Editing Fibromyalgia notable studies
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*2011, [https://doi.org/10.1186/1477-7525-9-71 The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States]<ref name="Schaefer2011">{{Cite journal | last = Schaefer | first = Caroline | last2 = Chandran | first2 = Arthi | last3 = Hufstader | first3 = Meghan | last4 = Baik | first4 = Rebecca | last5 = McNett | first5 = Michael | last6 = Goldenberg | first6 = Don | last7 = Gerwin | first7 = Robert | last8 = Zlateva | first8 = Gergana | date = 2011-08-22 | title = The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States| url = https://doi.org/10.1186/1477-7525-9-71|journal=Health and Quality of Life Outcomes|volume=9|issue=1 | pages = 71|doi=10.1186/1477-7525-9-71|issn=1477-7525|pmc=3179696|pmid=21859448}}</ref> | *2011, [https://doi.org/10.1186/1477-7525-9-71 The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States]<ref name="Schaefer2011">{{Cite journal | last = Schaefer | first = Caroline | last2 = Chandran | first2 = Arthi | last3 = Hufstader | first3 = Meghan | last4 = Baik | first4 = Rebecca | last5 = McNett | first5 = Michael | last6 = Goldenberg | first6 = Don | last7 = Gerwin | first7 = Robert | last8 = Zlateva | first8 = Gergana | date = 2011-08-22 | title = The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States| url = https://doi.org/10.1186/1477-7525-9-71|journal=Health and Quality of Life Outcomes|volume=9|issue=1 | pages = 71|doi=10.1186/1477-7525-9-71|issn=1477-7525|pmc=3179696|pmid=21859448}}</ref> | ||
*2012, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394355/ Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management]<ref name="Jahan2012">{{Cite journal | last = Jahan | first = Firdous | last2 = Nanji | first2 = Kashmira | last3 = Qidwai | first3 = Waris | last4 = Qasim | first4 = Rizwan | date = 2012 | title = Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394355/|journal=Oman Medical Journal|volume=27|issue=3 | pages = 192–195|doi=10.5001/omj.2012.44|issn=1999-768X|pmc=|pmid=22811766|via=}}</ref> | *2012, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394355/ Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management]<ref name="Jahan2012">{{Cite journal | last = Jahan | first = Firdous | last2 = Nanji | first2 = Kashmira | last3 = Qidwai | first3 = Waris | last4 = Qasim | first4 = Rizwan| date = 2012 | title = Fibromyalgia Syndrome: An Overview of Pathophysiology, Diagnosis and Management| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394355/|journal=Oman Medical Journal|volume=27|issue=3 | pages = 192–195|doi=10.5001/omj.2012.44|issn=1999-768X|pmc=|pmid=22811766|via=}}</ref> | ||
<blockquote>Pathophysiology: Although the etiology remains unclear, characteristic alterations in the [[Sleep dysfunction|pattern of sleep]] and changes in neuroendocrine transmitters such as [[serotonin]], [[substance P]], growth hormone and [[cortisol]] suggest that regulation of the [[Autonomic nervous system|autonomic]] and neuro-endocrine system appears to be the basis of the syndrome. Fibromyalgia is not a life-threatening, deforming, or progressive disease. [[Anxiety]] and [[depression]] are the most common association. Aberrant pain processing, which can result in [[chronic pain]], may be the result of several interplaying mechanisms. [[Central sensitization]], blunting of inhibitory pain pathways and alterations in [[neurotransmitter]]s lead to aberrant neuro-chemical processing of sensory signals in the [[central nervous system|CNS]], thus lowering the threshold of pain and amplification of normal sensory signals causing constant pain.<ref name="Jahan2012" /></blockquote><blockquote>The frequent co-morbidity of fibromyalgia with mood disorders suggests a major role for the stress response and for [[neuroendocrine system|neuroendocrine]] abnormalities. The [[hypothalamic pituitary axis]] (HPA) is a critical component of the stress-adaptation response. In FMS, stress adaptation response is disturbed leading to stress induce symptoms. Psychiatric co-morbidity has been associated with FMS and needs to be identified during the consultation process, as this requires special consideration during treatment.<ref name="Jahan2012" /></blockquote> | <blockquote>Pathophysiology: Although the etiology remains unclear, characteristic alterations in the [[Sleep dysfunction|pattern of sleep]] and changes in neuroendocrine transmitters such as [[serotonin]], [[substance P]], growth hormone and [[cortisol]] suggest that regulation of the [[Autonomic nervous system|autonomic]] and neuro-endocrine system appears to be the basis of the syndrome. Fibromyalgia is not a life-threatening, deforming, or progressive disease. [[Anxiety]] and [[depression]] are the most common association. Aberrant pain processing, which can result in [[chronic pain]], may be the result of several interplaying mechanisms. [[Central sensitization]], blunting of inhibitory pain pathways and alterations in [[neurotransmitter]]s lead to aberrant neuro-chemical processing of sensory signals in the [[central nervous system|CNS]], thus lowering the threshold of pain and amplification of normal sensory signals causing constant pain.<ref name="Jahan2012" /></blockquote><blockquote>The frequent co-morbidity of fibromyalgia with mood disorders suggests a major role for the stress response and for [[neuroendocrine system|neuroendocrine]] abnormalities. The [[hypothalamic pituitary axis]] (HPA) is a critical component of the stress-adaptation response. In FMS, stress adaptation response is disturbed leading to stress induce symptoms. Psychiatric co-morbidity has been associated with FMS and needs to be identified during the consultation process, as this requires special consideration during treatment.<ref name="Jahan2012" /></blockquote> | ||