Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Regulatory T cell
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== Chronic Fatigue Syndrome and ME/CFS == An [[Australia|Australian]] group found that Tregs were elevated in thirty individuals with [[Fukuda criteria|Fukuda]] for [[chronic fatigue syndrome]] (CFS).<ref>{{Cite journal | last = Brenu | first = Ekua Weba | last2 = Huth | first2 = Teilah K. | last3 = Hardcastle | first3 = Sharni L. | last4 = Fuller | first4 = Kirsty | last5 = Kaur | first5 = Manprit | last6 = Johnston | first6 = Samantha | last7 = Ramos | first7 = Sandra B. | last8 = Staines | first8 = Don R. | last9 = Marshall-Gradisnik | first9 = Sonya M. | date = Apr 2014 | title = Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis|url=https://www.ncbi.nlm.nih.gov/pubmed/24343819|journal=International Immunology|volume=26|issue=4|pages=233–242|doi=10.1093/intimm/dxt068|issn=1460-2377|pmid=24343819}}</ref> The same group found elevated Tregs in a multiple sclerosis comparison study.<ref name="Ramos, 2016" /> However, a study that used the [[Revised Canadian Consensus Criteria]] (2010) criteria found Tregs were depleted in 76 people with [[ME/CFS]].<ref name=":0">{{Cite journal | last = Rivas | first = Jose Luis | last2 = Palencia | first2 = Teresa | last3 = Fernández | first3 = Guerau | last4 = García | first4 = Milagros| date = 2018-05-09 | title = Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954087/|journal=Frontiers in Immunology|volume=9|doi=10.3389/fimmu.2018.01028|issn=1664-3224|pmc=5954087|pmid=29867995}}</ref> A second study in Japan also found decreased Tregs in 41 people who met both the [[Canadian Consensus Criteria]] and the [[International Consensus Criteria]] as compared to age- and gender-matched healthy controls.<ref>{{Cite journal | last = Yamamura | first=T. | last2 = Sato | first2 = W. | last3 = Ono | first3 = H. | date = 2017-10-15 | title = Dysregulation of T and B cells in myalgic encephalomyelitis/chronic fatigue syndrome|url=https://www.jns-journal.com/article/S0022-510X(17)33030-7/abstract|journal=Journal of the Neurological Sciences|language=English|volume=381 | pages = 899–900|doi=10.1016/j.jns.2017.08.2533|issn=0022-510X}}</ref> It is worth noting that such seemingly contradictory results are often found in the systemic autoimmune diseases in which [[T cell]] subsets are often studied. Even in illnesses with well-established [[Diagnostic biomarker|biomarkers]], age, gender, and time since onset lead to significant variability.<ref>{{Cite journal | last = Kasper | first=Isaac R. | last2 = Apostolidis | first2 = Sokratis A. | last3 = Sharabi | first3 = Amir | last4 = Tsokos | first4 = George C. | date = Sep 2016 | title = Empowering Regulatory T Cells in Autoimmunity|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003773/|journal=Trends in molecular medicine|volume=22|issue=9 | pages = 784–797|doi=10.1016/j.molmed.2016.07.003|issn=1471-4914|pmc=5003773|pmid=27461103|quote=|via=}}</ref>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs