? A Data-Mining Analysis of Baseline and Outcome Variables| url = https://www.ncbi.nlm.nih.gov/pubmed/26218005|journal=The Clinical Journal of Pain|volume=32|issue=5 | pages = 435–440|doi=10.1097/AJP.0000000000000284|issn=1536-5409|pmid=26218005|via=}}</ref>

*2017, [https://www.ncbi.nlm.nih.gov/pubmed/28614420# The degree of cardiac baroreflex involvement during active standing is associated with the quality of life in fibromyalgia patients.]<ref>{{Cite journal | last = Zamunér | first = Antonio Roberto | last2 = Porta | first2 = Alberto | last3 = Andrade | first3 = Carolina Pieroni | last4 = Forti | first4 = Meire | last5 = Marchi | first5 = Andrea | last6 = Furlan | first6 = Raffaello | last7 = Barbic | first7 = Franca | last8 = Catai | first8 = Aparecida Maria | last9 = Silva | first9 = Ester | date = 2017 | title=The degree of cardiac baroreflex involvement during active standing is associated with the quality of life in fibromyalgia patients| url = https://www.ncbi.nlm.nih.gov/pubmed/28614420#|journal=PloS One|volume=12|issue=6| pages = e0179500|doi=10.1371/journal.pone.0179500|issn=1932-6203|pmid=28614420|via=}}</ref> ([[Orthostatic intolerance|Orthostatic intollerance.]]) 

*2017, [https://www.dovepress.com/evidence-of-both-systemic-inflammation-and-neuroinflammation-in-fibrom-peer-reviewed-fulltext-article-JPR Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma]<ref>{{Cite journal | last = Bäckryd | first = Emmanuel | last2 = Tanum | first2 = Lars | last3 = Lind | first3 = Anne-Li | last4 = Larsson | first4 = Anders | last5 = Gordh | first5 = Torsten | date = 2017 | title=Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma| url = https://www.dovepress.com/evidence-of-both-systemic-inflammation-and-neuroinflammation-in-fibrom-peer-reviewed-fulltext-article-JPR|journal=Journal of Pain Research|language=English|volume= 10 | pages = 515–525|doi=10.2147/JPR.S128508|issn=1178-7090|via=}}</ref>


[[File:FM-Pressure Pain Pattern.jpg|300px|thumb|right|Figure 2<ref name=":3" />]]


*2017, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161739/ Towards a neurophysiological signature for fibromyalgia.]<ref name=":3">{{Cite journal | last = López-Solà | first = Marina | last2 = Woo | first2 = Choong-Wan | last3 = Pujol | first3 = Jesus | last4 = Deus | first4 = Joan | last5 = Harrison | first5 = Ben J. | last6 = Monfort | first6 = Jordi | last7 = Wager | first7 = TorD. | date = 2017 | title=Towards a neurophysiological signature for fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pubmed/27583567|journal=Pain|volume=158|issue=1 | pages = 34–47|doi=10.1097/j.pain.0000000000000707|issn=1872-6623|pmid=27583567|via=}}</ref>

<blockquote>Here, we identify a set of three brain patterns based on fMRI responses to pressure pain and non-painful multisensory stimulation. These patterns, taken together, discriminate FM from matched healthy controls with 92% sensitivity and 94% specificity.<ref name=":3" /></blockquote>

<blockquote>Figure 2. Multivariate brain pattern that predicts fibromyalgia status on the basis of brain activation during painful (pressure) stimulation. Positive weight values reflect higher pain-evoked activation in FM patients relative to healthy participants, whereas negative weight values reflect reduced pain-evoked activation in FM patients. A. SVM pattern of whole-brain voxel weights that optimizes classification of FM patients and healthy participants. We provide the voxel-by-voxel weights for three representative regions (anterior SII, right dorsolateral and dorsomedial PFC) to illustrate the concept of weighted pattern. B. Regions whose voxel weights contributed most reliably to the prediction of FM status (q<0.05 FDR-corrected for the first two rows; p-uncorrected<0.001 to further illustrate the findings).<ref name=":3" /></blockquote>

*2017, [https://pubmed.ncbi.nlm.nih.gov/29392213/ Diagnostic confounders of chronic widespread pain: not always fibromyalgia]<ref name="Hauser2017">{{Cite journal | last = Häuser | first = Winfried | last2 = Perrot | first2 = Serge | last3 = Sommer | first3 = Claudia | last4 = Shir | first4 = Yoram | last5 = Fitzcharles | first5 = Mary-Ann | date = May 2017 | title = Diagnostic confounders of chronic widespread pain: not always fibromyalgia| url = https://pubmed.ncbi.nlm.nih.gov/29392213/|journal=Pain Reports|volume=2|issue=3| pages = e598|doi=10.1097/PR9.0000000000000598|issn=2471-2531|pmc=5741304|pmid=29392213}}</ref>

*2018, [https://www.ncbi.nlm.nih.gov/pubmed/29149437 A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia.]<ref>{{Cite journal | last = Boomershine | first = Chad S. | last2 = Koch | first2 = Todd A. | last3 = Morris | first3 = David | date = 2018 | title = A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pubmed/29149437|journal=Rheumatology and Therapy|volume=5|issue=1 | pages = 271–281|doi=10.1007/s40744-017-0088-9|issn=2198-6576|pmid=29149437|via=}}</ref>

