Talk:Collagen

Rheumatological presentation of Bartonella koehlerae and Bartonella henselae bacteremias: A case report https://journals.lww.com/md-journal/Pages/articleviewer.aspx?year=2018&issue=04270&article=00032&type=Fulltext

Cross reaction of antibodies to a glycine/alanine repeat sequence of Epstein-Barr virus nuclear antigen-1 with collagen, cytokeratin, and actin. https://ard.bmj.com/content/annrheumdis/50/11/772.full.pdf

Herpes-simplex virus encephalitis is characterized by an early MMP-9 increase and collagen type IV degradation https://www.sciencedirect.com/science/article/pii/S0006899306029246

Potential treatment table

I think there need to be more references for the potential treatment table. Just because a substance is involved somewhere in the production or degradation of Collagen, doesn't mean that taking more of it, is a 'potential treatment'. Perhaps the best way to proceed is just to change the title from potential treatment to substances involved in collagen metabolism or something like that. Hip JenB

Agreed, I think perhaps the best way would be to separate the compounds which have an evidence base for helping connective tissue conditions, from compounds which theoretically might help but there's no evidence. In the case of low-dose doxycycline, this is sold as drug called Periostat for treating receding gums (periodontitis), which is due to elevated levels of connective tissue-degrading enzymes called MMPs. So the evidence is strong. Periostat is the only FDA licensed MMP inhibitor drug.

For fish oil and Q10, in vivo studies on MS patients found these reduce MMP-9. So that's reasonable evidence. Ecklonia cava inhibits MMP-2 and MMP-9 and reduced periodontitis in a rat study.

Supplements like magnesium, glucosamine sulfate, triphala inhibit MMPs, but this has only been shown in vitro, which means their in vivo efficacy is unknown.

I recently posted a thread on Phoenix Rising detailing these MMP inhibitors. And further info is found in this post.

BPC-157 and TB_500 have been shown to promote connective tissue repair.

Hip (talk) 11:33, September 14, 2019 (EDT)

I changed the “Potential treatments” heading to “Potential modulators”, I hope that’s okay with everyone. Since collagen is not a disease or condition, it seems a bit silly to talk about “treatments”.

Pyrrhus (talk) 14:10, September 14, 2019 (EDT)