*2018, [http://www.jrheum.org/content/early/2018/07/09/jrheum.180083 Primary and Secondary Fibromyalgia Are The Same: The Universality of Polysymptomatic Distress]<ref name=":29">{{Cite journal | last = Wolfe | first = Frederick | last2 = Walitt | first2 = Brian | last3 = Rasker | first3 = Johannes J. | last4 = Häuser | first4 = Winfried | date = 2018-07-15 | title = Primary and Secondary Fibromyalgia Are The Same: The Universality of Polysymptomatic Distress| url = http://www.jrheum.org/content/early/2018/07/09/jrheum.180083|journal=The Journal of Rheumatology|volume=46|issue=2 | pages = 204-212|issn=0315-162X|pmid=30008459}}</ref> "PFM and SFM are equivalent regarding symptom burden."<ref name=":29" />

*2018, [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198625 SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study]<ref name=":4">{{Cite journal | last = Zhang | first = Zhifang | last2 = Feng | first2 = Jinong | last3 = Mao | first3 = Allen | last4 = Le | first4 = Keith | last5 = Placa | first5 = Deirdre La | last6 = Wu | first6 = Xiwei | last7 = Longmate | first7 = Jeffrey | last8 = Marek | first8 = Claudia | last9 = Amand | first9 = R. Paul S t | date = 2018-06-21 | title = SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study| url = http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198625|journal=PLOS ONE|language=en|volume=13|issue=6| pages = e0198625|doi=10.1371/journal.pone.0198625|issn=1932-6203|pmid=29927949|via=}}</ref>

<blockquote>SNPs with significant TDTs were found in 36% of the cohort for CCL11 and 12% for MEFV, along with a protein variant in CCL4 (41%) that affects CCR5 down-regulation, supporting an immune involvement for FM.<ref name=":4" /></blockquote>

<gallery widths="220px" heights="220px" class="center">
File:Journal.pone.0198625.g001.PNG|Fig 1. Expression of wild type and variant (Ala23Thr) CCL11
File:Journal.pone.0198625.g003.PNG|Fig 3. Functional analyses of WT vs varCCL4 in immature dendritic cells or CEM.NKR CCR5 T-cells
File:Journal.pone.0198625.g004.PNG|Fig 4. Wild type versus varCCL4 in the down-regulation of CCR5 in a 9 day mixed lymphocyte culture
</gallery>



*2018, [https://journals.lww.com/psychosomaticmedicine/Fulltext/2018/06000/Cognitive_Impairment_in_Fibromyalgia__A.5.aspx Cognitive Impairment in Fibromyalgia: A Meta-Analysis of Case-Control Studies]<ref name="Wu2018">{{Cite journal| url = https://journals.lww.com/psychosomaticmedicine/Fulltext/2018/06000/Cognitive_Impairment_in_Fibromyalgia__A.5.aspx|pmid=29528888 | title = Cognitive Impairment in Fibromyalgia: A Meta-Analysis of Case-Control Studies | last = Wu | first = Yu-Lin | last2 = Huang | first2 = Chun-Jen | date = 2018|journal=Psychosomatic medicine|volume = 80|issue =5 | pages =432-438 | last3 = Fang | first3 = Su-Chen | last4 = Ko | first4 = Ling-Hsin | last5 = Tsai | first5 = Pei-Shan}}</ref>

*2018, [https://www.chiropractic.ca/wp-content/uploads/2018/05/107243-2_Chiro_62_1d_Bourgaize.pdf A comparison of the clinical manifestation and pathophysiology of myofascial pain syndrome and fibromyalgia: implications for differential diagnosis and management]<ref>{{Cite journal | last = Bourgaize | first = Sheryl | last2 = Newton | first2 = Genevieve | last3 = Kumbhare | first3 = Dinesh | last4 = Srbely | first4 = John | date = 2018 | title = A comparison of the clinical manifestation and pathophysiology of myofascial pain syndrome and fibromyalgia: implications for differential diagnosis and management| url = https://www.chiropractic.ca/wp-content/uploads/2018/05/107243-2_Chiro_62_1d_Bourgaize.pdf | format = PDF | journal=Journal of the Canadian Chiropractic Assoc.|volume=62|issue=1 | pages = 26-41}}</ref>{{Rp|Table 1 "Summary of the pathophysiology of fibromyalgia and myofascial pain syndrome." p. 29|via=}}
::See Table 1 "Summary of the pathophysiology of fibromyalgia and myofascial pain syndrome." p. 29 (p. 4 of PDF)

*2018, [https://www.sciencedirect.com/science/article/pii/S0889159118302423?via%3Dihub Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation]<ref name=":5">{{Cite journal | last = Albrecht | first = Daniel S. | last2 = Forsberg | first2 = Anton | last3 = Sandstrom | first3 = Angelica | last4 = Bergan | first4 = Courtney | last5 = Kadetoff | first5 = Diana | last6 = Protsenko | first6 = Ekaterina | last7 = Lampa | first7 = Jon | last8 = Lee | first8 = Yvonne C. | last9 = Höglundi | first9 = Caroline Olgar t | date = 2018-09-14|others=Catana, Ciprian; Cervenka, Simon; Akeju, Oluwaseun; Lekander, Mats; Cohen, George; Halldin, Christer; Taylor, Norman; Kim, Minhae; Hooker, Jacob M.; Loggia, Marco L. | title = Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation | url =https://www.sciencedirect.com/science/article/pii/S0889159118302423|journal=Brain, Behavior, and Immunity|language=en|volume=75 | pages = 72-83|doi=10.1016/j.bbi.2018.09.018|issn=0889-1591|issue=|via=|pmc=PMC6541932|pmid=30223011|quote=}}</ref>

<blockquote>Our work provides the first ''in vivo'' evidence supporting a role for [[Glial cell|glial]] activation in FM pathophysiology. Given that the elevations in [<sup>11</sup>C]PBR28 signal were not also accompanied by increased [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> signal, our data suggests that [[microglia]], but not astrocytes, may be driving the TSPO elevation in these regions. Although [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> signal was not found to be increased in FM patients, larger studies are needed to further assess the role of possible astrocytic contributions in FM. Overall, our data support glial modulation as a potential therapeutic strategy for FM.<ref name=":5" /></blockquote>

<gallery widths="220px" heights="220px" class="center">
File:Fibromyalgia Glial Activation Voxelwise group differences in 11CPBR28 VT. A Fig. 1.jpg|Fig 1. Fibromyalgia Glial Activation Voxelwise group differences in [<sup>11</sup>C]PBR28 VT. A
File:Fibromyalgia Glial Activation Voxelwise group differences in 11CPBR28 SUVR A. Fig. 2.jpg‎|Fig. 2. Fibromyalgia Glial Activation Voxelwise group differences in [<sup>11</sup>C]PBR28 SUVR A
File:Fibromyalgia Glial Activation Agreement between SUVR and VT analyses A. Fig. 3.jpg|Fig. 3. Fibromyalgia Glial Activation Agreement between SUVR and VT analyses A
</gallery>

<gallery widths="220px" heights="220px" class="center">
File:Fibromyalgia Glial Cells Associations between 11CPBR28 SUVR and clinical variables. Fig. 4.jpg‎|Fig 4. Fibromyalgia Glial Cells Associations between [<sup>11</sup>C]PBR28 SUVR and clinical variables
File:Fibromyalgia Glial Cells Absence of group differences in 11C-L-deprenyl-D2 λk3. Fig. 5.jpg|Fig. 5. Fibromyalgia Glial Cells Absence of group differences in [<sup>11</sup>C]-L-deprenyl-D2 λk3
</gallery>
* 2018, [https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40746 Altered Cervical Spinal Cord Resting State Activity in Fibromyalgia]<ref>{{Cite journal | last = Martucci | first = Katherine T | last2 = Weber | first2 = Kenneth A | last3 = Mackey | first3 = Sean C | date = 2018-10-03 | title = Altered Cervical Spinal Cord Resting State Activity in Fibromyalgia| url = https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40746|journal=Arthritis & Rheumatology|language=en|doi=10.1002/art.40746|issn=2326-5191|issue=3 | pages = 441-450|pmc=|pmid=|quote=|access-date=|via=|volume=71}}</ref> (''See'': "Supporting Information" for images.)
* 2018, [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203755 Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias]<ref name=":6">{{Cite journal | last = Wolfe | first = Frederick | last2 = Walitt | first2 = Brian | last3 = Perrot | first3 = Serge | last4 = Rasker | first4 = Johannes J. | last5 = Häuser | first5 = Winfried | date = 2018-09-13 | title = Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias| url = https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203755|journal=PLOS ONE|language=en|volume=13|issue=9| pages = e0203755|doi=10.1371/journal.pone.0203755|issn=1932-6203|pmc=|pmid=30212526}}</ref>
<blockquote>What we did not find in our unbiased CritFM samples was 9:1 female to male fibromyalgia ratios that are widely described by expert sources [11–13]. We believe that such findings only occur in the presence of selection bias or biased ascertainment.<ref name=":6" /></blockquote><blockquote>As unbiased epidemiological studies show only a small increase in the female to male sex ratio (~1.5:1) as opposed to the observed ratio in clinical studies of 9:1, we believe that the over-identification of fibromyalgia in women and the consequent under-identification of men is the result of bias.<ref name=":6" /></blockquote>

* 2018, [https://www.dovepress.com/characterizing-classes-of-fibromyalgia-within-the-continuum-of-central-peer-reviewed-fulltext-article-JPR Characterizing classes of fibromyalgia within the continuum of central sensitization syndrome]<ref name=":8">{{Cite journal | last = Davis | first = Fred | authorlink = | last2 = Gostine | first2 = Mark | authorlink2 = | last3 = Roberts | first3 = Bradley | authorlink3 = | last4 = Risko | first4 = Rebecca | authorlink4 = | last5 = Cappelleri | first5 = Joseph | authorlink5 = | last6 = Sadosky | first6 = Alesia | date = 2018 | title = Characterizing classes of fibromyalgia within the continuum of central sensitization syndrome | url =https://www.dovepress.com/characterizing-classes-of-fibromyalgia-within-the-continuum-of-central-peer-reviewed-fulltext-article-JPR|journal=Journal of Pain Research|language=English|volume= 11|issue= | pages = 2551–2560|doi=10.2147/JPR.S147199|issn=1178-7090|quote=|via=}}</ref>
<blockquote>FM is a disease continuum characterized by progressive and identifiable classifications. Four classes of FM can be differentiated by pain and symptom severity, specific comorbidities, and use of clinical procedures.<ref name=":8" /></blockquote>

* 2018, [https://www.clinicaltherapeutics.com/article/S0149-2918(19)30003-7/fulltext Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences]<ref name=":9">{{Cite journal | last = Natelson | first = Benjamin H. | date = 2019-02-19 | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: Definitions, Similarities, and Differences| url = https://www.clinicaltherapeutics.com/article/S0149-2918(19)30003-7/abstract|journal=Clinical Therapeutics|language=English|volume=41|issue=4 | pages = 612|doi=10.1016/j.clinthera.2018.12.016|issn=0149-2918|pmid=30795933}}</ref>
<blockquote>This commentary presents a simplified way of making the diagnosis of [[ME/CFS|myalgic encephalomyelitis/chronic fatigue syndrome]] (ME/CFS) using the [[Fukuda criteria|1994 Centers for Disease Control and Prevention case definition]]. The format used can easily be modified for other case definitions. The commentary then discusses whether [[ME/CFS]] is the same or a different illness from fibromyalgia. Because overlap exists between the 2 syndromes, some investigators have posited that they are variants of the same illness. I have viewed this as an empirically testable hypothesis and have summoned considerable amounts of data that suggest that the 2 illnesses differ. Were differences to exist, that would suggest different pathophysiologic processes for each, leading to different treatments.<ref name=":9" /></blockquote>

*2018, [https://onlinelibrary.wiley.com/doi/abs/10.1111/jabr.12137 The neurobiology of central sensitization]<ref name="Clauw2018">{{Cite journal | last = Harte | first = Steven E. | author-link = | last2 = Harris | first2 = Richard E. | authorlink2 = | last3 = Clauw | first3 = Daniel J. | authorlink3 = Daniel Clauw | date = 2018 | title = The neurobiology of central sensitization | url =https://onlinelibrary.wiley.com/doi/abs/10.1111/jabr.12137|journal=Journal of Applied Biobehavioral Research|language=en|volume=23|issue=2| pages = e12137|doi=10.1111/jabr.12137|issn=1751-9861|pmc=|pmid=|access-date=|quote=|via=}}</ref>

*2019, [http://www.jbc.org/content/early/2018/12/06/jbc.RA118.005816 Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders]<ref name="Hackshaw2018" />
::A '''fibromyalgia blood test''' was the aim of the study by Hacksaw et al (2018), which looked for a fibromyalgia biomarker and found a unique metabolic fingerprint which distinguished all patients with fibromyalgia from those with [[systemic lupus erythematosus]], [[rheumatoid arthritis]] and [[osteoarthritis]].<ref name="Hackshaw2018">{{Cite journal | last = Rodriguez-Saona | first = Luis | author-link = | last2 = Giusti | first2 = M. Mónica | authorlink2 = | last3 = Buffington | first3 = Charles A. T. | authorlink3 = | last4 = Yu | first4 = Lianbo | authorlink4 = | last5 = Madiai | first5 = Francesca | authorlink5 = | last6 = Pujolras | first6 = Marcal Plans | authorlink6 = | last7 = Sigurdson | first7 = Gregory T. | author-link7 = | last8 = Aykas | first8 = Didem P. | author-link8 = | last9 = Hackshaw | first9 = Kevin V. | author-link9 = Kevin Hacksaw | date = Dec 6, 2018 | title = Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders| url = http://www.jbc.org/content/early/2018/12/06/jbc.RA118.005816|journal=Journal of Biological Chemistry|language=en|edition=|volume=|issue=| pages=jbc.RA118.005816|doi=10.1074/jbc.RA118.005816|issn=0021-9258|pmid=30523152|quote=|ref=Hackshaw2018|via=|pmc=|access-date=}}</ref> The study only analysed blood samples from rheumatic diseases, so it did not include patients with [[ME/CFS]] or other illnesses which can chronic pain.<ref name="Hackshaw2018" />

*2019, RETRACTED [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216079 Is insulin resistance the cause of fibromyalgia? A preliminary report]<ref name="a1cstudy">{{Cite journal | last = Pappolla | first = Miguel A. | last2 = Manchikanti | first2 = Laxmaiah | last3 = Andersen | first3 = Clark R. | last4 = Greig | first4 = Nigel H. | last5 = Ahmed | first5 = Fawad | last6 = Fang | first6 = Xiang | last7 = Seffinger | first7 = Michael A. | last8 = Trescot | first8 = Andrea M. | date = 2019-05-06 | title = Is insulin resistance the cause of fibromyalgia? A preliminary report| url = https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216079|journal=PLOS ONE|language=en|volume=14|issue=5| pages = e0216079|doi=10.1371/journal.pone.0216079|issn=1932-6203|pmc=PMC6502334|pmid=31059525}}</ref> [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216079 (Full text)]
:[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226174 Retraction notice]. :Retracted due to post-publication ethics approval and lack of gender, age and ethnic group controls in comparison group.

*2019, [https://www.sciencedirect.com/science/article/pii/S0049017218303639 A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia ethiopathogenesis]<ref name="Grayston2019">{{Cite journal | date = 2019-04-01 | title = A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia etiopathogenesis| url = https://www.sciencedirect.com/science/article/pii/S0049017218303639 | first1 = Rebecca | last1 = Grayston | first2 = Gabriela | last2 = Czanner | first3 =  Kareim | last3 = Elhadd | first4 = Andreas | last4 = Goebel | first5 = Bernhard | last5 = Frank | first6 = Nurcan | last6 = Üçeyler | first7 = Rayaz A | last7 = Malik | first8 = Uazman | last8 = Alam | journal =Seminars in Arthritis and Rheumatism|language=en|volume=48|issue=5 | pages = 933–940|doi=10.1016/j.semarthrit.2018.08.003|issn=0049-0172}}</ref>

*2019, [https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013340/abstract Mixed exercise training for adults with fibromyalgia]<ref>{{Cite journal | last = Bidonde | first = Julia | last2 = Busch | first2 = Angela J | last3 = Schachter | first3 = Candice L | last4 = Webber | first4 = Sandra C | last5 = Musselman | first5 = Kristin E | last6 = Overend | first6 = Tom J | last7 = Góes | first7 = Suelen M | last8 = Dal Bello-Haas | first8 = Vanina | last9 = Boden | first9 = Catherine | date = 2019-05-24|editor-last = Cochrane Musculoskeletal Group | title = Mixed exercise training for adults with fibromyalgia| url = https://doi.wiley.com/10.1002/14651858.CD013340|journal=Cochrane Database of Systematic Reviews|language=en|doi=10.1002/14651858.CD013340|pmc=PMC6931522|pmid=31124142}}</ref>

*2019, [https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6430597/ An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia]<ref name="Cannabis2019">{{Cite journal | last = van de Donk | first = Tine | authorlink = | last2 = Niesters | first2 = Marieke | authorlink2 = | last3 = Kowal | first3 = Mikael A. | authorlink3 = | last4 = Olofsen | first4 = Erik | authorlink4 = | last5 = Dahan | first5 = Albert | authorlink5 = | last6 = van Velzen | first6 = Monique | authorlink6 = | date = Apr 2019 | title = An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430597/|journal=Pain|volume=160|issue=4 | pages = 860–869|doi=10.1097/j.pain.0000000000001464|issn=0304-3959|pmc=6430597|pmid=30585986|access-date=|quote=|via=}}</ref>

*2019, [https://www.tandfonline.com/doi/abs/10.1080/07853890.2018.1564360 Dietary interventions in fibromyalgia: a systematic review]<ref>{{Cite journal | last = Silva | first = Ana Rita | last2 = Bernardo | first2 = Alexandra | last3 = Costa | first3 = João | last4 = Cardoso | first4 = Alexandra | last5 = Santos | first5 = Paula | last6 = de Mesquita | first6 = Maria Fernanda | last7 = Vaz Patto | first7 = José | last8 = Moreira | first8 = Pedro | last9 = Silva | first9 = Maria Leonor | date = 2019-03-29 | title = Dietary interventions in fibromyalgia: a systematic review | url =https://doi.org/10.1080/07853890.2018.1564360|journal=Annals of Medicine|volume=51|issue=sup1 | pages = 2–14|doi=10.1080/07853890.2018.1564360|issn=0785-3890|pmc=PMC7888848|pmid=30735059}}</ref>

*2019, [https://pubmed.ncbi.nlm.nih.gov/31151332/ Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis]<ref>{{Cite journal | last = Yeh | first = Shu-Wei | last2 = Hong | first2 = Chien-Hsiung | last3 = Shih | first3 = Ming-Chieh | last4 = Tam | first4 = Ka-Wai | last5 = Huang | first5 = Yao-Hsien | last6 = Kuan | first6 = Yi-Chun | date = May 2019 | title = Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis| url = https://pubmed.ncbi.nlm.nih.gov/31151332/|journal=Pain Physician|volume=22|issue=3 | pages = 241–254|issn=2150-1149|pmid=31151332|doi=|pmc=|quote=|access-date=|via=}}</ref>

*2019, [https://www.jpain.org/article/S1526-5900(18)30832-0/fulltext AAPT Diagnostic Criteria for Fibromyalgia]<ref name="AAPT2019">{{Cite journal | last = Arnold | first = Lesley M. | author-link = | last2 = Bennett | first2 = Robert M. | authorlink2 = | last3 = Crofford | first3 = Leslie J. | authorlink3 = | last4 = Dean | first4 = Linda E. | authorlink4 = | last5 = Clauw | first5 = Daniel J. | authorlink5 = Daniel Clauw | last6 = Goldenberg | first6 = Don L. | authorlink6 = | last7 = Fitzcharles | first7 = Mary-Ann | last8 = Paiva | first8 = Eduardo S. | last9 = Staud | first9 = Roland | date = 2019-06-01 | title = AAPT Diagnostic Criteria for Fibromyalgia| url = https://www.jpain.org/article/S1526-5900(18)30832-0/abstract|journal=The Journal of Pain|language=English|volume=20|issue=6 | pages = 611–628|doi=10.1016/j.jpain.2018.10.008|issn=1526-5900|pmc=|pmid=30453109|access-date=|quote=|via=}}</ref>

===2020-2024===
*2020, [https://doi.org/10.1186/s12891-020-03201-9 Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review] <ref>{{Cite journal|title=Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review|date=2020-03-20|url=https://doi.org/10.1186/s12891-020-03201-9|journal=BMC Musculoskeletal Disorders|volume=21|issue=1|pages=181|last=Erdrich|first=Sharon|last2=Hawrelak|first2=Jason A.|last3=Myers|first3=Stephen P.|last4=Harnett|first4=Joanna E.|doi=10.1186/s12891-020-03201-9|pmc=PMC7083062|pmid=32192466|issn=1471-2474}}</ref>
*2020, [https://doi.org/10.1177/1756284820977402 A systematic review of the association between fibromyalgia and functional gastrointestinal disorders]<ref>{{Cite web|url=https://doi.org/10.1177/1756284820977402|title=https://journals.sagepub.com/doi/10.1177/1756284820977402}}</ref>
*2020, [https://irispublishers.com/arar/fulltext/Investigating-Fatigue-and-Exercise-Intolerance-in-a-University.ID.000505.php Investigating Fatigue and Exercise Intolerance in a University Immunology Clinic]<ref name="Ambrus2020">{{Cite journal | last = Ambrus | first = Julian L. | last2 = Isackson | first2 = Paul | last3 = Moore | first3 = Molly | last4 = Butsch | first4 = John | last5 = Balos | first5 = Lucia | date = 2020-02-18 | title = Investigating Fatigue and Exercise Intolerance in a University Immunology Clinic| url = https://irispublishers.com/arar/fulltext/Investigating-Fatigue-and-Exercise-Intolerance-in-a-University.ID.000505.php|journal=Archives of Rheumatology & Arthritis Research|language=English|volume=1|issue=1 | pages = 1–8}}</ref>

*2020, [https://www.sciencedirect.com/science/article/pii/S0049017221000275 Fibromyalgia and obesity: A comprehensive systematic review and meta-analysis]<ref name="DOnghia2020">{{Cite journal | last = D'Onghia | first = Martina | last2 = Ciaffi | first2 = Jacopo | last3 = Lisi | first3 = Lucia | last4 = Mancarella | first4 = Luana | last5 = Ricci | first5 = Susanna | last6 = Stefanelli | first6 = Nicola | last7 = Meliconi | first7 = Riccardo | last8 = Ursini | first8 = Francesco | date = 2021-04-01 | title = Fibromyalgia and obesity: A comprehensive systematic review and meta-analysis| url = https://www.sciencedirect.com/science/article/pii/S0049017221000275|journal=Seminars in Arthritis and Rheumatism|language=en|volume=51|issue=2 | pages = 409–424|doi=10.1016/j.semarthrit.2021.02.007|issn=0049-0172}}</ref>

*2020, [https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1585 Comorbidities of self-reported fibromyalgia in United States adults: A cross-sectional study from The National Epidemiological Survey on Alcohol and Related Conditions (NESARC-III)]<ref name="Sleurs2020">{{Cite journal | last = Sleurs | first = David | authorlink = | last2 = Tebeka | first2 = Sarah | authorlink2 = | last3 = Scognamiglio | first3 = Claire | authorlink3 = | last4 = Dubertret | first4 = Caroline | authorlink4 = | last5 = Le Strat | first5 = Yann | authorlink5 = | date = 2020 | title=Comorbidities of self-reported fibromyalgia in United States adults: A cross-sectional study from The National Epidemiological Survey on Alcohol and Related Conditions (NESARC-III)| url = https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1585|journal=European Journal of Pain|language=en|volume=24|issue=8 | pages = 1471–1483|doi=10.1002/ejp.1585|issn=1532-2149|pmc=|pmid=|access-date=|quote=|via=}}</ref>

*2020, [https://pubmed.ncbi.nlm.nih.gov/31982685/ Is Transcranial Direct Current Stimulation (tDCS) Effective for the Treatment of Pain in Fibromyalgia? A Systematic Review and Meta-Analysis]<ref>{{Cite journal | last = Lloyd | first = Donna M. | author-link = | last2 = Wittkopf | first2 = Priscilla G. | authorlink2 = | last3 = Arendsen | first3 = Laura J. | authorlink3 = | last4 = Jones | first4 = Anthony K. P. | authorlink4 = | date = Nov 2020 | title = Is Transcranial Direct Current Stimulation (tDCS) Effective for the Treatment of Pain in Fibromyalgia? A Systematic Review and Meta-Analysis| url = https://pubmed.ncbi.nlm.nih.gov/31982685/|journal=The Journal of Pain|volume=21|issue=11-12 | pages = 1085–1100|doi=10.1016/j.jpain.2020.01.003|issn=1528-8447|pmc=|pmid=31982685|access-date=|quote=|via=}}</ref>

*2020, [https://pubmed.ncbi.nlm.nih.gov/33071017/ Effects of transcranial direct current stimulation and transcranial magnetic stimulation in patients with fibromyalgia. A systematic review]<ref>{{Cite journal | last = Conde-Antón | first = Á | last2 = Hernando-Garijo | first2 = I. | last3 = Jiménez-Del-Barrio | first3 = S. | last4 = Mingo-Gómez | first4 = M.T. | last5 = Medrano-de-la-Fuente | first5 = R. | last6 = Ceballos-Laita | first6 = L. | date = 2020-10-15 | title = Effects of transcranial direct current stimulation and transcranial magnetic stimulation in patients with fibromyalgia. A systematic review | url =https://pubmed.ncbi.nlm.nih.gov/33071017/|journal=Neurologia (Barcelona, Spain)| pages=S0213–4853(20)30278–4|doi=10.1016/j.nrl.2020.07.024|issn=2173-5808|pmid=33071017}}</ref>
{{See also|Transcranial direct current stimulation |Transcranial direct current stimulation|Transcranial magnetic stimulation|Transcranial magnetic stimulation}}

*2021, [https://doi.org/10.1080/02713683.2021.1951301 Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life]<ref name="Cordon2021">{{Cite journal | last = Cordón | first = B. | last2 = Orduna | first2 = E. | last3 = Viladés | first3 = E. | last4 = Garcia-Martin | first4 = E. | last5 = Garcia-Campayo | first5 = J. | last6 = Puebla-Guedea | first6 = M. | last7 = Polo | first7 = V. | last8 = Larrosa | first8 = J.M. | last9 = Pablo | first9 = L.E. | date = 2021-07-02 | title = Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life | url =https://doi.org/10.1080/02713683.2021.1951301|journal=Current Eye Research|volume=0|issue=0 | pages = 1–11|doi=10.1080/02713683.2021.1951301|issn=0271-3683|pmid=34213409}}</ref>
::A potential biomarker for fibromyalgia, using a non-invasive eye test.

*2021, [https://www.mdpi.com/2075-4418/11/2/156/htm The Search for Biomarkers in Fibromyalgia]<ref name="Hackshaw2021">{{Cite journal | last = Hackshaw | first = Kevin V. | author-link = Kevin Hackshaw | date = Feb 2021 | title = The Search for Biomarkers in Fibromyalgia| url = https://www.mdpi.com/2075-4418/11/2/156/htm|journal=Diagnostics|language=en|volume=11|issue=2 | pages = 156|doi=10.3390/diagnostics11020156|pmc=PMC7911687|pmid=33494476|access-date=|quote=|via=}}</ref>
*2021, [https://www.painphysicianjournal.com/linkout?issn&vol=24&page=175 Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia Observational Study]<ref name="Fang2021">{{Cite journal | title = Insulin Resistance is Associated with Central Pain in Patients with Fibromyalgia | date = Mar 2021| url = https://www.painphysicianjournal.com/linkout?issn&vol=24&page=175|journal=Pain Physician|volume=24|issue=2 | pages = 175–184 | last = Pappolla | first = Miguel A. | author-link = | last2 = Manchikanti | first2 = Laxmaiah | authorlink2 = | last3 = Candido | first3 = KennethD. | authorlink3 = | last4 = Grieg | first4 = Nigel | authorlink4 = | last5 = Seffinger | first5 = Michael | authorlink5 = | last6 = Ahmed | first6 = Fauwad | authorlink6 = | last7 = Fang | first7 = Xiang | last8 = Andersen | first8 = Clark | last9 = Trescot | first9 = Andrea M.|doi=|pmc=|pmid=33740353|access-date=|issn=2150-1149|quote=|via=}}</ref> - authors in common with the retracted 2019 insulin resistance study
===Depression and anxiety ===
*2008, The relationship between fibromyalgia and major depressive disorder: a comprehensive review<ref name="Pae2008">{{Cite journal | last = Pae | first = Chi-Un | author-link = | last2 = Luyten | first2 = Patrick | authorlink2 = | last3 = Marks | first3 = David M. | authorlink3 = | last4 = Han | first4 = Changsu | authorlink4 = | last5 = Park | first5 = Sung-Hwan | authorlink5 = | last6 = Patkar | first6 = Ashwin A. | authorlink6 = | last7 = Masand | first7 = Prakash S. | last8 = Houdenhove | first8 = Boudewijn Van | author-link8 = Boudewijn Van Houdenhove | date = 2008-08-01 | title = The relationship between fibromyalgia and major depressive disorder: a comprehensive review | url =https://doi.org/10.1185/03007990802288338|journal=Current Medical Research and Opinion|volume=24|issue=8 | pages = 2359–2371|doi=10.1185/03007990802288338|issn=0300-7995|pmc=|pmid=18606054|access-date=|quote=|via=}}</ref> [https://doi.org/10.1185/03007990802288338 (Abstract)]
*2010, Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain<ref name="Jensen2010">{{Cite journal | last = Jensen | first = Karin B. | last2 = Petzke | first2 = Frank | last3 = Carville | first3 = Serena | last4 = Fransson | first4 = Peter | last5 = Marcus | first5 = Hanke | last6 = Williams | first6 = Steven C.R. | last7 = Choy | first7 = Ernest | last8 = Mainguy | first8 = Yves | last9 = Gracely | first9 = Richard | date = 2010 | title=Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain | url =https://onlinelibrary.wiley.com/doi/abs/10.1002/art.27649|journal=Arthritis & Rheumatism|language=en|volume=62|issue=11 | pages = 3488–3495|doi=10.1002/art.27649|issn=1529-0131}}</ref> [https://doi.org/10.1002/art.27649 (Abstract)]
*2012, Fibromyalgia a discrete entity?<ref name="Ablin2012">{{cite journal | last = Ablin | first = Jacob N. | last2 = Buskila | first2 = Dan | last3 = Van Houdenhove | first3 = Boudewijn | last4 = Luyten | first4 = Patrick | last5 = Atzeni | first5 = Fabiola | last6 = Sarzi-Puttini | first6 = Piercarlo  | title = Is fibromyalgia a discrete entity? |journal=Autoimmunity Reviews | url = https://doi.org/10.1016%2Fj.autrev.2011.10.018 | volume=11 | issue=8 | pages = 585–588 | date =Jun 2012 | issn=1568-9972 | doi=10.1016/j.autrev.2011.10.018 }}</ref> [https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.27649 (Full text)]

=== Psychological paradigm ===
*2012, Personality and Fibromyalgia Syndrome<ref name="Malin2012">{{Cite journal | last = Malin | first = Katrina | last2 = Littlejohn | first2 = Geoffrey O | date = 2012-09-07 | title = Personality and Fibromyalgia Syndrome | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447191/|journal=The Open Rheumatology Journal|volume=6 | pages = 273–285|doi=10.2174/1874312901206010273|issn=1874-3129|pmid=23002409|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447191/ (Full text)]

:<blockquote>Conclusion: No specific fibromyalgia personality is defined but it is proposed that personality is an important filter that modulates a person’s response to psychological stressors. Certain personalities may facilitate translation of these stressors to physiological responses driving the fibromyalgia mechanism.<ref name="Malin2012" /></blockquote>

*2015, Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.<ref name="Theoharides215">{{Cite journal | last = Theoharides | first = Theoharis C. | last2 = Stewart | first2 = Julia M. | last3 = Hatziagelaki | first3 = Erifili | last4 = Kolaitis | first4 = Gerasimos | date = 2015 | title=Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin | url =https://www.ncbi.nlm.nih.gov/pubmed/26190965|journal=Frontiers in Neuroscience|volume=9 | pages = 225|doi=10.3389/fnins.2015.00225|issn=1662-4548|pmid=26190965|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/26190965 (Full text)]

*2015, Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome<ref>{{Cite journal | last = Efrati | first = Shai | last2 = Golan | first2 = Haim | last3 = Bechor | first3 = Yair | last4 = Faran | first4 = Yifat | last5 = Daphna-Tekoah | first5 = Shir | last6 = Sekler | first6 = Gal | last7 = Fishlev | first7 = Gregori | last8 = Ablin | first8 = Jacob N. | last9 = Bergan | first9 = Jacob | first10 = Olga | last10 = Volkov | first11 = Mony | last11 = Friedman | first12 = Eshel | last12 = Ben-Jacob | first13 = Dan | last13 = Buskila | date = 2015-05-26 | title = Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome – Prospective Clinical Trial| url = http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012|journal=PLOS ONE|language=en|volume=10|issue=5| pages = e0127012|doi=10.1371/journal.pone.0127012|issn=1932-6203|pmid=26010952|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pubmed/26190965 (Full text)]
{{See also|Hyperbaric oxygen therapy}}

*2016, Explaining unexplained pain to fibromyalgia patients: finding a narrative that is acceptable to patients and provides a rationale for evidence-based interventions<ref name="Hyland2016">{{Cite journal | last = Hyland | first = Michael E | last2 = Hinton | first2 = Claire | last3 = Hill | first3 = Charlotte | last4 = Whalley | first4 = Ben | last5 = Jones | first5 = Rupert CM | last6 = Davies | first6 = Anthony F | date = 2016-07-08 | title = Explaining unexplained pain to fibromyalgia patients: finding a narrative that is acceptable to patients and provides a rationale for evidence based interventions| url = http://journals.sagepub.com/doi/pdf/10.1177/2049463716642601|journal=British Journal of Pain|language=en|volume=10|issue=3 | pages = 156–161|doi=10.1177/2049463716642601|issn=2049-4637|pmid=27583142|via=}}</ref> [http://bjp.sagepub.com/content/10/3/156.full.pdf+html (Full text)]

* 2016, Fibromyalgia: A Short Commentary<ref name="Wolfe2016Comm">{{Cite journal | last = Wolfe | first = Frederick | author-link = Frederick Wolfe | authorlink2 = Brian Walitt | last2 = Walitt | first2 = Brian | date = Oct 15, 2016 | title = Fibromyalgia: A Short Commentary| url = https://www.researchgate.net/profile/Fred-Wolfe/publication/310835395_Fibromyalgia_A_Short_Commentary/links/5846959108aeda69681f81bd/Fibromyalgia-A-Short-Commentary.pdf | format=|journal=Journal of Headache & Pain Management|volume=1|issue=3 | pages = 27|doi=10.4172/2472-1913.100027|issn=2472-1913|pmc=|pmid=|quote=|access-date=}}</ref> [https://www.researchgate.net/profile/Fred-Wolfe/publication/310835395_Fibromyalgia_A_Short_Commentary/links/5846959108aeda69681f81bd/Fibromyalgia-A-Short-Commentary.pdf (Full text)]

===Grant awards and current research===
*Oct 2016, [http://www.uofmhealth.org/news/archive/201610/chronic-pain-researchers-expand-work-75m-award-nih Chronic pain researchers to expand work with $7.5M award from NIH]<ref>{{Cite web | url=https://www.uofmhealth.org/news/archive/201610/chronic-pain-researchers-expand-work-75m-award-nih | title = Chronic pain researchers to expand work with $7.5M award from NIH {{!}} Michigan Medicine | last = | first = | date = Oct 17, 2016 | website = uofmhealth.org|language=en|archive-url=|archive-date=|access-date=2018-08-09}}</ref>
*Jun 2018, The [[Bateman Horne Center]] will be an ''[https://allofus.nih.gov All of Us]'' recruitment center for people living with [[ME/CFS]] and fibromyalgia. ''All of Us'' is a ten year Precision Medicine Initiative project that has been funded $1.5 Billion to recruit one million patients for its bio-bank. The idea is to research all diseases, from the most common to the most rare while taking into account lifestyle, environment, and biology.<ref>{{Cite news | url=http://batemanhornecenter.org/nih-announces-precision-medicine-initiative/ | title = NIH Announces Precision Medicine Initiative - Bateman Horne Center | last = Black | first = Rachel | date = 2018-06-20|work=Bateman Horne Center|access-date=2018-08-09|archive-url=|archive-date=|language=en-US}}</ref><ref>{{Cite web | url=https://allofus.nih.gov | title = National Institutes of Health (NIH) — All of Us|website=allofus.nih.gov|language=en|access-date=2018-08-09}}</ref>

== See also ==
* [[Fibromyalgia]]
* [[Fibromyalgia disability process]]
* [[Fibromyalgia drugs]]


== References ==
{{Reflist}}
[[Category:Notable studies]]